Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making

Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance‐dependence, and pathological gamb...

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Published inHuman brain mapping Vol. 28; no. 12; pp. 1276 - 1286
Main Authors Tanabe, Jody, Thompson, Laetitia, Claus, Eric, Dalwani, Manish, Hutchison, Kent, Banich, Marie T.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2007
Wiley-Liss
Subjects
Adult
Biological and medical sciences
Cues
Decision Making - physiology
decision-making
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Electrodiagnosis. Electric activity recording
Exploratory Behavior - physiology
Feedback, Psychological - physiology
Female
fMRI
Fundamental and applied biological sciences. Psychology
Gambling - psychology
Humans
Image Processing, Computer-Assisted
Impulsive Behavior - psychology
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Miscellaneous. Technology
Models, Neurological
Nervous system
Neuropsychological Tests
pathological gambling
prefrontal cortex
Prefrontal Cortex - physiology
Psychiatric Status Rating Scales
Psychomotor Performance - physiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
substance abuse
Substance-Related Disorders - physiopathology
Substance-Related Disorders - psychology
Surveys and Questionnaires
Vertebrates: nervous system and sense organs
Wechsler Scales
Nervous system diseases
User
Abuse
Radiodiagnosis
Decision making
Central nervous system
Prefrontal cortex
Nuclear magnetic resonance imaging
Encephalon
fMRI
pathological gambling
decision-making
substance abuse
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Abstract Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance‐dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance‐dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems. Method: 18 controls, 14 substance‐dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT. Result: Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision‐making. Controls showed the greatest activity, followed by SDPG, followed by SD. Conclusion: Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision‐making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance‐dependent individuals. Hum Brain Mapp, 2007. © 2007 Wiley‐Liss, Inc.
AbstractList Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems. 18 controls, 14 substance-dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT. Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision-making. Controls showed the greatest activity, followed by SDPG, followed by SD. Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision-making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance-dependent individuals.
Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems.OBJECTIVEPoor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems.18 controls, 14 substance-dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT.METHOD18 controls, 14 substance-dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT.Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision-making. Controls showed the greatest activity, followed by SDPG, followed by SD.RESULTGroup differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision-making. Controls showed the greatest activity, followed by SDPG, followed by SD.Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision-making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance-dependent individuals.CONCLUSIONOur results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision-making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance-dependent individuals.
Objective: Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance-dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance-dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems. Method: 18 controls, 14 substance-dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT. Result: Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision-making. Controls showed the greatest activity, followed by SDPG, followed by SD. Conclusion: Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision-making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance-dependent individuals. Hum Brain Mapp, 2007.
Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance‐dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance‐dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems. Method: 18 controls, 14 substance‐dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT. Result: Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision‐making. Controls showed the greatest activity, followed by SDPG, followed by SD. Conclusion: Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision‐making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance‐dependent individuals. Hum Brain Mapp, 2007. © 2007 Wiley‐Liss, Inc.
Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa Gambling Task (IGT), can discriminate controls from persons with ventral medial frontal lesions, substance‐dependence, and pathological gambling. Positron emission tomography (PET) studies indicate that substance‐dependent individuals show altered prefrontal activity on the task. Here we adapted the IGT to an fMRI setting to test the hypothesis that defects in ventral medial and prefrontal processing are associated with impaired decisions that involve risk but may differ depending on whether substance dependence is comorbid with gambling problems. Method: 18 controls, 14 substance‐dependent individuals (SD), and 16 SD with gambling problems (SDPG) underwent fMRI while performing a modified version of the IGT. Result: Group differences were observed in ventral medial frontal, right frontopolar, and superior frontal cortex during decision‐making. Controls showed the greatest activity, followed by SDPG, followed by SD. Conclusion: Our results support a hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk. Reductions in right prefrontal activity during decision‐making appear to be modulated by the presence of gambling problems and may reflect impaired working memory, stimulus reward valuation, or cue reactivity in substance‐dependent individuals. Hum Brain Mapp, 2007. © 2007 Wiley‐Liss, Inc.
Author Claus, Eric
Dalwani, Manish
Tanabe, Jody
Thompson, Laetitia
Banich, Marie T.
Hutchison, Kent
AuthorAffiliation 2 Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
1 Department of Radiology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
3 Department of Psychology, University of Colorado Boulder, Colorado
AuthorAffiliation_xml – name: 2 Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
– name: 3 Department of Psychology, University of Colorado Boulder, Colorado
– name: 1 Department of Radiology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
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  surname: Tanabe
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– sequence: 2
  givenname: Laetitia
  surname: Thompson
  fullname: Thompson, Laetitia
  organization: Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
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  givenname: Eric
  surname: Claus
  fullname: Claus, Eric
  organization: Department of Psychology, University of Colorado Boulder, Colorado
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  surname: Banich
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  organization: Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Denver, Colorado
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Cites_doi 10.1016/S0893-133X(01)00414-6
10.1177/01461672002612002
10.1037/0894-4105.18.1.152
10.1016/S1053-8119(03)00113-7
10.1037/0021-843X.110.3.482
10.1016/j.biopsych.2005.04.037
10.1001/archpsyc.61.1.73
10.1016/S0893-133X(01)00334-7
10.1016/j.neuroimage.2005.02.012
10.1016/0376-8716(94)01091-X
10.1006/nimg.2000.0593
10.1016/S0028-3932(03)00081-2
10.1162/0898929053747694
10.1176/ajp.144.9.1184
10.1038/82959
10.1126/science.1069504
10.1016/j.cogbrainres.2005.01.010
10.1016/j.cogbrainres.2004.12.010
10.1016/S0896-6273(01)00303-8
10.4088/JCP.v66n0504
10.1002/hbm.20202
10.1093/brain/awf049
10.1016/0028-3932(91)90037-9
10.1038/nature01138
10.1093/brain/123.11.2189
10.1016/S0140-1971(03)00036-8
10.1523/JNEUROSCI.19-20-09029.1999
10.1016/j.pneurobio.2004.03.006
10.1016/j.brat.2003.12.007
10.1016/0010-0277(94)90018-3
10.1037/1040-3590.14.3.253
10.1037/0893-164X.19.2.148
10.1002/(SICI)1098-2396(199611)24:3<308::AID-SYN14>3.0.CO;2-S
10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1
10.1016/S0028-3932(98)00107-9
10.1523/JNEUROSCI.0433-05.2005
10.1093/cercor/10.3.334
10.1016/S0893-133X(98)00091-8
10.1016/S0006-3223(02)01442-7
10.1176/appi.ajp.162.8.1403
10.1523/JNEUROSCI.20-16-06159.2000
10.1176/appi.ajp.160.1.33
10.1016/S0376-8716(00)00188-5
10.1016/j.neuroimage.2004.08.028
10.1037/0033-295X.113.2.300
10.1016/j.conb.2004.10.016
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Issue 12
Keywords Nervous system diseases
User
Abuse
Radiodiagnosis
Decision making
Central nervous system
Prefrontal cortex
Nuclear magnetic resonance imaging
Encephalon
fMRI
pathological gambling
decision-making
substance abuse
Language English
License http://onlinelibrary.wiley.com/termsAndConditions#vor
CC BY 4.0
(copyright) 2007 Wiley-Liss, Inc.
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Institute for Research on Pathological Gambling and Related Disorders, Harvard Medical School, Division of Addictions
Presented at the Organization for Human Brain Mapping 2006, Florence, Italy.
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PublicationTitle Human brain mapping
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References Paulus MP,Hozack NE,Zauscher BE,Frank L,Brown GG,Braff DL,Schuckit MA ( 2002): Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology 26: 53-63.
Busemeyer JR,Stout JC ( 2002): A contribution of cognitive decision models to clinical assessment: Decomposing performance on the Bechara gambling task. Psychol Assess 14: 253-262.
Frank MJ,Claus ED ( 2006): Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. Psychol Rev 113: 300-326.
Petry NM ( 2001a): Pathological gamblers, with and without substance use disorders, discount delayed rewards at high rates. J Abnorm Psychol 110: 482-487.
Elliott R,Friston KJ,Dolan RJ ( 2000): Dissociable neural responses in human reward systems. J Neurosci 20: 6159-6165.
London ED,Ernst M,Grant S,Bonson K,Weinstein A ( 2000): Orbitofrontal cortex and human drug abuse: Functional imaging. Cereb Cortex 10: 334-342.
London ED,Simon SL,Berman SM,Mandelkern MA,Lichtman AM,Bramen J,Shinn AK,Miotto K,Learn J,Dong Y,Matochik JA,Kurian V,Newton T,Woods R,Rawson R,Ling W ( 2004): Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch Gen Psychiatry 61: 73-84.
Stout JC,Rock SL,Campbell MC,Busemeyer JR,Finn PR ( 2005): Psychological processes underlying risky decisions in drug abusers. Psychol Addict Behav 19: 148-157.
Rogers RD,Everitt BJ,Baldacchino A,Blackshaw AJ,Swainson R,Wynne K,Baker NB,Hunter J,Carthy T,Booker E,London M,Deakin JF,Sahakian BJ,Robbins TW ( 1999a): Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology 20: 322-339.
Petry NM ( 2001b): Substance abuse, pathological gambling, and impulsiveness. Drug Alcohol Depend 63: 29-38.
Saver JL,Damasio AR ( 1991): Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia 29: 1241-1249.
Patton JH,Stanford MS,Barratt ES ( 1995): Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51: 768-774.
Shidara M,Richmond BJ ( 2002): Anterior cingulate: Single neuronal signals related to degree of reward expectancy. Science 296: 1709-1711.
Cottler LB,Schuckit MA,Helzer JE,Crowley T,Woody G,Nathan P,Hughes J ( 1995): The DSM-IV field trial for substance use disorders: Major results. Drug Alcohol Depend 38: 59-69.
Milad MR,Quirk GJ ( 2002): Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420: 70-74.
Bolla KI,Eldreth DA,Matochik JA,Cadet JL ( 2005): Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage 26: 480-492.
Clark L,Manes F,Antoun N,Sahakian BJ,Robbins TW ( 2003): The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage. Neuropsychologia 41: 1474-1483.
Bechara A,Martin EM (2004): Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology 18: 152-162.
Bechara A,Damasio AR,Damasio H,Anderson SW ( 1994): Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15.
Fukui H,Murai T,Fukuyama H,Hayashi T,Hanakawa T ( 2005): Functional activity related to risk anticipation during performance of the Iowa gambling task. Neuroimage 24: 253-259.
Knutson B,Adams CM,Fong GW,Hommer D ( 2001): Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21(RC159): 1-5.
Rogers RD,Owen AM,Middleton HC,Williams EJ,Pickard JD,Sahakian BJ,Robbins TW ( 1999b): Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J Neurosci 19: 9029-9038.
Bolla KI,Eldreth DA,London ED,Kiehl KA,Mouratidis M,Contoreggi C,Matochik JA,Kurian V,Cadet JL,Kimes AS,Funderburk FR,Ernst M ( 2003): Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19: 1085-1094.
Crockford DN,Goodyear B,Edwards J,Quickfall J,El Guebaly N ( 2005): Cue-induced brain activity in pathological gamblers. Biol Psych 58: 787-795.
Ernst M,Bolla K,Mouratidis M,Contoreggi C,Matochik JA,Kurian V,Cadet JL,Kimes AS,London ED ( 2002): Decision-making in a risk-taking task: A PET study. Neuropsychopharmacology 26: 682-691.
Cohen MX,Heller AS,Ranganath C ( 2005): Functional connectivity with anterior cingulate and orbitofrontal cortices during decision-making. Brain Res Cogn Brain Res 23: 61-70.
Lejuez CW,Aklin WM,Zvolensky MJ,Pedulla CM ( 2003): Evaluation of the balloon analogue risk task (BART) as a predictor of adolescent real-world risk-taking behaviours. J Adolesc 26: 475-479.
O'Doherty JP ( 2004): Reward representations and reward-related learning in the human brain: Insights from neuroimaging. Curr Opin Neurobiol 14: 769-776.
Northoff G,Grimm S,Boeker H,Schmidt C,Bermpohl F,Heinzel A,Hell D,Boesiger P ( 2006): Affective judgment and beneficial decision making: Ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task. Hum Brain Mapp 27: 572-587.
Paulus MP,Hozack N,Frank L,Brown GG,Schuckit MA ( 2003): Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation. Biol Psychiatry 53: 65-74.
Carelli RM,Deadwyler SA ( 1996): Dual factors controlling activity of nucleus accumbens cell-firing during cocaine self-administration. Synapse 24: 308-311.
Kringelbach ML,Rolls ET ( 2004): The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Prog Neurobiol 72: 341-372.
Aklin WM,Lejuez CW,Zvolensky MJ,Kahler CW,Gwadz M ( 2005): Evaluation of behavioral measures of risk taking propensity with inner city adolescents. Behav Res Ther 43: 215-228.
Elliott R,Rees G,Dolan RJ (1999):Ventromedial prefrontal cortex mediates guessing.Neuropsychologia 37: 403-411.
Knutson B,Westdorp A,Kaiser E,Hommer D ( 2000): FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12: 20-27.
Kalivas PW,Volkow ND ( 2005): The neural basis of addiction: A pathology of motivation and choice. Am J Psychiatry 162: 1403-1413.
Lesieur HR,Blume SB ( 1987): The South Oaks Gambling Screen (SOGS): A new instrument for the identification of pathological gamblers. Am J Psychiatry 144: 1184-1188.
Volkow ND,Wang GJ,Ma Y,Fowler JS,Wong C,Ding YS,Hitzemann R,Swanson JM,Kalivas P ( 2005): Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: Relevance to addiction. JNeurosci 25: 3932-3939.
Manes F,Sahakian B,Clark L,Rogers R,Antoun N,Aitken M,Robbins T ( 2002): Decision-making processes following damage to the prefrontal cortex. Brain 125: 624-639.
Ernst M,Grant SJ,London ED,Contoreggi CS,Kimes AS,Spurgeon L ( 2003): Decision making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry 160: 33-40.
Fishbein DH,Eldreth DL,Hyde C,Matochik JA,London ED,Contoreggi C,Kurian V,Kimes AS,Breeden A,Grant S ( 2005): Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers. Brain Res Cogn Brain Res 23: 119-136.
Petry NM,Stinson FS,Grant BF ( 2005): Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: Results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry 66: 564-574.
Peters E,Slovic P ( 2003): The springs of action: Affective and analytical information processing in choice. Pers Soc Psychol 26: 1465-1475.
O'Doherty J,Kringelbach ML,Rolls ET,Hornak J,Andrews C ( 2001): Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci 4: 95-102.
Schnyer DM,Nicholls L,Verfaellie M ( 2005): The role of VMPC in metamemorial judgments of content retrievability. J Cogn Neurosci 17: 832-846.
Banich M ( 2004): Cognitive Neuroscience and Neuropsychology, 2nd ed. Houghton Mifflin Co., Boston, MA, 252-285.
Bechara A,Tranel D,Damasio H ( 2000): Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123 (Part 11): 2189-2202.
Breiter HC,Aharon I,Kahneman D,Dale A,Shizgal P ( 2001): Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30: 619-639.
2002; 14
1995; 51
2004; 61
1999b; 19
1987; 144
2002; 296
1995; 38
2000; 20
2005; 43
2004
2003; 19
2005; 26
2001b; 63
2003; 53
2005; 66
2005; 23
2005; 24
2006; 113
2001; 21
1999
2005; 25
2001a; 110
1991; 29
2002; 26
2004; 72
2005; 19
2005; 162
2004; 18
1999a; 20
2000; 12
2001; 4
2000; 10
2006; 27
2004; 14
2002; 125
1999; 37
2002; 420
2003; 160
2003; 26
2000; 123
1996; 24
1994; 50
2005; 17
2003; 41
2001; 30
2005; 58
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References_xml – reference: Ernst M,Grant SJ,London ED,Contoreggi CS,Kimes AS,Spurgeon L ( 2003): Decision making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry 160: 33-40.
– reference: Bechara A,Damasio AR,Damasio H,Anderson SW ( 1994): Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50: 7-15.
– reference: Petry NM ( 2001b): Substance abuse, pathological gambling, and impulsiveness. Drug Alcohol Depend 63: 29-38.
– reference: Paulus MP,Hozack N,Frank L,Brown GG,Schuckit MA ( 2003): Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation. Biol Psychiatry 53: 65-74.
– reference: Fishbein DH,Eldreth DL,Hyde C,Matochik JA,London ED,Contoreggi C,Kurian V,Kimes AS,Breeden A,Grant S ( 2005): Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers. Brain Res Cogn Brain Res 23: 119-136.
– reference: Rogers RD,Everitt BJ,Baldacchino A,Blackshaw AJ,Swainson R,Wynne K,Baker NB,Hunter J,Carthy T,Booker E,London M,Deakin JF,Sahakian BJ,Robbins TW ( 1999a): Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology 20: 322-339.
– reference: Bechara A,Tranel D,Damasio H ( 2000): Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123 (Part 11): 2189-2202.
– reference: Elliott R,Friston KJ,Dolan RJ ( 2000): Dissociable neural responses in human reward systems. J Neurosci 20: 6159-6165.
– reference: Carelli RM,Deadwyler SA ( 1996): Dual factors controlling activity of nucleus accumbens cell-firing during cocaine self-administration. Synapse 24: 308-311.
– reference: Volkow ND,Wang GJ,Ma Y,Fowler JS,Wong C,Ding YS,Hitzemann R,Swanson JM,Kalivas P ( 2005): Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: Relevance to addiction. JNeurosci 25: 3932-3939.
– reference: Knutson B,Adams CM,Fong GW,Hommer D ( 2001): Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 21(RC159): 1-5.
– reference: O'Doherty J,Kringelbach ML,Rolls ET,Hornak J,Andrews C ( 2001): Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci 4: 95-102.
– reference: Ernst M,Bolla K,Mouratidis M,Contoreggi C,Matochik JA,Kurian V,Cadet JL,Kimes AS,London ED ( 2002): Decision-making in a risk-taking task: A PET study. Neuropsychopharmacology 26: 682-691.
– reference: London ED,Ernst M,Grant S,Bonson K,Weinstein A ( 2000): Orbitofrontal cortex and human drug abuse: Functional imaging. Cereb Cortex 10: 334-342.
– reference: Petry NM,Stinson FS,Grant BF ( 2005): Comorbidity of DSM-IV pathological gambling and other psychiatric disorders: Results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry 66: 564-574.
– reference: Stout JC,Rock SL,Campbell MC,Busemeyer JR,Finn PR ( 2005): Psychological processes underlying risky decisions in drug abusers. Psychol Addict Behav 19: 148-157.
– reference: Saver JL,Damasio AR ( 1991): Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage. Neuropsychologia 29: 1241-1249.
– reference: Shidara M,Richmond BJ ( 2002): Anterior cingulate: Single neuronal signals related to degree of reward expectancy. Science 296: 1709-1711.
– reference: Crockford DN,Goodyear B,Edwards J,Quickfall J,El Guebaly N ( 2005): Cue-induced brain activity in pathological gamblers. Biol Psych 58: 787-795.
– reference: Elliott R,Rees G,Dolan RJ (1999):Ventromedial prefrontal cortex mediates guessing.Neuropsychologia 37: 403-411.
– reference: Paulus MP,Hozack NE,Zauscher BE,Frank L,Brown GG,Braff DL,Schuckit MA ( 2002): Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology 26: 53-63.
– reference: Schnyer DM,Nicholls L,Verfaellie M ( 2005): The role of VMPC in metamemorial judgments of content retrievability. J Cogn Neurosci 17: 832-846.
– reference: Knutson B,Westdorp A,Kaiser E,Hommer D ( 2000): FMRI visualization of brain activity during a monetary incentive delay task. Neuroimage 12: 20-27.
– reference: Northoff G,Grimm S,Boeker H,Schmidt C,Bermpohl F,Heinzel A,Hell D,Boesiger P ( 2006): Affective judgment and beneficial decision making: Ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task. Hum Brain Mapp 27: 572-587.
– reference: Bolla KI,Eldreth DA,Matochik JA,Cadet JL ( 2005): Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage 26: 480-492.
– reference: Frank MJ,Claus ED ( 2006): Anatomy of a decision: Striato-orbitofrontal interactions in reinforcement learning, decision making, and reversal. Psychol Rev 113: 300-326.
– reference: Petry NM ( 2001a): Pathological gamblers, with and without substance use disorders, discount delayed rewards at high rates. J Abnorm Psychol 110: 482-487.
– reference: Peters E,Slovic P ( 2003): The springs of action: Affective and analytical information processing in choice. Pers Soc Psychol 26: 1465-1475.
– reference: Rogers RD,Owen AM,Middleton HC,Williams EJ,Pickard JD,Sahakian BJ,Robbins TW ( 1999b): Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J Neurosci 19: 9029-9038.
– reference: Milad MR,Quirk GJ ( 2002): Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420: 70-74.
– reference: Breiter HC,Aharon I,Kahneman D,Dale A,Shizgal P ( 2001): Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron 30: 619-639.
– reference: Cohen MX,Heller AS,Ranganath C ( 2005): Functional connectivity with anterior cingulate and orbitofrontal cortices during decision-making. Brain Res Cogn Brain Res 23: 61-70.
– reference: Cottler LB,Schuckit MA,Helzer JE,Crowley T,Woody G,Nathan P,Hughes J ( 1995): The DSM-IV field trial for substance use disorders: Major results. Drug Alcohol Depend 38: 59-69.
– reference: Busemeyer JR,Stout JC ( 2002): A contribution of cognitive decision models to clinical assessment: Decomposing performance on the Bechara gambling task. Psychol Assess 14: 253-262.
– reference: Lesieur HR,Blume SB ( 1987): The South Oaks Gambling Screen (SOGS): A new instrument for the identification of pathological gamblers. Am J Psychiatry 144: 1184-1188.
– reference: Fukui H,Murai T,Fukuyama H,Hayashi T,Hanakawa T ( 2005): Functional activity related to risk anticipation during performance of the Iowa gambling task. Neuroimage 24: 253-259.
– reference: Kalivas PW,Volkow ND ( 2005): The neural basis of addiction: A pathology of motivation and choice. Am J Psychiatry 162: 1403-1413.
– reference: Manes F,Sahakian B,Clark L,Rogers R,Antoun N,Aitken M,Robbins T ( 2002): Decision-making processes following damage to the prefrontal cortex. Brain 125: 624-639.
– reference: Banich M ( 2004): Cognitive Neuroscience and Neuropsychology, 2nd ed. Houghton Mifflin Co., Boston, MA, 252-285.
– reference: Bolla KI,Eldreth DA,London ED,Kiehl KA,Mouratidis M,Contoreggi C,Matochik JA,Kurian V,Cadet JL,Kimes AS,Funderburk FR,Ernst M ( 2003): Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19: 1085-1094.
– reference: Lejuez CW,Aklin WM,Zvolensky MJ,Pedulla CM ( 2003): Evaluation of the balloon analogue risk task (BART) as a predictor of adolescent real-world risk-taking behaviours. J Adolesc 26: 475-479.
– reference: Aklin WM,Lejuez CW,Zvolensky MJ,Kahler CW,Gwadz M ( 2005): Evaluation of behavioral measures of risk taking propensity with inner city adolescents. Behav Res Ther 43: 215-228.
– reference: O'Doherty JP ( 2004): Reward representations and reward-related learning in the human brain: Insights from neuroimaging. Curr Opin Neurobiol 14: 769-776.
– reference: London ED,Simon SL,Berman SM,Mandelkern MA,Lichtman AM,Bramen J,Shinn AK,Miotto K,Learn J,Dong Y,Matochik JA,Kurian V,Newton T,Woods R,Rawson R,Ling W ( 2004): Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch Gen Psychiatry 61: 73-84.
– reference: Kringelbach ML,Rolls ET ( 2004): The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Prog Neurobiol 72: 341-372.
– reference: Bechara A,Martin EM (2004): Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology 18: 152-162.
– reference: Clark L,Manes F,Antoun N,Sahakian BJ,Robbins TW ( 2003): The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage. Neuropsychologia 41: 1474-1483.
– reference: Patton JH,Stanford MS,Barratt ES ( 1995): Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51: 768-774.
– volume: 113
  start-page: 300
  year: 2006
  end-page: 326
  article-title: Anatomy of a decision: Striato‐orbitofrontal interactions in reinforcement learning, decision making, and reversal
  publication-title: Psychol Rev
– volume: 123
  start-page: 2189
  year: 2000
  end-page: 2202
  article-title: Characterization of the decision‐making deficit of patients with ventromedial prefrontal cortex lesions
  publication-title: Brain
– volume: 41
  start-page: 1474
  year: 2003
  end-page: 1483
  article-title: The contributions of lesion laterality and lesion volume to decision‐making impairment following frontal lobe damage
  publication-title: Neuropsychologia
– volume: 51
  start-page: 768
  year: 1995
  end-page: 774
  article-title: Factor structure of the Barratt impulsiveness scale
  publication-title: J Clin Psychol
– volume: 110
  start-page: 482
  year: 2001a
  end-page: 487
  article-title: Pathological gamblers, with and without substance use disorders, discount delayed rewards at high rates
  publication-title: J Abnorm Psychol
– volume: 20
  start-page: 6159
  year: 2000
  end-page: 6165
  article-title: Dissociable neural responses in human reward systems
  publication-title: J Neurosci
– volume: 43
  start-page: 215
  year: 2005
  end-page: 228
  article-title: Evaluation of behavioral measures of risk taking propensity with inner city adolescents
  publication-title: Behav Res Ther
– volume: 23
  start-page: 61
  year: 2005
  end-page: 70
  article-title: Functional connectivity with anterior cingulate and orbitofrontal cortices during decision‐making
  publication-title: Brain Res Cogn Brain Res
– volume: 162
  start-page: 1403
  year: 2005
  end-page: 1413
  article-title: The neural basis of addiction: A pathology of motivation and choice
  publication-title: Am J Psychiatry
– volume: 27
  start-page: 572
  year: 2006
  end-page: 587
  article-title: Affective judgment and beneficial decision making: Ventromedial prefrontal activity correlates with performance in the Iowa Gambling Task
  publication-title: Hum Brain Mapp
– volume: 19
  start-page: 148
  year: 2005
  end-page: 157
  article-title: Psychological processes underlying risky decisions in drug abusers
  publication-title: Psychol Addict Behav
– volume: 72
  start-page: 341
  year: 2004
  end-page: 372
  article-title: The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology
  publication-title: Prog Neurobiol
– volume: 37
  start-page: 403
  year: 1999
  end-page: 411
  article-title: Ventromedial prefrontal cortex mediates guessing
  publication-title: Neuropsychologia
– volume: 24
  start-page: 253
  year: 2005
  end-page: 259
  article-title: Functional activity related to risk anticipation during performance of the Iowa gambling task
  publication-title: Neuroimage
– volume: 21
  start-page: 1
  issue: RC159
  year: 2001
  end-page: 5
  article-title: Anticipation of increasing monetary reward selectively recruits nucleus accumbens
  publication-title: J Neurosci
– volume: 17
  start-page: 832
  year: 2005
  end-page: 846
  article-title: The role of VMPC in metamemorial judgments of content retrievability
  publication-title: J Cogn Neurosci
– volume: 125
  start-page: 624
  year: 2002
  end-page: 639
  article-title: Decision‐making processes following damage to the prefrontal cortex
  publication-title: Brain
– volume: 19
  start-page: 1085
  year: 2003
  end-page: 1094
  article-title: Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision‐making task
  publication-title: Neuroimage
– volume: 63
  start-page: 29
  year: 2001b
  end-page: 38
  article-title: Substance abuse, pathological gambling, and impulsiveness
  publication-title: Drug Alcohol Depend
– start-page: 252
  year: 2004
  end-page: 285
– volume: 25
  start-page: 3932
  year: 2005
  end-page: 3939
  article-title: Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine‐addicted subjects but not in controls: Relevance to addiction
  publication-title: JNeurosci
– volume: 12
  start-page: 20
  year: 2000
  end-page: 27
  article-title: FMRI visualization of brain activity during a monetary incentive delay task
  publication-title: Neuroimage
– volume: 66
  start-page: 564
  year: 2005
  end-page: 574
  article-title: Comorbidity of DSM‐IV pathological gambling and other psychiatric disorders: Results from the national epidemiologic survey on alcohol and related conditions
  publication-title: J Clin Psychiatry
– volume: 30
  start-page: 619
  year: 2001
  end-page: 639
  article-title: Functional imaging of neural responses to expectancy and experience of monetary gains and losses
  publication-title: Neuron
– volume: 420
  start-page: 70
  year: 2002
  end-page: 74
  article-title: Neurons in medial prefrontal cortex signal memory for fear extinction
  publication-title: Nature
– volume: 14
  start-page: 253
  year: 2002
  end-page: 262
  article-title: A contribution of cognitive decision models to clinical assessment: Decomposing performance on the Bechara gambling task
  publication-title: Psychol Assess
– volume: 58
  start-page: 787
  year: 2005
  end-page: 795
  article-title: Cue‐induced brain activity in pathological gamblers
  publication-title: Biol Psych
– volume: 14
  start-page: 769
  year: 2004
  end-page: 776
  article-title: Reward representations and reward‐related learning in the human brain: Insights from neuroimaging
  publication-title: Curr Opin Neurobiol
– volume: 24
  start-page: 308
  year: 1996
  end-page: 311
  article-title: Dual factors controlling activity of nucleus accumbens cell‐firing during cocaine self‐administration
  publication-title: Synapse
– volume: 26
  start-page: 682
  year: 2002
  end-page: 691
  article-title: Decision‐making in a risk‐taking task: A PET study
  publication-title: Neuropsychopharmacology
– volume: 61
  start-page: 73
  year: 2004
  end-page: 84
  article-title: Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers
  publication-title: Arch Gen Psychiatry
– volume: 26
  start-page: 53
  year: 2002
  end-page: 63
  article-title: Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine‐dependent subjects
  publication-title: Neuropsychopharmacology
– volume: 160
  start-page: 33
  year: 2003
  end-page: 40
  article-title: Decision making in adolescents with behavior disorders and adults with substance abuse
  publication-title: Am J Psychiatry
– volume: 144
  start-page: 1184
  year: 1987
  end-page: 1188
  article-title: The South Oaks Gambling Screen (SOGS): A new instrument for the identification of pathological gamblers
  publication-title: Am J Psychiatry
– volume: 4
  start-page: 95
  year: 2001
  end-page: 102
  article-title: Abstract reward and punishment representations in the human orbitofrontal cortex
  publication-title: Nat Neurosci
– volume: 53
  start-page: 65
  year: 2003
  end-page: 74
  article-title: Decision making by methamphetamine‐dependent subjects is associated with error‐rate‐independent decrease in prefrontal and parietal activation
  publication-title: Biol Psychiatry
– volume: 29
  start-page: 1241
  year: 1991
  end-page: 1249
  article-title: Preserved access and processing of social knowledge in a patient with acquired sociopathy due to ventromedial frontal damage
  publication-title: Neuropsychologia
– volume: 18
  start-page: 152
  year: 2004
  end-page: 162
  article-title: Impaired decision making related to working memory deficits in individuals with substance addictions
  publication-title: Neuropsychology
– volume: 26
  start-page: 1465
  year: 2003
  end-page: 1475
  article-title: The springs of action: Affective and analytical information processing in choice
  publication-title: Pers Soc Psychol
– volume: 26
  start-page: 480
  year: 2005
  end-page: 492
  article-title: Neural substrates of faulty decision‐making in abstinent marijuana users
  publication-title: Neuroimage
– volume: 50
  start-page: 7
  year: 1994
  end-page: 15
  article-title: Insensitivity to future consequences following damage to human prefrontal cortex
  publication-title: Cognition
– volume: 38
  start-page: 59
  year: 1995
  end-page: 69
  article-title: The DSM‐IV field trial for substance use disorders: Major results
  publication-title: Drug Alcohol Depend
– volume: 19
  start-page: 9029
  year: 1999b
  end-page: 9038
  article-title: Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex
  publication-title: J Neurosci
– volume: 10
  start-page: 334
  year: 2000
  end-page: 342
  article-title: Orbitofrontal cortex and human drug abuse: Functional imaging
  publication-title: Cereb Cortex
– volume: 296
  start-page: 1709
  year: 2002
  end-page: 1711
  article-title: Anterior cingulate: Single neuronal signals related to degree of reward expectancy
  publication-title: Science
– volume: 26
  start-page: 475
  year: 2003
  end-page: 479
  article-title: Evaluation of the balloon analogue risk task (BART) as a predictor of adolescent real‐world risk‐taking behaviours
  publication-title: J Adolesc
– volume: 23
  start-page: 119
  year: 2005
  end-page: 136
  article-title: Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers
  publication-title: Brain Res Cogn Brain Res
– volume: 20
  start-page: 322
  year: 1999a
  end-page: 339
  article-title: Dissociable deficits in the decision‐making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan‐depleted normal volunteers: Evidence for monoaminergic mechanisms
  publication-title: Neuropsychopharmacology
– year: 1999
– ident: e_1_2_7_18_1
  doi: 10.1016/S0893-133X(01)00414-6
– volume: 26
  start-page: 1465
  year: 2003
  ident: e_1_2_7_39_1
  article-title: The springs of action: Affective and analytical information processing in choice
  publication-title: Pers Soc Psychol
  doi: 10.1177/01461672002612002
– ident: e_1_2_7_4_1
  doi: 10.1037/0894-4105.18.1.152
– ident: e_1_2_7_7_1
  doi: 10.1016/S1053-8119(03)00113-7
– ident: e_1_2_7_40_1
  doi: 10.1037/0021-843X.110.3.482
– ident: e_1_2_7_15_1
  doi: 10.1016/j.biopsych.2005.04.037
– ident: e_1_2_7_30_1
  doi: 10.1001/archpsyc.61.1.73
– ident: e_1_2_7_38_1
  doi: 10.1016/S0893-133X(01)00334-7
– ident: e_1_2_7_8_1
  doi: 10.1016/j.neuroimage.2005.02.012
– ident: e_1_2_7_14_1
  doi: 10.1016/0376-8716(94)01091-X
– ident: e_1_2_7_24_1
  doi: 10.1006/nimg.2000.0593
– ident: e_1_2_7_12_1
  doi: 10.1016/S0028-3932(03)00081-2
– ident: e_1_2_7_47_1
  doi: 10.1162/0898929053747694
– ident: e_1_2_7_28_1
  doi: 10.1176/ajp.144.9.1184
– ident: e_1_2_7_35_1
  doi: 10.1038/82959
– ident: e_1_2_7_48_1
  doi: 10.1126/science.1069504
– ident: e_1_2_7_13_1
  doi: 10.1016/j.cogbrainres.2005.01.010
– ident: e_1_2_7_20_1
  doi: 10.1016/j.cogbrainres.2004.12.010
– ident: e_1_2_7_9_1
  doi: 10.1016/S0896-6273(01)00303-8
– ident: e_1_2_7_42_1
  doi: 10.4088/JCP.v66n0504
– ident: e_1_2_7_43_1
– ident: e_1_2_7_33_1
  doi: 10.1002/hbm.20202
– ident: e_1_2_7_31_1
  doi: 10.1093/brain/awf049
– ident: e_1_2_7_46_1
  doi: 10.1016/0028-3932(91)90037-9
– ident: e_1_2_7_32_1
  doi: 10.1038/nature01138
– ident: e_1_2_7_6_1
  doi: 10.1093/brain/123.11.2189
– ident: e_1_2_7_27_1
  doi: 10.1016/S0140-1971(03)00036-8
– ident: e_1_2_7_45_1
  doi: 10.1523/JNEUROSCI.19-20-09029.1999
– ident: e_1_2_7_26_1
  doi: 10.1016/j.pneurobio.2004.03.006
– ident: e_1_2_7_2_1
  doi: 10.1016/j.brat.2003.12.007
– ident: e_1_2_7_5_1
  doi: 10.1016/0010-0277(94)90018-3
– ident: e_1_2_7_10_1
  doi: 10.1037/1040-3590.14.3.253
– start-page: 252
  volume-title: Cognitive Neuroscience and Neuropsychology
  year: 2004
  ident: e_1_2_7_3_1
– ident: e_1_2_7_49_1
  doi: 10.1037/0893-164X.19.2.148
– ident: e_1_2_7_11_1
  doi: 10.1002/(SICI)1098-2396(199611)24:3<308::AID-SYN14>3.0.CO;2-S
– ident: e_1_2_7_36_1
  doi: 10.1002/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1
– ident: e_1_2_7_16_1
  doi: 10.1016/S0028-3932(98)00107-9
– ident: e_1_2_7_50_1
  doi: 10.1523/JNEUROSCI.0433-05.2005
– ident: e_1_2_7_29_1
  doi: 10.1093/cercor/10.3.334
– ident: e_1_2_7_44_1
  doi: 10.1016/S0893-133X(98)00091-8
– ident: e_1_2_7_37_1
  doi: 10.1016/S0006-3223(02)01442-7
– ident: e_1_2_7_23_1
  doi: 10.1176/appi.ajp.162.8.1403
– ident: e_1_2_7_17_1
  doi: 10.1523/JNEUROSCI.20-16-06159.2000
– ident: e_1_2_7_19_1
  doi: 10.1176/appi.ajp.160.1.33
– volume: 21
  start-page: 1
  issue: 159
  year: 2001
  ident: e_1_2_7_25_1
  article-title: Anticipation of increasing monetary reward selectively recruits nucleus accumbens
  publication-title: J Neurosci
– ident: e_1_2_7_41_1
  doi: 10.1016/S0376-8716(00)00188-5
– ident: e_1_2_7_22_1
  doi: 10.1016/j.neuroimage.2004.08.028
– ident: e_1_2_7_21_1
  doi: 10.1037/0033-295X.113.2.300
– ident: e_1_2_7_34_1
  doi: 10.1016/j.conb.2004.10.016
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Snippet Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa...
Objective: Poor decision‐making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision‐making, the Iowa...
Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa Gambling...
Objective: Poor decision-making is a hallmark of addiction, whether to substances or activities. Performance on a widely used test of decision-making, the Iowa...
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pubmed
pascalfrancis
crossref
wiley
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SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1276
SubjectTerms Adult
Biological and medical sciences
Cues
Decision Making - physiology
decision-making
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Electrodiagnosis. Electric activity recording
Exploratory Behavior - physiology
Feedback, Psychological - physiology
Female
fMRI
Fundamental and applied biological sciences. Psychology
Gambling - psychology
Humans
Image Processing, Computer-Assisted
Impulsive Behavior - psychology
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Miscellaneous. Technology
Models, Neurological
Nervous system
Neuropsychological Tests
pathological gambling
prefrontal cortex
Prefrontal Cortex - physiology
Psychiatric Status Rating Scales
Psychomotor Performance - physiology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
substance abuse
Substance-Related Disorders - physiopathology
Substance-Related Disorders - psychology
Surveys and Questionnaires
Vertebrates: nervous system and sense organs
Wechsler Scales
Title Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making
URI https://api.istex.fr/ark:/67375/WNG-GSKWDRQW-3/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhbm.20344
https://www.ncbi.nlm.nih.gov/pubmed/17274020
https://www.proquest.com/docview/20474066
https://www.proquest.com/docview/68522762
https://pubmed.ncbi.nlm.nih.gov/PMC6871281
Volume 28
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