Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation

Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the v...

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Published inHuman brain mapping Vol. 30; no. 4; pp. 1120 - 1132
Main Authors Ances, Beau M., Liang, Christine L., Leontiev, Oleg, Perthen, Joanna E., Fleisher, Adam S., Lansing, Amy E., Buxton, Richard B.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2009
Wiley-Liss
Subjects
Adult
aging
Aging - physiology
Biological and medical sciences
blood oxygen level dependent (BOLD) effect
Brain Mapping
Cardiovascular system
cerebral blood flow (CBF)
cerebral metabolic rate of oxygen (CMRO2)
Cerebrovascular Circulation - physiology
Female
functional magnetic resonance imaging (fMRI)
Humans
Hypercapnia - metabolism
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Nervous system
Nonlinear Dynamics
Oxygen - blood
Oxygen Consumption - physiology
Photic Stimulation - methods
Radiodiagnosis. Nmr imagery. Nmr spectrometry
visual cortex
Visual Cortex - blood supply
Visual Cortex - physiology
Young Adult
cerebral blood flow (CBF)
Visual cortex
Oxygen
Nervous system diseases
Senescence
Radiodiagnosis
Central nervous system
and cerebral metabolic rate of oxygen (CMRO2)
functional magnetic resonance imaging (fMRI)
Metabolism
Nuclear magnetic resonance imaging
Blood flow
Encephalon
blood oxygen level dependent (BOLD) effect
Visual pathway
Hemodynamics
aging
Oxygenation
Functional imaging
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Abstract Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO2) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28‐years‐old) and older (n = 10, mean: 53‐years‐old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO2) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO2. For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 ± 0.07%) compared to the younger group (0.95 ± 0.14%), despite the finding that the fractional CBF and CMRO2 changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 ± 0.4%) than younger subjects (6.5 ± 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 ± 4.8 mL/100 mL/min) compared to younger (59.6 ± 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post‐stimulus undershoot with no significant difference in this magnitude. However, the post‐undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
AbstractList Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO2) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28-years-old) and older (n = 10, mean: 53-years-old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO2) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO2. For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 ± 0.07%) compared to the younger group (0.95 ± 0.14%), despite the finding that the fractional CBF and CMRO2 changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 ± 0.4%) than younger subjects (6.5 ± 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 ± 4.8 mL/100 mL/min) compared to younger (59.6 ± 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post-stimulus undershoot with no significant difference in this magnitude. However, the post-undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone. Hum Brain Mapp 2009.
Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO(2)) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28-years-old) and older (n = 10, mean: 53-years-old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO(2)) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO(2). For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 +/- 0.07%) compared to the younger group (0.95 +/- 0.14%), despite the finding that the fractional CBF and CMRO(2) changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 +/- 0.4%) than younger subjects (6.5 +/- 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 +/- 4.8 mL/100 mL/min) compared to younger (59.6 +/- 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post-stimulus undershoot with no significant difference in this magnitude. However, the post-undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone.Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO(2)) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28-years-old) and older (n = 10, mean: 53-years-old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO(2)) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO(2). For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 +/- 0.07%) compared to the younger group (0.95 +/- 0.14%), despite the finding that the fractional CBF and CMRO(2) changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 +/- 0.4%) than younger subjects (6.5 +/- 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 +/- 4.8 mL/100 mL/min) compared to younger (59.6 +/- 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post-stimulus undershoot with no significant difference in this magnitude. However, the post-undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone.
Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO 2 ) and a simple checkerboard stimulus in healthy younger ( n = 10, mean: 28‐years‐old) and older ( n = 10, mean: 53‐years‐old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M , the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO 2 ) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO 2 . For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 ± 0.07%) compared to the younger group (0.95 ± 0.14%), despite the finding that the fractional CBF and CMRO 2 changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M , which was significantly lower for older (4.6 ± 0.4%) than younger subjects (6.5 ± 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 ± 4.8 mL/100 mL/min) compared to younger (59.6 ± 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post‐stimulus undershoot with no significant difference in this magnitude. However, the post‐undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO2) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28‐years‐old) and older (n = 10, mean: 53‐years‐old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO2) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO2. For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 ± 0.07%) compared to the younger group (0.95 ± 0.14%), despite the finding that the fractional CBF and CMRO2 changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 ± 0.4%) than younger subjects (6.5 ± 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 ± 4.8 mL/100 mL/min) compared to younger (59.6 ± 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post‐stimulus undershoot with no significant difference in this magnitude. However, the post‐undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc.
Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging. We simultaneously measured both the magnitude of the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) responses in the visual cortex for separate conditions of mild hypercapnia (5% CO(2)) and a simple checkerboard stimulus in healthy younger (n = 10, mean: 28-years-old) and older (n = 10, mean: 53-years-old) adults. From these data we derived baseline CBF, the BOLD scaling parameter M, the fractional change in the cerebral metabolic rate of oxygen consumption (CMRO(2)) with activation, and the coupling ratio n of the fractional changes in CBF and CMRO(2). For the functional activation paradigm, the magnitude of the BOLD response was significantly lower for the older group (0.57 +/- 0.07%) compared to the younger group (0.95 +/- 0.14%), despite the finding that the fractional CBF and CMRO(2) changes were similar for both groups. The weaker BOLD response for the older group was due to a reduction in the parameter M, which was significantly lower for older (4.6 +/- 0.4%) than younger subjects (6.5 +/- 0.8%), most likely reflecting a reduction in baseline CBF for older (41.7 +/- 4.8 mL/100 mL/min) compared to younger (59.6 +/- 9.1 mL/100 mL/min) subjects. In addition to these primary responses, for both groups the BOLD response exhibited a post-stimulus undershoot with no significant difference in this magnitude. However, the post-undershoot period of the CBF response was significantly greater for older compared to younger subjects. We conclude that when comparing two populations, the BOLD response can provide misleading reflections of underlying physiological changes. A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone.
Author Ances, Beau M.
Leontiev, Oleg
Lansing, Amy E.
Perthen, Joanna E.
Buxton, Richard B.
Fleisher, Adam S.
Liang, Christine L.
AuthorAffiliation 1 Department of Neurosciences, University of California, San Diego, California
3 Department of Psychiatry, University of California, San Diego, California
2 Department of Radiology, University of California, San Diego, California
AuthorAffiliation_xml – name: 3 Department of Psychiatry, University of California, San Diego, California
– name: 2 Department of Radiology, University of California, San Diego, California
– name: 1 Department of Neurosciences, University of California, San Diego, California
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  surname: Ances
  fullname: Ances, Beau M.
  organization: Department of Neurosciences, University of California, San Diego, California
– sequence: 2
  givenname: Christine L.
  surname: Liang
  fullname: Liang, Christine L.
  organization: Department of Radiology, University of California, San Diego, California
– sequence: 3
  givenname: Oleg
  surname: Leontiev
  fullname: Leontiev, Oleg
  organization: Department of Radiology, University of California, San Diego, California
– sequence: 4
  givenname: Joanna E.
  surname: Perthen
  fullname: Perthen, Joanna E.
  organization: Department of Radiology, University of California, San Diego, California
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  givenname: Adam S.
  surname: Fleisher
  fullname: Fleisher, Adam S.
  organization: Department of Neurosciences, University of California, San Diego, California
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  givenname: Amy E.
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– sequence: 7
  givenname: Richard B.
  surname: Buxton
  fullname: Buxton, Richard B.
  email: rbuxton@ucsd.edu
  organization: Department of Radiology, University of California, San Diego, California
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21261542$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18465743$$D View this record in MEDLINE/PubMed
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Issue 4
Keywords cerebral blood flow (CBF)
Visual cortex
Oxygen
Nervous system diseases
Senescence
Radiodiagnosis
Central nervous system
and cerebral metabolic rate of oxygen (CMRO2)
functional magnetic resonance imaging (fMRI)
Metabolism
Nuclear magnetic resonance imaging
Blood flow
Encephalon
blood oxygen level dependent (BOLD) effect
Visual pathway
Hemodynamics
aging
Oxygenation
Functional imaging
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
CC BY 4.0
2008 Wiley-Liss, Inc.
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UCSD General Clinical Research Center - No. MO1 RR000827
NIH - No. 1K23MH081786; No. NS-36722; No. NS-42069
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Dana Brain-Immuno Imaging
American Federation of AIDS Research Fellowship - No. 106729-40-RFRL
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PMID 18465743
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PublicationTitle Human brain mapping
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2002; 16
2004; 21
2004; 22
2002; 58
2006; 31
1991; 14
1995; 36
1991; 11
2006; 33
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2005; 27
2001; 308
1979; 32
2007; 35
1953; 32
1974; 5
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2005; 25
2007; 28
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2000; 31
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1997; 38
1995b; 34
1990; 113
2005; 12
2000; 181
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Snippet Calibrated functional magnetic resonance imaging (fMRI) provides a noninvasive technique to assess functional metabolic changes associated with normal aging....
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SubjectTerms Adult
aging
Aging - physiology
Biological and medical sciences
blood oxygen level dependent (BOLD) effect
Brain Mapping
Cardiovascular system
cerebral blood flow (CBF)
cerebral metabolic rate of oxygen (CMRO2)
Cerebrovascular Circulation - physiology
Female
functional magnetic resonance imaging (fMRI)
Humans
Hypercapnia - metabolism
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Nervous system
Nonlinear Dynamics
Oxygen - blood
Oxygen Consumption - physiology
Photic Stimulation - methods
Radiodiagnosis. Nmr imagery. Nmr spectrometry
visual cortex
Visual Cortex - blood supply
Visual Cortex - physiology
Young Adult
Title Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation
URI https://api.istex.fr/ark:/67375/WNG-1C6WJDQH-1/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhbm.20574
https://www.ncbi.nlm.nih.gov/pubmed/18465743
https://www.proquest.com/docview/20420850
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https://pubmed.ncbi.nlm.nih.gov/PMC2810490
Volume 30
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