The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like eff...
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Published in | Nutrition reviews Vol. 67; no. 7; pp. 398 - 415 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.07.2009
Wiley Oxford University Press |
Subjects | |
Online Access | Get full text |
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Abstract | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like effects of natural isoflavones and possible promotion or propagation of estrogen‐sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case‐control study and meta‐analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. |
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AbstractList | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. [PUBLICATION ABSTRACT] |
Author | Burnett, Bruce P Levy, Robert M Taylor, Christopher K Elliott, Jay C |
Author_xml | – sequence: 1 givenname: Christopher K surname: Taylor fullname: Taylor, Christopher K organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 2 givenname: Robert M surname: Levy fullname: Levy, Robert M organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 3 givenname: Jay C surname: Elliott fullname: Elliott, Jay C organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 4 givenname: Bruce P surname: Burnett fullname: Burnett, Bruce P email: bburnett@primusrx.com organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA |
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SubjectTerms | Animals Anticarcinogenic Agents - pharmacology Biological and medical sciences Breast cancer cancer risk Clinical Trials as Topic Dietary supplements Effects Epidemiologic Studies Epidemiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology genistein Genistein - pharmacology Humans Isoflavones - pharmacology Meta-analysis Mice Neoplasms - prevention & control osteoporosis postmenopausal Prostate cancer Rats Risk factors Soybean Proteins - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
Title | The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies |
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