Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

• Published in: British journal of pharmacology Vol. 154; no. 7; pp. 1439 - 1445
• Main Authors: Lynch, J J, Wilson, A W, Hernandez, L E, Nelson, R A, Marsh, K C, Cox, B F, Mittelstadt, S W
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008; Nature Publishing; Nature Publishing Group
• Subjects: Administration, Oral; Adrenergic beta-Antagonists - administration & dosage; Adrenergic beta-Antagonists - pharmacokinetics; Adrenergic beta-Antagonists - toxicity; Animals; arterial blood pressure; Biological and medical sciences; Blood Pressure - drug effects; body temperature; Body Temperature - drug effects; Cardiac dysrhythmias; Cardiology. Vascular system; cardiovascular; Cynomolgus; Dose-Response Relationship, Drug; electrocardiogram; Electrocardiography; Heart; heart rate; Heart Rate - drug effects; Macaca fascicularis; Male; Medical sciences; Models, Animal; monkey; Pharmacology. Drug treatments; Primates; QT prolongation; Research Papers; safety pharmacology; sotalol; Sotalol - administration & dosage; Sotalol - pharmacokinetics; Sotalol - toxicity; Species Specificity; telemetry; Telemetry - methods; Arrhythmia; Toxicity; Monkey; Cardiovascular disease; β-Adrenergic receptor; Dose activity relation; electrocardiogram; arterial blood pressure; Heart block; Heart disease; Primates; Electrocardiography; Arterial pressure; safety pharmacology; Antagonist; Safety; Sotalol; Body temperature; Prolonged QT interval; Antiarrhythmic agent; cardiovascular; Conduction disorder; Heart rate; Vertebrata; Mammalia; QT prolongation; Sulfonamides; Animal; telemetry; Hemodynamics; Circulatory system; Beta blocking agent

Background and purpose: The non‐selective β‐adrenoceptor antagonist, D,L‐sotalol (sotalol) is commonly employed as a positive control during preclinical cardiovascular safety pharmacology testing, mainly because of its ability to prolong QT interval duration. However, no information appears in the l...