Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making

• Published in: Human brain mapping Vol. 28; no. 12; pp. 1276 - 1286
• Main Authors: Tanabe, Jody, Thompson, Laetitia, Claus, Eric, Dalwani, Manish, Hutchison, Kent, Banich, Marie T.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2007; Wiley-Liss
• Subjects: Adult; Biological and medical sciences; Cues; Decision Making - physiology; decision-making; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Electrodiagnosis. Electric activity recording; Exploratory Behavior - physiology; Feedback, Psychological - physiology; Female; fMRI; Fundamental and applied biological sciences. Psychology; Gambling - psychology; Humans; Image Processing, Computer-Assisted; Impulsive Behavior - psychology; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Medical sciences; Miscellaneous. Technology; Models, Neurological; Nervous system; Neuropsychological Tests; pathological gambling; prefrontal cortex; Prefrontal Cortex - physiology; Psychiatric Status Rating Scales; Psychomotor Performance - physiology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; substance abuse; Substance-Related Disorders - physiopathology; Substance-Related Disorders - psychology; Surveys and Questionnaires; Vertebrates: nervous system and sense organs; Wechsler Scales; Nervous system diseases; User; Abuse; Radiodiagnosis; Decision making; Central nervous system; Prefrontal cortex; Nuclear magnetic resonance imaging; Encephalon; fMRI; pathological gambling; decision-making; substance abuse

Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance‐dependence, and pathological gamb...