The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like eff...
Saved in:
| Published in | Nutrition reviews Vol. 67; no. 7; pp. 398 - 415 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.07.2009
Wiley Oxford University Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like effects of natural isoflavones and possible promotion or propagation of estrogen‐sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case‐control study and meta‐analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. |
|---|---|
| AbstractList | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen-like effects of natural isoflavones and possible promotion or propagation of estrogen-sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case-control study and meta-analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. [PUBLICATION ABSTRACT] |
| Author | Burnett, Bruce P Levy, Robert M Taylor, Christopher K Elliott, Jay C |
| Author_xml | – sequence: 1 givenname: Christopher K surname: Taylor fullname: Taylor, Christopher K organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 2 givenname: Robert M surname: Levy fullname: Levy, Robert M organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 3 givenname: Jay C surname: Elliott fullname: Elliott, Jay C organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA – sequence: 4 givenname: Bruce P surname: Burnett fullname: Burnett, Bruce P email: bburnett@primusrx.com organization: Primus Pharmaceuticals, Inc., Scottsdale, Arizona, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21708199$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19566600$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkUtv1DAUhS1URKeFv4AsJFg1wa_YMVIXqOoDMSoCtarExvIkN8XTjDPYk3bm3-OQMEis8MbX9vmur845Qge-84AQpiSnab1f5lQVPBNlqXJGiM4JYZTn22dotn84QLN0qzMpBT9ERzEuCSGUaf4CHVJdSCkJmaF48wMwNA1UG9w1-B68ixtwHtv7dlelX3HncWV9BQFbX_8pg4sPH7DFAR4dPA1kQh7dJnQneB2gap13lW1PRmY64bjpawfxJXre2DbCq2k_RrcX5zdnV9n8y-Wns4_zrCpUybNGgFUNJyBqpbVkSqiag11IYgWlRc3pgjNe0KLUtRWakUpILWrBtORWN5Qfo3dj33XofvYQN2blYgVtaz10fTRSCV5qRZLwzT_CZdcHn2YzjDLONGNDt3IUVaGLMUBj1sGtbNgZSsyQilmawXwzmG-GVMzvVMw2oa-n_v1iBfVfcIohCd5OAhuTUU1ILru41zGqSEm1TrrTUffkWtj99wDm-vbbeaoSn438EPJ2z9vwkMzgqjB315eG3c2_X9Cvn80V_wXJe7eC |
| CODEN | NUREA8 |
| CitedBy_id | crossref_primary_10_1016_j_heliyon_2020_e04228 crossref_primary_10_1080_01635581_2015_989372 crossref_primary_10_2174_1566524023666221128162753 crossref_primary_10_1016_j_intimp_2013_11_016 crossref_primary_10_1111_j_1439_0523_2012_01957_x crossref_primary_10_1124_pr_115_010843 crossref_primary_10_1155_2021_5537917 crossref_primary_10_1016_j_toxlet_2015_12_009 crossref_primary_10_1155_2018_4159013 crossref_primary_10_1186_1475_2867_13_63 crossref_primary_10_1016_j_phymed_2010_03_024 crossref_primary_10_1016_j_taap_2016_05_004 crossref_primary_10_1158_1940_6207_CAPR_15_0417 crossref_primary_10_1002_mnfr_201200439 crossref_primary_10_1007_s11094_020_02298_5 crossref_primary_10_2135_cropsci2012_05_0267 crossref_primary_10_3945_ajcn_112_035972 crossref_primary_10_1080_10408390903579029 crossref_primary_10_1007_s10549_010_1270_8 crossref_primary_10_1093_aje_kws168 crossref_primary_10_1016_j_jnutbio_2016_11_012 crossref_primary_10_1021_acs_jafc_0c03286 crossref_primary_10_1016_j_canlet_2018_06_034 crossref_primary_10_1016_j_etp_2010_10_006 crossref_primary_10_1080_01635581_2011_606955 crossref_primary_10_1002_mnfr_201000415 crossref_primary_10_1007_s12668_023_01201_2 crossref_primary_10_1007_s00204_016_1674_2 crossref_primary_10_1080_21691401_2022_2118758 crossref_primary_10_3390_ijms15021962 crossref_primary_10_1002_ijc_30117 crossref_primary_10_4155_tde_10_29 crossref_primary_10_51847_CZ6T8kG5lr crossref_primary_10_1007_s10552_015_0534_3 crossref_primary_10_7314_APJCP_2012_13_2_479 crossref_primary_10_1134_S1990750811030164 crossref_primary_10_3390_jcm9092846 crossref_primary_10_1002_cncr_29981 crossref_primary_10_1016_S2225_4110_16_30082_7 crossref_primary_10_3390_ijms18061178 crossref_primary_10_1007_s00198_012_2214_4 crossref_primary_10_3390_antiox11020413 crossref_primary_10_1002_ptr_6587 crossref_primary_10_1007_s11095_010_0051_8 crossref_primary_10_1016_j_ctarc_2021_100350 crossref_primary_10_3109_10408444_2010_541900 crossref_primary_10_1016_j_tjnut_2023_03_011 crossref_primary_10_1158_1940_6207_CAPR_10_0329 crossref_primary_10_5625_lar_2014_30_4_143 crossref_primary_10_3390_cancers14246163 crossref_primary_10_3390_ijms13010056 crossref_primary_10_3390_medicines4020018 crossref_primary_10_1177_1559827620913263 crossref_primary_10_1016_j_semcancer_2015_03_006 crossref_primary_10_3945_cdn_117_002063 crossref_primary_10_3390_cancers13215329 crossref_primary_10_1371_journal_pone_0250599 crossref_primary_10_1200_JCO_2012_43_0942 crossref_primary_10_1016_j_biotechadv_2018_12_001 crossref_primary_10_7314_APJCP_2013_14_4_2407 crossref_primary_10_1186_s11671_017_2253_z crossref_primary_10_1016_j_jpba_2020_113216 crossref_primary_10_3945_ajcn_110_008359 crossref_primary_10_1016_j_fct_2015_07_011 crossref_primary_10_3892_ijo_2013_1946 crossref_primary_10_1111_jfpp_14605 crossref_primary_10_1007_s12026_012_8331_5 crossref_primary_10_1016_S1283_081X_20_43722_1 crossref_primary_10_1007_s12609_016_0218_3 crossref_primary_10_1248_bpb_34_1448 crossref_primary_10_1007_s10681_011_0401_6 crossref_primary_10_1134_S1990750811020181 crossref_primary_10_1016_j_maturitas_2009_10_017 crossref_primary_10_3390_nu11112669 crossref_primary_10_1016_j_jnutbio_2022_109250 crossref_primary_10_1080_13697137_2020_1863356 crossref_primary_10_1159_000519784 crossref_primary_10_2131_jts_40_235 crossref_primary_10_4103_0022_3859_93257 crossref_primary_10_1002_mc_20822 crossref_primary_10_1016_j_soncn_2011_11_008 crossref_primary_10_1111_j_1476_5381_2011_01619_x crossref_primary_10_1089_jmf_2013_0067 crossref_primary_10_4236_abc_2013_33040 crossref_primary_10_1016_j_fm_2022_104186 crossref_primary_10_18097_pbmc20125802160 crossref_primary_10_1007_s11356_021_12629_y crossref_primary_10_1007_s12272_015_0561_3 crossref_primary_10_1080_01635581_2016_1115104 crossref_primary_10_18097_pbmc20125803257 crossref_primary_10_1007_s13765_013_3164_z crossref_primary_10_1007_s00232_013_9531_1 crossref_primary_10_1080_07315724_2013_866527 crossref_primary_10_1038_s41598_019_46817_1 crossref_primary_10_1080_10408398_2019_1689097 crossref_primary_10_1007_s10068_017_0111_5 crossref_primary_10_3390_antibiotics12020407 crossref_primary_10_1016_j_bbadis_2018_08_039 crossref_primary_10_1097_MNH_0b013e3283477a7b crossref_primary_10_3109_19390211_2011_571656 crossref_primary_10_1016_S2221_1691_12_60489_4 crossref_primary_10_1016_j_ejphar_2011_06_024 crossref_primary_10_1016_j_phyplu_2021_100138 crossref_primary_10_1097_CAD_0000000000000044 crossref_primary_10_3892_or_2013_2893 crossref_primary_10_1016_j_chemphys_2018_09_003 crossref_primary_10_1111_bph_13622 crossref_primary_10_1016_j_canlet_2012_03_037 crossref_primary_10_1158_1940_6207_CAPR_12_0050 crossref_primary_10_1186_1741_7015_9_98 crossref_primary_10_1016_j_tox_2011_07_005 crossref_primary_10_1007_s11248_013_9777_5 crossref_primary_10_3390_ijms160511728 crossref_primary_10_1016_j_yfrne_2010_03_003 crossref_primary_10_1017_S0029665111003272 crossref_primary_10_3389_fsurg_2019_00041 crossref_primary_10_1007_s00299_011_1052_8 crossref_primary_10_1093_ajcn_nqab358 crossref_primary_10_1080_01635581_2017_1367934 crossref_primary_10_2903_sp_efsa_2015_EN_877 crossref_primary_10_3390_nu6104218 crossref_primary_10_1016_j_critrevonc_2017_09_004 crossref_primary_10_3390_molecules15032000 crossref_primary_10_3390_ijms17071177 crossref_primary_10_3945_jn_111_146498 crossref_primary_10_1016_j_jff_2018_06_026 crossref_primary_10_1155_2022_1263544 crossref_primary_10_1158_1055_9965_EPI_10_1041 crossref_primary_10_1155_2015_587983 |
| Cites_doi | 10.1210/jc.2003-032067 10.1038/sj.onc.1206583 10.1301/nr.2003.janr.1-33 10.1093/jnci/51.5.1409 10.1095/biolreprod.106.052142 10.1016/j.fct.2005.06.004 10.1016/0014-5793(96)00782-X 10.1016/j.canlet.2008.03.052 10.1002/jbmr.5650110615 10.1016/j.cellbi.2008.04.004 10.1089/154099903322404276 10.1016/0304-3835(95)03877-Y 10.1158/0008-5472.CAN-04-4604 10.1038/39645 10.1002/ijc.21863 10.1073/pnas.81.20.6344 10.1016/j.toxlet.2004.04.005 10.1016/S0021-9258(18)45614-1 10.1210/jc.2004-1428 10.1016/S0959-8049(00)00300-2 10.1079/BJN20051640 10.1126/science.3753802 10.1111/j.1349-7006.2000.tb00928.x 10.1079/BJN20031075 10.1016/S0021-9258(19)43566-7 10.1210/en.2006-0563 10.1210/jc.2008-1087 10.1021/jf034427b 10.1093/carcin/bgm004 10.1016/S0021-9258(18)83541-4 10.1210/endo.138.11.5496 10.1111/j.0001-6349.2005.00661.x 10.1016/S0008-6363(01)00526-0 10.1210/endo.138.3.4979 10.1038/320134a0 10.1359/jbmr.2002.17.10.1904 10.1074/jbc.M100953200 10.1016/j.fct.2005.05.021 10.1093/emboj/18.17.4608 10.1042/BST0340633 10.1124/mol.54.1.105 10.1016/j.str.2004.09.015 10.1158/0008-5472.CAN-05-2067 10.1074/jbc.M513684200 10.1007/s00428-003-0947-3 10.1016/j.fct.2005.02.017 10.1128/MCB.24.13.5900-5913.2004 10.1093/jn/134.11.3089 10.1093/jnci/djj102 10.1097/00075197-200411000-00010 10.1158/0008-5472.CAN-04-4109 10.1016/j.fertnstert.2005.08.059 10.1073/pnas.93.12.5925 10.1016/S0304-3835(98)00130-X 10.1210/endo.139.10.6216 10.1097/00006676-200405000-00020 10.1097/00042192-200512020-00013 10.1002/bdrb.20087 10.1089/jmf.2005.8.469 10.1016/j.ijgo.2005.05.005 10.1207/s15327914nc5501_1 10.1006/bbrc.1998.9751 10.1007/s10549-006-9392-8 10.1200/JCO.2006.06.0244 10.1097/01.GME.0000109314.11228.E5 10.1073/pnas.0308319100 10.1128/MCB.24.17.7681-7694.2004 10.1186/1755-8794-1-49 10.1093/carcin/bgg198 10.1097/00008469-200304000-00011 10.1093/jnci/90.13.967 10.1080/01635589309514265 10.1097/01.gme.0000248708.60698.98 10.1002/ijc.11046 10.1016/j.ejphar.2008.04.049 10.1146/annurev.bi.63.070194.002315 10.1093/jnci/djj356 10.1207/s15327914nc4901_8 10.1677/joe.0.1630379 10.1210/endo.138.11.5652 10.1186/bcr1995 10.1038/sj.bjc.6602935 10.1093/jn/130.7.1665 10.1207/s15327914nc5602_2 10.1210/jc.2003-031631 10.1172/JCI27987 10.1002/cncr.21731 10.1093/oxfordjournals.epirev.a036102 10.1158/0008-5472.879.65.3 10.7326/0003-4819-146-12-200706190-00005 10.1002/ijc.2910290602 10.1210/edrv-17-6-587 10.1093/ajcn/78.3.593S 10.1016/S0006-291X(88)80030-5 10.1080/01635581.2001.9680615 10.1016/j.ejphar.2008.04.041 10.1093/jnci/85.22.1819 10.1200/JCO.2002.20.6.1449 10.1093/ajcn/71.6.1705S 10.1158/0008-5472.CAN-03-2446 10.1093/jn/131.4.1362S 10.1055/s-2005-864186 10.1248/bpb.27.185 10.1158/1078-0432.925s.11.2 10.1093/jn/131.11.2957 10.1124/pr.58.4.8 10.1002/mc.20300 10.1093/ajcn/68.6.1431S 10.1007/s10549-006-9191-2 10.1023/A:1015722507237 10.1093/jn/132.12.3577 10.1359/jbmr.080201 10.1200/JCO.2007.13.9964 10.1016/0165-1218(80)90036-1 10.1093/carcin/16.11.2833 10.1016/S0304-3835(98)00141-4 10.1093/carcin/bgi370 |
| ContentType | Journal Article |
| Copyright | 2009 International Life Sciences Institute 2009 INIST-CNRS Copyright International Life Sciences Institute Jul 2009 |
| Copyright_xml | – notice: 2009 International Life Sciences Institute – notice: 2009 INIST-CNRS – notice: Copyright International Life Sciences Institute Jul 2009 |
| DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION K9. NAPCQ 7X8 |
| DOI | 10.1111/j.1753-4887.2009.00213.x |
| DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Economics Diet & Clinical Nutrition |
| EISSN | 1753-4887 |
| EndPage | 415 |
| ExternalDocumentID | 1769573151 10_1111_j_1753_4887_2009_00213_x 19566600 21708199 NURE213 ark_67375_WNG_2WLZF1QK_H |
| Genre | article Journal Article Review |
| GeographicLocations | United States--US |
| GeographicLocations_xml | – name: United States--US |
| GroupedDBID | --- -ET -~X .3N .55 .GA .GJ .Y3 05W 0R~ 10A 123 186 1OC 1TH 29N 31~ 36B 3EH 3O- 3V. 4.4 48X 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52W 52X 53G 5HH 5LA 5RE 5VS 5WD 6PF 702 7PT 7RV 7X2 7X7 8-0 8-1 8-3 8-4 8-5 85S 88E 88I 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 8UM 930 A01 A03 AABJS AABMN AABZA AACZT AAESY AAHHS AAIYJ AAJQQ AAMDB AAMVS AAOGV AAONW AAPGJ AAPQZ AAPXW AAUQX AAVAP AAWDT AAWTL AAYOK ABEUO ABFSI ABIXL ABJNI ABOCM ABPQP ABPTD ABPTK ABQLI ABSAR ABSMQ ABUWG ABWST ACBNA ACBWZ ACCFJ ACFRR ACGFO ACGFS ACGOD ACIMA ACKIV ACUFI ACUTJ ACXME ACXQS ADBBV ADEIU ADEZT ADGZP ADHKW ADHZD ADIPN ADIZJ ADJQC ADORX ADQLU ADRIX ADRTK ADVEK ADYVW AEEZP AEGPL AEGXH AEHKS AEIMD AEJOX AEKSI AEMDU AENEX AENZO AEPUE AEQDE AEQTP AETBJ AEWNT AFBPY AFDAS AFFDN AFFZL AFIYH AFKRA AFOFC AFRAH AFXEN AFYAG AFZJQ AGINJ AGQXC AGSYK AHEFC AHMBA AIAGR AIKOY AIMBJ AIWBW AJAOE AJBDE AJEEA AKWXX ALEEW ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX AMBMR APIBT APJGH AQDSO AQKUS ASMCH ASPBG ATCPS AVWKF AWCFO AXUDD AZBYB AZFZN AZQEC AZQFJ BAFTC BAYMD BCR BCRHZ BCU BDRZF BEC BENPR BEYMZ BFHJK BHONS BHPHI BKEYQ BKNYI BKOMP BLC BPHCQ BSCLL BTRTY BVRKM BVXVI BY8 BYORX BZKNY C45 CAG CASEJ CCPQU CDBKE COF CS3 D-6 D-7 D-E D-F DAKXR DCZOG DILTD DPPUQ DPXWK DU5 DWQXO EBS EHX EIHJH EJD EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FLUFQ FOEOM FOTVD FQBLK FYUFA G-S G.N GAUVT GJXCC GNUQQ GODZA GUQSH H.X HAR HCIFZ HF~ HMCUK HOLLA HVGLF HZ~ IH2 J0M J21 K9- KBUDW KOP KSI KSN L7B LC2 LC3 LH4 LP6 LP7 LW6 M0K M0R M1P M2O M2P MBLQV MK4 ML0 MVM N04 N05 N9A NAPCQ NF~ NOMLY NOYVH NVLIB O9- OAWHX OBFPC OCZFY ODMLO OHT OJQWA OJZSN OPAEJ OVD OWPYF P-O P2P P2X P2Z P4B P4D PAFKI PCD PEA PEELM PQQKQ PROAC PSQYO Q.N Q11 Q2X Q5Y QB0 R.K RIG ROL ROX ROZ RUSNO RWL RX1 RXO RXW S0X SDH SJFOW SUPJJ TAE TEORI TJX TMA TOX UAP UB1 UCV UHB UKHRP UKR V8K W8V W99 WH7 WOW WQ9 WRC WYJ WYUIH X7M XFK XG1 XJT XOL Y6R YAYTL YHZ YKOAZ YOC YQI YQJ YROCO YXANX YYQ ZCA ZCG ZGI ZR0 ZXP ~IA ~KM ~WT AAHBH AARHZ AASNB AAUAY ABNHQ ABXVV ACZBC ADQBN ADUKH AGKRT AGMDO ALIPV AVNTJ H13 OIG UIG 08R 33P AAPBV ABFLS ADCFL ADGIM ADMTO AGVJH BBAFP BGYMP IPNFZ IQODW K78 PADUT PQEST PQUKI PRINS ATGXG CGR CUY CVF ECM EIF NPM AAYXX CITATION K9. 7X8 |
| ID | FETCH-LOGICAL-c5783-f4ea7f30e4d79962747d3eab60a4115d31b32351589da4920c4694d42963a9f13 |
| ISSN | 0029-6643 |
| IngestDate | Fri Aug 16 22:14:31 EDT 2024 Thu Oct 10 19:36:26 EDT 2024 Thu Sep 12 18:11:51 EDT 2024 Tue Oct 15 23:38:42 EDT 2024 Fri Nov 25 01:05:09 EST 2022 Sat Aug 24 00:51:43 EDT 2024 Wed Jan 17 05:03:02 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Keywords | Isoflavone Breast disease Genistein Diseases of the osteoarticular system Aglycone Breast cancer Review Malignant tumor In vitro Mammary gland diseases Osteoporosis Symptomatology Vertebrata Mammalia Risk factor Postmenopause cancer risk Cancer postmenopausal |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c5783-f4ea7f30e4d79962747d3eab60a4115d31b32351589da4920c4694d42963a9f13 |
| Notes | istex:85D20B9C79B763812F148B23381624147C6F5551 ark:/67375/WNG-2WLZF1QK-H ArticleID:NURE213 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| OpenAccessLink | https://academic.oup.com/nutritionreviews/article-pdf/67/7/398/24093444/nutritionreviews67-0398.pdf |
| PMID | 19566600 |
| PQID | 212329221 |
| PQPubID | 42187 |
| PageCount | 18 |
| ParticipantIDs | proquest_miscellaneous_67438970 proquest_journals_212329221 crossref_primary_10_1111_j_1753_4887_2009_00213_x pubmed_primary_19566600 pascalfrancis_primary_21708199 wiley_primary_10_1111_j_1753_4887_2009_00213_x_NURE213 istex_primary_ark_67375_WNG_2WLZF1QK_H |
| PublicationCentury | 2000 |
| PublicationDate | July 2009 |
| PublicationDateYYYYMMDD | 2009-07-01 |
| PublicationDate_xml | – month: 07 year: 2009 text: July 2009 |
| PublicationDecade | 2000 |
| PublicationPlace | Malden, USA |
| PublicationPlace_xml | – name: Malden, USA – name: Hoboken, NJ – name: United States – name: Oxford |
| PublicationTitle | Nutrition reviews |
| PublicationTitleAlternate | Nutr Rev |
| PublicationYear | 2009 |
| Publisher | Blackwell Publishing Inc Wiley Oxford University Press |
| Publisher_xml | – name: Blackwell Publishing Inc – name: Wiley – name: Oxford University Press |
| References | Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, Korach KS, et al. International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev. 2006;58:773-781. Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. J Med Food. 2005;8:469-475. Limer JL, Parkes AT, Speirs V. Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro. Int J Cancer. 2006;119:515-521. Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M. Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways. Mol Cell Biol. 2004;24:7681-7694. McClain RM, Wolz E, Davidovich A, Pfannkuch F, Bausch J. Subchronic and chronic safety studies with genistein in dogs. Food Chem Toxicol. 2005;43:1461-1482. Greene GL, Gilna P, Waterfield M, Baker A, Hort Y, Shine J. Sequence and expression of human estrogen receptor complementary DNA. Science. 1986;231:1150-1154. D'Anna R, Baviera G, Corrado F, Cancellieri F, Crisafulli A, Squadrito F. The effect of the phytoestrogen genistein and hormone replacement therapy on homocysteine and C-reactive protein level in postmenopausal women. Acta Obstet Gynecol Scand. 2005;84:474-477. Babiker FA, De Windt LJ, Van Eickels M, Grohe C, Meyer R, Doevendans PA. Estrogenic hormone action in the heart: regulatory network and function. Cardiovasc Res. 2002;53:709-719. Wei H, Wei L, Frenkel K, Bowen R, Barnes S. Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutr Cancer. 1993;20:1-12. Francone OL, Gurakar A, Fielding C. Distribution and functions of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol. J Biol Chem. 1989;264:7066-7072. Barkhem T, Carlsson B, Nilsson Y, Enmark E, Gustafsson J, Nilsson S. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. Mol Pharmacol. 1998;54:105-112. An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem. 2001;276:17808-17814. Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res. 2005;65:6934-6942. Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engstrom O, et al. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist. EMBO J. 1999;18:4608-4618. Vantyghem SA, Wilson SM, Postenka CO, Al-Katib W, Tuck AB, Chambers AF. Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model. Cancer Res. 2005;65:3396-3403. Yue W, Wang JP, Li Y, et al. Tamoxifen versus aromatase inhibitors for breast cancer prevention. Clin Cancer Res. 2005;11(Suppl):S925-S930. Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner. Cancer Res. 2001;61:5045-5050. Van Patten CL, Olivotto IA, Chambers GK, Gelmon KA, Hislop TG, Templeton E, et al. Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol. 2002;20:1449-1455. Seo HS, DeNardo DG, Jacquot Y, Laios I, Vidal DS, Zambrana CR, et al. Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha. Breast Cancer Res Treat. 2006;99:121-134. Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med. 2007;146:839-847. Mohammad RM, Banerjee S, Li Y, Aboukameel A, Kucuk O, Sarkar FH. Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts. Cancer. 2006;106:1260-1268. Regenbrecht CR, Jung M, Lehrach H, Adjaye J. The molecular basis of phytoestrogen genistein induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008;1:49. Banerjee S, Li Y, Wang Z, Sarkar FH. Multi-targeted therapy of cancer by genistein. Cancer Lett. 2008;269:226-242. Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, Van Der Saag PT, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 1998;139:4252-4263. Magee PJ, Rowland IR. Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer. Br J Nutr. 2004;91:513-531. Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, et al. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006;75:477-486. Maskarinec G, Williams AE, Inouye JS, Stanczyk FZ, Franke AA. A randomized isoflavone intervention among premenopausal women. Cancer Epidemiol Biomarkers Prev. 2002;11:195-201. Kostelac D, Rechkemmer G, Briviba K. Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element. J Agric Food Chem. 2003;51:7632-7635. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS. Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology. 1997;138:4613-4621. Ward H, Chapelais G, Kuhnle GGC, Luben R, Khaw KT, Bingham S. Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study. Breast Cancer Res. 2008;10:R32. Marini H, Bitto A, Altavilla D, Burnett B, Polito F, Minutoli L, et al. Breast safety and efficacy of genistein aglycone for post-menopausal bone loss: a follow-up study. J Clin Endocrinol Metab. 2008;93:4787-4796. Lamartiniere CA. Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr. 2000;71(Suppl):S1705-S1707; discussion S1708-S1709. Cho KH, Pezzuto JM, Bolton JL, Steele VE, Kelloff GJ, Lee SK, et al. Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity. Eur J Cancer. 2000;36:2146-2156. Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J Nutr. 2001;131:2957-2962. Fioravanti L, Cappelletti V, Miodini P, Ronchi E, Brivio M, Di Fronzo G. Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett. 1998;130:143-152. Wood CE, Register TC, Franke AA, Anthony MS, Cline JM. Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast. Cancer Res. 2006;66:1241-1249. Le Bail JC, Varnat F, Nicolas JC, Habrioux G. Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett. 1998;130:209-216. Satoh H, Nishikawa K, Suzuki K, Asano R, Virgona N, Ichikawa T, et al. Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent. Res Commun Mol Pathol Pharmacol. 2003;113-114:149-158. Jakes RW, Duffy SW, Ng FC, Gao F, Ng EH, Seow A, et al. Mammographic parenchymal patterns and self-reported soy intake in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 2002;11:608-613. Deroo BJ, Kenneth S, Korach KS. Estrogen receptors and human disease. J Clin Invest. 2006;116:561-570. Crisafulli A, Altavilla D, Marini H, Bitto A, Cucinotta D, Frisina N, et al. Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause. 2005;12:186-192. Bartholomew RM, Ryan DS. Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay. Mutat Res. 1980;78:317-321. Constantinou AI, Lantvit D, Hawthorne M, Xu X, Van Breemen RB, Pezzuto JM. Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats. Nutr Cancer. 2001;41:75-81. Arts J, Kuiper GG, Janssen JM, Gustafsson JA, Lowik CW, Pols HA, et al. Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells. Endocrinology. 1997;138:5067-5070. Ursin G, Sun CL, Koh WP, Khoo KS, Gao F, Wu AH, et al. Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Nutr Cancer. 2006;56:128-135. Santell RC, Kieu N, Helferich WG. Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice. J Nutr. 2000;130:1665-1669. Gong L, Li Y, Nedeljkovic-Kurepa A, Sarkar FH. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells. Oncogene. 2003;22:4702-4709. Mosselman S, Polman J, Dijkema R. ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett. 1996;392:49-53. Teede HJ, Dalais FS, Kotsopoulos D, McGrath BP, Malan E, Gan TE, et al. Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women. J Clin Endocrinol Metab. 2005;90:1936-1941. Michael McClain R, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J. Acute, subchronic and chronic safety studies with genistein in rats. Food Chem Toxicol. 2006;44:56-80. Liu Y, Zhang YM, Song DF 2002; 17 2007; 104 2004; 444 2006; 34 2004; 27 2004; 28 2004; 25 2004; 7 2000; 85 1993; 20 2004; 24 2002; 11 1999; 163 2005; 65 2000; 130 2008; 32 2008; 589 2000; 91 2008; 588 1998; 83 1989; 49 2003; 51 1994; 63 2007; 79 2001; 41 1997; 389 2001; 61 2001; 131 2006; 27 1997; 57 2008; 26 2008; 23 1998; 90 2005; 71 2006; 281 1996; 17 2006; 119 1973; 248 1986; 231 2006; 56 2002; 132 2004; 49 2006; 55 2005; 90 2006; 58 2002; 7 2005; 84 1996; 93 2000; 71 1998; 139 2006; 116 1998; 253 1996; 16 2007; 14 1996; 11 1998; 130 1998; 68 2001; 276 2003; 105 2006; 44 2002; 62 2004; 151 2005; 8 1988; 157 2005; 10 1998; 7 1998; 5 2006; 106 2003; 101 2005; 11 2005; 12 2003; 22 1993; 7 1987; 262 2007; 146 2004; 64 1973; 51 2006; 75 2002; 53 2006; 77 2008; 269 1999; 84 2005; 26 2008; 1 2003; 113 2001; 86 2003; 12 2007; 28 2004; 134 1982; 29 1999; 18 2006; 66 1980; 78 1989; 264 2000; 60 1998; 54 2005; 34 2007; 25 1998; 58 2004; 101 1995; 95 1997; 138 2006; 94 1984; 81 2006; 95 1995; 16 2006; 98 2006; 99 2006; 16 2004; 89 1993; 85 2005; 43 2008; 10 2004; 91 2008; 93 2003; 78 1993; 15 2004; 11 2006; 85 2000; 36 2002; 20 1986; 320 2004; 12 1996; 392 2003; 61 2007; 46 2006; 147 Satoh (10.1111/j.1753-4887.2009.00213.x-BIB73) 2003; 113 Okura (10.1111/j.1753-4887.2009.00213.x-BIB81) 1988; 157 Tham (10.1111/j.1753-4887.2009.00213.x-BIB134) 1998; 83 10.1111/j.1753-4887.2009.00213.x-BIB61 Messina (10.1111/j.1753-4887.2009.00213.x-BIB96) 2006; 98 Setchell (10.1111/j.1753-4887.2009.00213.x-BIB52) 2001; 131 10.1111/j.1753-4887.2009.00213.x-BIB60 Rae (10.1111/j.1753-4887.2009.00213.x-BIB105) 2007; 104 Ullmann (10.1111/j.1753-4887.2009.00213.x-BIB53) 2005; 71 Wood (10.1111/j.1753-4887.2009.00213.x-BIB106) 2004; 89 Vantyghem (10.1111/j.1753-4887.2009.00213.x-BIB104) 2005; 65 Bartholomew (10.1111/j.1753-4887.2009.00213.x-BIB133) 1980; 78 An (10.1111/j.1753-4887.2009.00213.x-BIB47) 2001; 276 Gong (10.1111/j.1753-4887.2009.00213.x-BIB77) 2003; 22 Michael McClain (10.1111/j.1753-4887.2009.00213.x-BIB130) 2006; 44 Deroo (10.1111/j.1753-4887.2009.00213.x-BIB14) 2006; 116 Nagel (10.1111/j.1753-4887.2009.00213.x-BIB140) 2005; 10 Lu (10.1111/j.1753-4887.2009.00213.x-BIB120) 2000; 60 Crisafulli (10.1111/j.1753-4887.2009.00213.x-BIB35) 2005; 12 Jeune (10.1111/j.1753-4887.2009.00213.x-BIB67) 2005; 8 Akiyama (10.1111/j.1753-4887.2009.00213.x-BIB80) 1987; 262 Lamartiniere (10.1111/j.1753-4887.2009.00213.x-BIB101) 2000; 71 Liu (10.1111/j.1753-4887.2009.00213.x-BIB89) 2005; 65 Lu (10.1111/j.1753-4887.2009.00213.x-BIB119) 2000; 60 Deroo (10.1111/j.1753-4887.2009.00213.x-BIB27) 2006; 116 Banerjee (10.1111/j.1753-4887.2009.00213.x-BIB85) 2008; 269 Regenbrecht (10.1111/j.1753-4887.2009.00213.x-BIB79) 2008; 1 Setchell (10.1111/j.1753-4887.2009.00213.x-BIB145) 2003; 78 Fan (10.1111/j.1753-4887.2009.00213.x-BIB86) 2006; 94 Maskarinec (10.1111/j.1753-4887.2009.00213.x-BIB117) 2002; 11 Levenson (10.1111/j.1753-4887.2009.00213.x-BIB103) 1997; 57 Cho (10.1111/j.1753-4887.2009.00213.x-BIB82) 2000; 36 Trock (10.1111/j.1753-4887.2009.00213.x-BIB3) 2006; 98 Kousidou (10.1111/j.1753-4887.2009.00213.x-BIB78) 2005; 26 Upadhyaya (10.1111/j.1753-4887.2009.00213.x-BIB97) 1998; 5 Messina (10.1111/j.1753-4887.2009.00213.x-BIB4) 2004; 7 Duffy (10.1111/j.1753-4887.2009.00213.x-BIB128) 2003; 12 Messina (10.1111/j.1753-4887.2009.00213.x-BIB5) 2006; 55 Dahlman-Wright (10.1111/j.1753-4887.2009.00213.x-BIB13) 2006; 58 Mohammad (10.1111/j.1753-4887.2009.00213.x-BIB75) 2006; 106 Chu (10.1111/j.1753-4887.2009.00213.x-BIB50) 2000; 85 Iwasaki (10.1111/j.1753-4887.2009.00213.x-BIB138) 2008; 26 Michael McClain (10.1111/j.1753-4887.2009.00213.x-BIB56) 2006; 44 Nikander (10.1111/j.1753-4887.2009.00213.x-BIB131) 2003; 101 Paruthiyil (10.1111/j.1753-4887.2009.00213.x-BIB39) 2004; 64 Soule (10.1111/j.1753-4887.2009.00213.x-BIB63) 1973; 51 Ziegler (10.1111/j.1753-4887.2009.00213.x-BIB135) 1993; 85 Kostelac (10.1111/j.1753-4887.2009.00213.x-BIB38) 2003; 51 Pike (10.1111/j.1753-4887.2009.00213.x-BIB37) 1999; 18 Manas (10.1111/j.1753-4887.2009.00213.x-BIB43) 2004; 12 Yue (10.1111/j.1753-4887.2009.00213.x-BIB48) 2005; 11 Farina (10.1111/j.1753-4887.2009.00213.x-BIB69) 2006; 16 Morabito (10.1111/j.1753-4887.2009.00213.x-BIB8) 2002; 17 Lax (10.1111/j.1753-4887.2009.00213.x-BIB49) 2004; 444 Allred (10.1111/j.1753-4887.2009.00213.x-BIB94) 2004; 25 Harris (10.1111/j.1753-4887.2009.00213.x-BIB102) 2004; 89 Allred (10.1111/j.1753-4887.2009.00213.x-BIB7) 2001; 61 Kuiper (10.1111/j.1753-4887.2009.00213.x-BIB18) 1996; 93 Le Bail (10.1111/j.1753-4887.2009.00213.x-BIB65) 1998; 130 Boulton (10.1111/j.1753-4887.2009.00213.x-BIB113) 2006; 34 Wood (10.1111/j.1753-4887.2009.00213.x-BIB108) 2006; 66 Francone (10.1111/j.1753-4887.2009.00213.x-BIB125) 1989; 264 Limer (10.1111/j.1753-4887.2009.00213.x-BIB92) 2006; 119 Ju (10.1111/j.1753-4887.2009.00213.x-BIB111) 2006; 27 Hsieh (10.1111/j.1753-4887.2009.00213.x-BIB30) 2006; 281 Barkhem (10.1111/j.1753-4887.2009.00213.x-BIB31) 1998; 54 Greene (10.1111/j.1753-4887.2009.00213.x-BIB16) 1986; 231 Pike (10.1111/j.1753-4887.2009.00213.x-BIB118) 1993; 15 Kuiper (10.1111/j.1753-4887.2009.00213.x-BIB28) 1997; 138 Liu (10.1111/j.1753-4887.2009.00213.x-BIB68) 2005; 34 Kinjo (10.1111/j.1753-4887.2009.00213.x-BIB90) 2004; 27 Brzozowski (10.1111/j.1753-4887.2009.00213.x-BIB42) 1997; 389 Caetano (10.1111/j.1753-4887.2009.00213.x-BIB87) 2006; 95 Santell (10.1111/j.1753-4887.2009.00213.x-BIB93) 2000; 130 Strom (10.1111/j.1753-4887.2009.00213.x-BIB40) 2004; 101 Li (10.1111/j.1753-4887.2009.00213.x-BIB19) 2004; 24 Crisafulli (10.1111/j.1753-4887.2009.00213.x-BIB12) 2004; 11 Yaghmaie (10.1111/j.1753-4887.2009.00213.x-BIB21) 2005; 26 Lamartiniere (10.1111/j.1753-4887.2009.00213.x-BIB99) 2002; 7 Rajah (10.1111/j.1753-4887.2009.00213.x-BIB124) 1996; 16 Tsutsui (10.1111/j.1753-4887.2009.00213.x-BIB51) 2003; 105 Severson (10.1111/j.1753-4887.2009.00213.x-BIB137) 1989; 49 Rozman (10.1111/j.1753-4887.2009.00213.x-BIB57) 2006; 77 Kuiper (10.1111/j.1753-4887.2009.00213.x-BIB29) 1998; 139 Schwartz (10.1111/j.1753-4887.2009.00213.x-BIB91) 1998; 253 Lu (10.1111/j.1753-4887.2009.00213.x-BIB121) 2001; 86 Mai (10.1111/j.1753-4887.2009.00213.x-BIB70) 2007; 28 Giri (10.1111/j.1753-4887.2009.00213.x-BIB58) 1995; 95 Mai (10.1111/j.1753-4887.2009.00213.x-BIB72) 2007; 46 Maskarinec (10.1111/j.1753-4887.2009.00213.x-BIB116) 2003; 12 Razandi (10.1111/j.1753-4887.2009.00213.x-BIB112) 2004; 24 Magee (10.1111/j.1753-4887.2009.00213.x-BIB1) 2004; 91 D'Anna (10.1111/j.1753-4887.2009.00213.x-BIB34) 2005; 84 Gustafsson (10.1111/j.1753-4887.2009.00213.x-BIB45) 1999; 163 Constantinou (10.1111/j.1753-4887.2009.00213.x-BIB100) 2001; 41 McMichael-Phillips (10.1111/j.1753-4887.2009.00213.x-BIB127) 1998; 68 Tsai (10.1111/j.1753-4887.2009.00213.x-BIB25) 1994; 63 Ursin (10.1111/j.1753-4887.2009.00213.x-BIB142) 2006; 56 Li (10.1111/j.1753-4887.2009.00213.x-BIB74) 2005; 65 Marini (10.1111/j.1753-4887.2009.00213.x-BIB10) 2008; 23 Fioravanti (10.1111/j.1753-4887.2009.00213.x-BIB64) 1998; 130 Yildiz (10.1111/j.1753-4887.2009.00213.x-BIB33) 2005; 90 Choi (10.1111/j.1753-4887.2009.00213.x-BIB83) 2000; 91 Babiker (10.1111/j.1753-4887.2009.00213.x-BIB23) 2002; 53 Maskarinec (10.1111/j.1753-4887.2009.00213.x-BIB115) 2004; 134 Hargreaves (10.1111/j.1753-4887.2009.00213.x-BIB122) 1999; 84 D'Anna (10.1111/j.1753-4887.2009.00213.x-BIB11) 2007; 14 Jakes (10.1111/j.1753-4887.2009.00213.x-BIB141) 2002; 11 Jordan (10.1111/j.1753-4887.2009.00213.x-BIB46) 1998; 90 Yatani (10.1111/j.1753-4887.2009.00213.x-BIB136) 1982; 29 Ju (10.1111/j.1753-4887.2009.00213.x-BIB95) 2001; 131 Marini (10.1111/j.1753-4887.2009.00213.x-BIB36) 2008; 93 Mosselman (10.1111/j.1753-4887.2009.00213.x-BIB17) 1996; 392 Atteritano (10.1111/j.1753-4887.2009.00213.x-BIB114) 2008; 589 Di Virgilio (10.1111/j.1753-4887.2009.00213.x-BIB55) 2004; 151 Rucinska (10.1111/j.1753-4887.2009.00213.x-BIB62) 2008; 32 Wood (10.1111/j.1753-4887.2009.00213.x-BIB107) 2006; 85 Ward (10.1111/j.1753-4887.2009.00213.x-BIB146) 2008; 10 Lamartiniere (10.1111/j.1753-4887.2009.00213.x-BIB98) 1995; 16 Beekman (10.1111/j.1753-4887.2009.00213.x-BIB24) 1993; 7 Van Patten (10.1111/j.1753-4887.2009.00213.x-BIB132) 2002; 20 Teede (10.1111/j.1753-4887.2009.00213.x-BIB32) 2005; 90 Beato (10.1111/j.1753-4887.2009.00213.x-BIB26) 1996; 17 Green (10.1111/j.1753-4887.2009.00213.x-BIB15) 1986; 320 Wood (10.1111/j.1753-4887.2009.00213.x-BIB109) 2006; 75 Brown (10.1111/j.1753-4887.2009.00213.x-BIB123) 1984; 81 Ju (10.1111/j.1753-4887.2009.00213.x-BIB110) 2002; 62 Sartippour (10.1111/j.1753-4887.2009.00213.x-BIB129) 2004; 49 Chang (10.1111/j.1753-4887.2009.00213.x-BIB41) 2006; 147 Draper (10.1111/j.1753-4887.2009.00213.x-BIB44) 1996; 11 Thasni (10.1111/j.1753-4887.2009.00213.x-BIB88) 2008; 588 Verheus (10.1111/j.1753-4887.2009.00213.x-BIB139) 2007; 25 Couse (10.1111/j.1753-4887.2009.00213.x-BIB22) 1997; 138 Wei (10.1111/j.1753-4887.2009.00213.x-BIB84) 1993; 20 McClain (10.1111/j.1753-4887.2009.00213.x-BIB54) 2005; 43 Delclos (10.1111/j.1753-4887.2009.00213.x-BIB59) 2007; 79 Li (10.1111/j.1753-4887.2009.00213.x-BIB76) 2004; 28 Setchell (10.1111/j.1753-4887.2009.00213.x-BIB144) 2002; 132 Munro (10.1111/j.1753-4887.2009.00213.x-BIB2) 2003; 61 Valachovicova (10.1111/j.1753-4887.2009.00213.x-BIB71) 2004; 25 Seo (10.1111/j.1753-4887.2009.00213.x-BIB6) 2006; 99 Pearlman (10.1111/j.1753-4887.2009.00213.x-BIB126) 1973; 248 Hsieh (10.1111/j.1753-4887.2009.00213.x-BIB66) 1998; 58 Marini (10.1111/j.1753-4887.2009.00213.x-BIB9) 2007; 146 Boyd (10.1111/j.1753-4887.2009.00213.x-BIB143) 1998; 7 Arts (10.1111/j.1753-4887.2009.00213.x-BIB20) 1997; 138 |
| References_xml | – volume: 130 start-page: 1665 year: 2000 end-page: 1669 article-title: Genistein inhibits growth of estrogen‐independent human breast cancer cells in culture but not in athymic mice publication-title: J Nutr – volume: 320 start-page: 134 year: 1986 end-page: 139 article-title: Human oestrogen receptor cDNA: sequence, expression and homology to v‐erb‐A publication-title: Nature – volume: 116 start-page: 561 year: 2006 end-page: 570 article-title: Estrogen receptors and human disease publication-title: J Clin Invest – volume: 84 start-page: 474 year: 2005 end-page: 477 article-title: The effect of the phytoestrogen genistein and hormone replacement therapy on homocysteine and C‐reactive protein level in postmenopausal women publication-title: Acta Obstet Gynecol Scand – volume: 29 start-page: 611 year: 1982 end-page: 616 article-title: Geographic pathology of latent prostatic carcinoma publication-title: Int J Cancer – volume: 98 start-page: 459 year: 2006 end-page: 471 article-title: Meta‐analysis of soy intake and breast cancer risk publication-title: J Natl Cancer Inst – volume: 22 start-page: 4702 year: 2003 end-page: 4709 article-title: Inactivation of NF‐kappaB by genistein is mediated Akt signaling pathway in breast cancer cells publication-title: Oncogene – volume: 75 start-page: 477 year: 2006 end-page: 486 article-title: Effects of high‐dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys publication-title: Biol Reprod – volume: 55 start-page: 1 year: 2006 end-page: 12 article-title: Estimated Asian adult soy protein and isoflavone intakes publication-title: Nutr Cancer – volume: 281 start-page: 17909 year: 2006 end-page: 17919 article-title: Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity publication-title: J Biol Chem – volume: 106 start-page: 1260 year: 2006 end-page: 1268 article-title: Cisplatin‐induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC‐3 pancreatic tumor xenografts publication-title: Cancer – volume: 589 start-page: 22 year: 2008 end-page: 26 article-title: Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo‐controlled study publication-title: Eur J Pharmacol – volume: 81 start-page: 6344 year: 1984 end-page: 6348 article-title: Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF‐7 publication-title: Proc Natl Acad Sci USA – volume: 17 start-page: 1904 year: 2002 end-page: 1912 article-title: Effects of genistein and hormone‐replacement therapy on bone loss in early postmenopausal women: a randomized double‐blind placebo‐controlled study publication-title: J Bone Miner Res – volume: 24 start-page: 7681 year: 2004 end-page: 7694 article-title: Single‐chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways publication-title: Mol Cell Biol – volume: 51 start-page: 7632 year: 2003 end-page: 7635 article-title: Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element publication-title: J Agric Food Chem – volume: 61 start-page: 1 year: 2003 end-page: 33 article-title: Soy isoflavones: a safety review publication-title: Nutr Rev – volume: 89 start-page: 1779 year: 2004 end-page: 1787 article-title: Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment publication-title: J Clin Endocrinol Metab – volume: 25 start-page: 648 year: 2007 end-page: 655 article-title: Plasma phytoestrogens and subsequent breast cancer risk publication-title: J Clin Oncol – volume: 84 start-page: 4017 year: 1999 end-page: 4024 article-title: Two‐week dietary soy supplementation has an estrogenic effect on normal premenopausal breast publication-title: J Clin Endocrinol Metab – volume: 113 start-page: 149 issue: 114 year: 2003 end-page: 158 article-title: Genistein, a soy isoflavone, enhances necrotic‐like cell death in a breast cancer cell treated with a chemotherapeutic agent publication-title: Res Commun Mol Pathol Pharmacol – volume: 392 start-page: 49 year: 1996 end-page: 53 article-title: ER beta: identification and characterization of a novel human estrogen receptor publication-title: FEBS Lett – volume: 34 start-page: 633 year: 2006 end-page: 645 article-title: Cellular functions of the BRCA tumour‐suppressor proteins publication-title: Biochem Soc Trans – volume: 23 start-page: 715 year: 2008 end-page: 720 article-title: OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2‐year genistein administration publication-title: J Bone Miner Res – volume: 85 start-page: 1200 year: 2000 end-page: 1205 article-title: Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors publication-title: J Clin Endocrinol Metab – volume: 58 start-page: 3833 year: 1998 end-page: 3838 article-title: Estrogenic effects of genistein on the growth of estrogen receptor‐positive human breast cancer (MCF‐7) cells and publication-title: Cancer Res – volume: 14 start-page: 648 year: 2007 end-page: 655 article-title: Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1‐year randomized, double‐blind, placebo‐controlled study publication-title: Menopause – volume: 101 start-page: 1566 year: 2004 end-page: 1571 article-title: Estrogen receptor beta inhibits 17beta‐estradiol‐stimulated proliferation of the breast cancer cell line T47D publication-title: Proc Natl Acad Sci USA – volume: 253 start-page: 38 year: 1998 end-page: 43 article-title: Genistein‐mediated attenuation of tamoxifen‐induced antagonism from estrogen receptor‐regulated genes publication-title: Biochem Biophys Res Commun – volume: 11 start-page: 608 year: 2002 end-page: 613 article-title: Mammographic parenchymal patterns and self‐reported soy intake in Singapore Chinese women publication-title: Cancer Epidemiol Biomarkers Prev – volume: 138 start-page: 863 year: 1997 end-page: 870 article-title: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta publication-title: Endocrinology – volume: 147 start-page: 4831 year: 2006 end-page: 4842 article-title: Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells publication-title: Endocrinology – volume: 151 start-page: 151 year: 2004 end-page: 162 article-title: Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells publication-title: Toxicol Lett – volume: 34 start-page: 67 year: 2005 end-page: 69 article-title: Effect of apoptosis in human breast cancer cells and its probable mechanisms by genistein publication-title: Wei Sheng Yan Jiu – volume: 588 start-page: 158 year: 2008 end-page: 164 article-title: Genistein induces apoptosis in ovarian cancer cells different molecular pathways depending on breast cancer susceptibility gene‐1 (BRCA1) status publication-title: Eur J Pharmacol – volume: 12 start-page: 186 year: 2005 end-page: 192 article-title: Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women publication-title: Menopause – volume: 28 start-page: e90 year: 2004 end-page: 95 article-title: Apoptosis‐inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF‐kappaB in BxPC‐3 pancreatic cancer cell line publication-title: Pancreas – volume: 11 start-page: 195 year: 2002 end-page: 201 article-title: A randomized isoflavone intervention among premenopausal women publication-title: Cancer Epidemiol Biomarkers Prev – volume: 90 start-page: 128 year: 2005 end-page: 133 article-title: Effects of raloxifene, hormone therapy, and soy isoflavone on serum high‐sensitive C‐reactive protein in postmenopausal women publication-title: Int J Gynaecol Obstet – volume: 132 start-page: 3577 year: 2002 end-page: 3584 article-title: The clinical importance of the metabolite equol‐a clue to the effectiveness of soy and its isoflavones publication-title: J Nutr – volume: 25 start-page: 1389 year: 2004 end-page: 1395 article-title: Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF‐kappaB/AP‐1‐dependent and ‐independent pathways publication-title: Int J Oncol – volume: 89 start-page: 3462 year: 2004 end-page: 3468 article-title: Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys publication-title: J Clin Endocrinol Metab – volume: 78 start-page: 317 year: 1980 end-page: 321 article-title: Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay publication-title: Mutat Res – volume: 62 start-page: 2474 year: 2002 end-page: 2477 article-title: Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen‐dependent human breast cancer (MCF‐7) cells implanted in athymic mice publication-title: Cancer Res – volume: 7 start-page: 1266 year: 1993 end-page: 1274 article-title: Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain publication-title: Mol Endocrinol – volume: 44 start-page: 56 year: 2006 end-page: 80 article-title: Acute, subchronic and chronic safety studies with genistein in rats publication-title: Food Chem Toxicol – volume: 138 start-page: 5067 year: 1997 end-page: 5070 article-title: Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV‐HFO cells publication-title: Endocrinology – volume: 157 start-page: 183 year: 1988 end-page: 189 article-title: Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha‐ras‐transformed NIH 3T3 cells publication-title: Biochem Biophys Res Commun – volume: 32 start-page: 1019 year: 2008 end-page: 1023 article-title: Cytotoxicity of the isoflavone genistein in NIH 3T3 cells publication-title: Cell Biol Int – volume: 26 start-page: 1677 year: 2008 end-page: 1683 article-title: Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case‐control study from the Japan Public Health Center‐based prospective study group publication-title: J Clin Oncol – volume: 51 start-page: 1409 year: 1973 end-page: 1416 article-title: A human cell line from a pleural effusion derived from a breast carcinoma publication-title: J Natl Cancer Inst – volume: 36 start-page: 2146 year: 2000 end-page: 2156 article-title: Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity publication-title: Eur J Cancer – volume: 24 start-page: 5900 year: 2004 end-page: 5913 article-title: BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer publication-title: Mol Cell Biol – volume: 61 start-page: 5045 year: 2001 end-page: 5050 article-title: Soy diets containing varying amounts of genistein stimulate growth of estrogen‐dependent (MCF‐7) tumors in a dose‐dependent manner publication-title: Cancer Res – volume: 26 start-page: 1101 year: 2005 end-page: 1109 article-title: Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors publication-title: Int J Oncol – volume: 91 start-page: 513 year: 2004 end-page: 531 article-title: Phyto‐oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer publication-title: Br J Nutr – volume: 95 start-page: 125 year: 1995 end-page: 133 article-title: Genetic damage and the inhibition of 7,12‐dimethylbenz[a]anthracene‐induced genetic damage by the phytoestrogens, genistein and daidzein, in female ICR mice publication-title: Cancer Lett – volume: 46 start-page: 534 year: 2007 end-page: 542 article-title: Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor‐positive and HER2‐overexpressing human breast cancer cells publication-title: Mol Carcinog – volume: 78 start-page: S593 year: 2003 end-page: S609 article-title: Dietary phytoestrogens and their effect on bone: evidence from and , human observational, and dietary intervention studies publication-title: Am J Clin Nutr – volume: 8 start-page: 469 year: 2005 end-page: 475 article-title: Anticancer activities of pomegranate extracts and genistein in human breast cancer cells publication-title: J Med Food – volume: 18 start-page: 4608 year: 1999 end-page: 4618 article-title: Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist publication-title: EMBO J – volume: 64 start-page: 423 year: 2004 end-page: 428 article-title: Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest publication-title: Cancer Res – volume: 86 start-page: 3045 year: 2001 end-page: 3052 article-title: Effects of an isoflavone‐free soy diet on ovarian hormones in premenopausal women publication-title: J Clin Endocrinol Metab – volume: 71 start-page: 891 year: 2005 end-page: 896 article-title: Repeated oral once daily intake of increasing doses of the novel synthetic genistein product Bonistein in healthy volunteers publication-title: Planta Med – volume: 104 start-page: 13 year: 2007 end-page: 19 article-title: MDA‐MB‐435 cells are derived from M14 melanoma cells – a loss for breast cancer, but a boon for melanoma research publication-title: Breast Cancer Res Treat – volume: 99 start-page: 121 year: 2006 end-page: 134 article-title: Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha publication-title: Breast Cancer Res Treat – volume: 231 start-page: 1150 year: 1986 end-page: 1154 article-title: Sequence and expression of human estrogen receptor complementary DNA publication-title: Science – volume: 138 start-page: 4613 year: 1997 end-page: 4621 article-title: Tissue distribution and quantitative analysis of estrogen receptor‐alpha (ERalpha) and estrogen receptor‐beta (ERbeta) messenger ribonucleic acid in the wild‐type and ERalpha‐knockout mouse publication-title: Endocrinology – volume: 264 start-page: 7066 year: 1989 end-page: 7072 article-title: Distribution and functions of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A‐I and D that catalyzes the esterification and transfer of cell‐derived cholesterol publication-title: J Biol Chem – volume: 27 start-page: 185 year: 2004 end-page: 188 article-title: Interactions of phytoestrogens with estrogen receptors alpha and beta (III). Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine publication-title: Biol Pharm Bull – volume: 94 start-page: 407 year: 2006 end-page: 426 article-title: BRCA1 and BRCA2 as molecular targets for phytochemicals indole‐3‐carbinol and genistein in breast and prostate cancer cells publication-title: Br J Cancer – volume: 15 start-page: 17 year: 1993 end-page: 35 article-title: Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk publication-title: Epidemiol Rev – volume: 63 start-page: 451 year: 1994 end-page: 486 article-title: Molecular mechanisms of action of steroid/thyroid receptor superfamily members publication-title: Annu Rev Biochem – volume: 28 start-page: 1217 year: 2007 end-page: 1223 article-title: Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen‐dependent human breast carcinoma in mice publication-title: Carcinogenesis – volume: 43 start-page: 1461 year: 2005 end-page: 1482 article-title: Subchronic and chronic safety studies with genistein in dogs publication-title: Food Chem Toxicol – volume: 68 start-page: S1431 year: 1998 end-page: S1435 article-title: Effects of soy‐protein supplementation on epithelial proliferation in the histologically normal human breast publication-title: Am J Clin Nutr – volume: 5 start-page: 1541 year: 1998 end-page: 1545 article-title: Effect of dietary soy protein isolate, genistein, and 1,4‐phenylenebis(methylene)selenocyanate on DNA binding of 7,12‐dimethylbenz[a]anthracene in mammary glands of CD rats publication-title: Oncol Rep – volume: 49 start-page: 1857 year: 1989 end-page: 1860 article-title: A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii publication-title: Cancer Res – volume: 10 start-page: R32 year: 2008 article-title: Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer‐Norfolk cohort study publication-title: Breast Cancer Res – volume: 60 start-page: 4112 year: 2000 end-page: 4121 article-title: Decreased ovarian hormones during a soya diet: implications for breast cancer prevention publication-title: Cancer Res – volume: 16 start-page: 837 year: 1996 end-page: 842 article-title: The influence of antiestrogens on pS2 and cathepsin D mRNA induction in MCF‐7 breast cancer cells publication-title: Anticancer Res – volume: 130 start-page: 143 year: 1998 end-page: 152 article-title: Genistein in the control of breast cancer cell growth: insights into the mechanism of action publication-title: Cancer Lett – volume: 77 start-page: 485 year: 2006 end-page: 638 article-title: NTP‐CERHR expert panel report on the reproductive and developmental toxicity of genistein publication-title: Birth Defects Res B Dev Reprod Toxicol – volume: 95 start-page: 406 year: 2006 end-page: 413 article-title: Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines publication-title: Br J Nutr – volume: 262 start-page: 5592 year: 1987 end-page: 5595 article-title: Genistein, a specific inhibitor of tyrosine‐specific protein kinases publication-title: J Biol Chem – volume: 276 start-page: 17808 year: 2001 end-page: 17814 article-title: Estrogen receptor beta‐selective transcriptional activity and recruitment of coregulators by phytoestrogens publication-title: J Biol Chem – volume: 41 start-page: 75 year: 2001 end-page: 81 article-title: Chemopreventive effects of soy protein and purified soy isoflavones on DMBA‐induced mammary tumors in female Sprague‐Dawley rats publication-title: Nutr Cancer – volume: 12 start-page: 2197 year: 2004 end-page: 2207 article-title: Understanding the selectivity of genistein for human estrogen receptor‐beta using X‐ray crystallography and computational methods publication-title: Structure – volume: 12 start-page: 165 year: 2003 end-page: 169 article-title: Mammographic densities in a one‐year isoflavone intervention publication-title: Eur J Cancer Prev – volume: 17 start-page: 587 year: 1996 end-page: 609 article-title: Interaction of steroid hormone receptors with the transcription initiation complex publication-title: Endocr Rev – volume: 7 start-page: 649 year: 2004 end-page: 658 article-title: Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data publication-title: Curr Opin Clin Nutr Metab Care – volume: 134 start-page: 3089 year: 2004 end-page: 3094 article-title: A 2‐year soy intervention in premenopausal women does not change mammographic densities publication-title: J Nutr – volume: 65 start-page: 879 year: 2005 end-page: 886 article-title: Low‐dose dietary phytoestrogen abrogates tamoxifen‐associated mammary tumor prevention publication-title: Cancer Res – volume: 65 start-page: 3396 year: 2005 end-page: 3403 article-title: Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model publication-title: Cancer Res – volume: 44 start-page: 42 year: 2006 end-page: 55 article-title: Genetic toxicity studies with genistein publication-title: Food Chem Toxicol – volume: 16 start-page: 2833 year: 1995 end-page: 2840 article-title: Genistein suppresses mammary cancer in rats publication-title: Carcinogenesis – volume: 53 start-page: 709 year: 2002 end-page: 719 article-title: Estrogenic hormone action in the heart: regulatory network and function publication-title: Cardiovasc Res – volume: 7 start-page: 67 year: 2002 end-page: 76 article-title: Timing of exposure and mammary cancer risk publication-title: J Mammary Gland Biol Neoplasia – volume: 248 start-page: 5736 year: 1973 end-page: 5741 article-title: A specific progesterone‐binding component of human breast cyst fluid publication-title: J Biol Chem – volume: 16 start-page: 885 year: 2006 end-page: 891 article-title: Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer publication-title: Oncol Rep – volume: 85 start-page: 1179 year: 2006 end-page: 1186 article-title: Effects of soy on the mammary glands of premenopausal female monkeys publication-title: Fertil Steril – volume: 54 start-page: 105 year: 1998 end-page: 112 article-title: Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists publication-title: Mol Pharmacol – volume: 163 start-page: 379 year: 1999 end-page: 383 article-title: Estrogen receptor beta – a new dimension in estrogen mechanism of action publication-title: J Endocrinol – volume: 130 start-page: 209 year: 1998 end-page: 216 article-title: Estrogenic and antiproliferative activities on MCF‐7 human breast cancer cells by flavonoids publication-title: Cancer Lett – volume: 119 start-page: 515 year: 2006 end-page: 521 article-title: Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells publication-title: Int J Cancer – volume: 83 start-page: 2223 year: 1998 end-page: 2235 article-title: Clinical review 97: potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence publication-title: J Clin Endocrinol Metab – volume: 131 start-page: 2957 year: 2001 end-page: 2962 article-title: Physiological concentrations of dietary genistein dose‐dependently stimulate growth of estrogen‐dependent human breast cancer (MCF‐7) tumors implanted in athymic nude mice publication-title: J Nutr – volume: 60 start-page: 1299 year: 2000 end-page: 1305 article-title: Increased urinary excretion of 2‐hydroxyestrone but not 16alpha‐hydroxyestrone in premenopausal women during a soya diet containing isoflavones publication-title: Cancer Res – volume: 26 start-page: 197 year: 2005 end-page: 203 article-title: Caloric restriction reduces cell loss and maintains estrogen receptor‐alpha immunoreactivity in the pre‐optic hypothalamus of female B6D2F1 mice publication-title: Neuro Endocrinol Lett – volume: 105 start-page: 312 year: 2003 end-page: 320 article-title: Cell‐transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells publication-title: Int J Cancer – volume: 269 start-page: 226 year: 2008 end-page: 242 article-title: Multi‐targeted therapy of cancer by genistein publication-title: Cancer Lett – volume: 146 start-page: 839 year: 2007 end-page: 847 article-title: Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial publication-title: Ann Intern Med – volume: 79 start-page: 1 year: 2007 end-page: 98 article-title: NTP toxicity report of reproductive dose range‐finding study of genistein (CAS No. 446‐72‐0) administered in feed to sprague‐dawley rats publication-title: Toxic Rep Ser – volume: 20 start-page: 1 year: 1993 end-page: 12 article-title: Inhibition of tumor promoter‐induced hydrogen peroxide formation and by genistein publication-title: Nutr Cancer – volume: 90 start-page: 1936 year: 2005 end-page: 1941 article-title: Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women publication-title: J Clin Endocrinol Metab – volume: 71 start-page: S1705 year: 2000 end-page: S1707 article-title: Protection against breast cancer with genistein: a component of soy publication-title: Am J Clin Nutr – volume: 7 start-page: 1133 year: 1998 end-page: 1144 article-title: Mammographic densities and breast cancer risk publication-title: Cancer Epidemiol Biomarkers Prev – volume: 93 start-page: 4787 year: 2008 end-page: 4796 article-title: Breast safety and efficacy of genistein aglycone for post‐menopausal bone loss: a follow‐up study publication-title: J Clin Endocrinol Metab – volume: 1 start-page: 49 year: 2008 article-title: The molecular basis of phytoestrogen genistein induced mitotic arrest and exit of self‐renewal in embryonal carcinoma and primary cancer cell lines publication-title: BMC Med Genomics – volume: 98 start-page: 1275 year: 2006 end-page: 1284 article-title: Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings publication-title: J Natl Cancer Inst – volume: 20 start-page: 1449 year: 2002 end-page: 1455 article-title: Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial publication-title: J Clin Oncol – volume: 66 start-page: 1241 year: 2006 end-page: 1249 article-title: Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast publication-title: Cancer Res – volume: 11 start-page: S925 year: 2005 end-page: S930 article-title: Tamoxifen versus aromatase inhibitors for breast cancer prevention publication-title: Clin Cancer Res – volume: 57 start-page: 3071 year: 1997 end-page: 3078 article-title: MCF‐7: the first hormone‐responsive breast cancer cell line publication-title: Cancer Res – volume: 12 start-page: 617 year: 2003 end-page: 631 article-title: Phytoestrogens: potential benefits and implications for breast cancer survivors publication-title: J Womens Health (Larchmt) – volume: 131 start-page: S1362 year: 2001 end-page: S1375 article-title: Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements publication-title: J Nutr – volume: 11 start-page: 400 year: 2004 end-page: 404 article-title: Effects of genistein on hot flushes in early postmenopausal women: a randomized, double‐blind EPT‐ and placebo‐controlled study publication-title: Menopause – volume: 56 start-page: 128 year: 2006 end-page: 135 article-title: Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women publication-title: Nutr Cancer – volume: 101 start-page: 1213 year: 2003 end-page: 1220 article-title: A randomized placebo‐controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients publication-title: Obstet Gynecol – volume: 90 start-page: 967 year: 1998 end-page: 971 article-title: Antiestrogenic action of raloxifene and tamoxifen: today and tomorrow publication-title: J Natl Cancer Inst – volume: 27 start-page: 1292 year: 2006 end-page: 1299 article-title: Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations publication-title: Carcinogenesis – volume: 93 start-page: 5925 year: 1996 end-page: 5930 article-title: Cloning of a novel receptor expressed in rat prostate and ovary publication-title: Proc Natl Acad Sci USA – volume: 10 start-page: 389 year: 2005 end-page: 394 article-title: Dietary phytoestrogen intake and mammographic density – results of a pilot study publication-title: Eur J Med Res – volume: 91 start-page: 164 year: 2000 end-page: 173 article-title: p53‐independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells publication-title: Japan J Cancer Res – volume: 139 start-page: 4252 year: 1998 end-page: 4263 article-title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta publication-title: Endocrinology – volume: 389 start-page: 753 year: 1997 end-page: 758 article-title: Molecular basis of agonism and antagonism in the oestrogen receptor publication-title: Nature – volume: 65 start-page: 6934 year: 2005 end-page: 6942 article-title: Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells publication-title: Cancer Res – volume: 25 start-page: 211 year: 2004 end-page: 218 article-title: Dietary genistein results in larger MNU‐induced, estrogen‐dependent mammary tumors following ovariectomy of Sprague‐Dawley rats publication-title: Carcinogenesis – volume: 49 start-page: 59 year: 2004 end-page: 65 article-title: A pilot clinical study of short‐term isoflavone supplements in breast cancer patients publication-title: Nutr Cancer – volume: 85 start-page: 1819 year: 1993 end-page: 1827 article-title: Migration patterns and breast cancer risk in Asian‐American women publication-title: J Natl Cancer Inst – volume: 11 start-page: 835 year: 1996 end-page: 842 article-title: A controlled trial of raloxifene (LY139481) HCl: impact on bone turnover and serum lipid profile in healthy postmenopausal women publication-title: J Bone Miner Res – volume: 444 start-page: 213 year: 2004 end-page: 223 article-title: Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular‐based classification publication-title: Virchows Arch – volume: 58 start-page: 773 year: 2006 end-page: 781 article-title: International Union of Pharmacology. LXIV. Estrogen receptors publication-title: Pharmacol Rev – volume: 89 start-page: 3462 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB106 article-title: Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-032067 contributor: fullname: Wood – volume: 22 start-page: 4702 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB77 article-title: Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1206583 contributor: fullname: Gong – volume: 61 start-page: 1 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB2 article-title: Soy isoflavones: a safety review publication-title: Nutr Rev doi: 10.1301/nr.2003.janr.1-33 contributor: fullname: Munro – volume: 25 start-page: 1389 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB71 article-title: Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways publication-title: Int J Oncol contributor: fullname: Valachovicova – volume: 51 start-page: 1409 year: 1973 ident: 10.1111/j.1753-4887.2009.00213.x-BIB63 article-title: A human cell line from a pleural effusion derived from a breast carcinoma publication-title: J Natl Cancer Inst doi: 10.1093/jnci/51.5.1409 contributor: fullname: Soule – volume: 75 start-page: 477 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB109 article-title: Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys publication-title: Biol Reprod doi: 10.1095/biolreprod.106.052142 contributor: fullname: Wood – volume: 16 start-page: 837 year: 1996 ident: 10.1111/j.1753-4887.2009.00213.x-BIB124 article-title: The influence of antiestrogens on pS2 and cathepsin D mRNA induction in MCF-7 breast cancer cells publication-title: Anticancer Res contributor: fullname: Rajah – volume: 44 start-page: 42 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB130 article-title: Genetic toxicity studies with genistein publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2005.06.004 contributor: fullname: Michael McClain – volume: 392 start-page: 49 year: 1996 ident: 10.1111/j.1753-4887.2009.00213.x-BIB17 article-title: ER beta: identification and characterization of a novel human estrogen receptor publication-title: FEBS Lett doi: 10.1016/0014-5793(96)00782-X contributor: fullname: Mosselman – volume: 269 start-page: 226 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB85 article-title: Multi-targeted therapy of cancer by genistein publication-title: Cancer Lett doi: 10.1016/j.canlet.2008.03.052 contributor: fullname: Banerjee – volume: 62 start-page: 2474 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB110 article-title: Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice publication-title: Cancer Res contributor: fullname: Ju – volume: 11 start-page: 835 year: 1996 ident: 10.1111/j.1753-4887.2009.00213.x-BIB44 article-title: A controlled trial of raloxifene (LY139481) HCl: impact on bone turnover and serum lipid profile in healthy postmenopausal women publication-title: J Bone Miner Res doi: 10.1002/jbmr.5650110615 contributor: fullname: Draper – volume: 32 start-page: 1019 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB62 article-title: Cytotoxicity of the isoflavone genistein in NIH 3T3 cells publication-title: Cell Biol Int doi: 10.1016/j.cellbi.2008.04.004 contributor: fullname: Rucinska – volume: 12 start-page: 617 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB128 article-title: Phytoestrogens: potential benefits and implications for breast cancer survivors publication-title: J Womens Health (Larchmt) doi: 10.1089/154099903322404276 contributor: fullname: Duffy – volume: 95 start-page: 125 year: 1995 ident: 10.1111/j.1753-4887.2009.00213.x-BIB58 article-title: Genetic damage and the inhibition of 7,12-dimethylbenz[a]anthracene-induced genetic damage by the phytoestrogens, genistein and daidzein, in female ICR mice publication-title: Cancer Lett doi: 10.1016/0304-3835(95)03877-Y contributor: fullname: Giri – volume: 65 start-page: 6934 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB74 article-title: Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-4604 contributor: fullname: Li – volume: 389 start-page: 753 year: 1997 ident: 10.1111/j.1753-4887.2009.00213.x-BIB42 article-title: Molecular basis of agonism and antagonism in the oestrogen receptor publication-title: Nature doi: 10.1038/39645 contributor: fullname: Brzozowski – volume: 84 start-page: 4017 year: 1999 ident: 10.1111/j.1753-4887.2009.00213.x-BIB122 article-title: Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast publication-title: J Clin Endocrinol Metab contributor: fullname: Hargreaves – volume: 119 start-page: 515 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB92 article-title: Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro publication-title: Int J Cancer doi: 10.1002/ijc.21863 contributor: fullname: Limer – volume: 81 start-page: 6344 year: 1984 ident: 10.1111/j.1753-4887.2009.00213.x-BIB123 article-title: Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.81.20.6344 contributor: fullname: Brown – ident: 10.1111/j.1753-4887.2009.00213.x-BIB61 – volume: 151 start-page: 151 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB55 article-title: Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells publication-title: Toxicol Lett doi: 10.1016/j.toxlet.2004.04.005 contributor: fullname: Di Virgilio – volume: 262 start-page: 5592 year: 1987 ident: 10.1111/j.1753-4887.2009.00213.x-BIB80 article-title: Genistein, a specific inhibitor of tyrosine-specific protein kinases publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)45614-1 contributor: fullname: Akiyama – volume: 90 start-page: 1936 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB32 article-title: Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1428 contributor: fullname: Teede – volume: 49 start-page: 1857 year: 1989 ident: 10.1111/j.1753-4887.2009.00213.x-BIB137 article-title: A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii publication-title: Cancer Res contributor: fullname: Severson – volume: 36 start-page: 2146 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB82 article-title: Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity publication-title: Eur J Cancer doi: 10.1016/S0959-8049(00)00300-2 contributor: fullname: Cho – volume: 95 start-page: 406 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB87 article-title: Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines publication-title: Br J Nutr doi: 10.1079/BJN20051640 contributor: fullname: Caetano – volume: 231 start-page: 1150 year: 1986 ident: 10.1111/j.1753-4887.2009.00213.x-BIB16 article-title: Sequence and expression of human estrogen receptor complementary DNA publication-title: Science doi: 10.1126/science.3753802 contributor: fullname: Greene – volume: 26 start-page: 197 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB21 article-title: Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice publication-title: Neuro Endocrinol Lett contributor: fullname: Yaghmaie – volume: 91 start-page: 164 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB83 article-title: p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells publication-title: Japan J Cancer Res doi: 10.1111/j.1349-7006.2000.tb00928.x contributor: fullname: Choi – volume: 91 start-page: 513 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB1 article-title: Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer publication-title: Br J Nutr doi: 10.1079/BJN20031075 contributor: fullname: Magee – volume: 248 start-page: 5736 year: 1973 ident: 10.1111/j.1753-4887.2009.00213.x-BIB126 article-title: A specific progesterone-binding component of human breast cyst fluid publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)43566-7 contributor: fullname: Pearlman – volume: 147 start-page: 4831 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB41 article-title: Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells publication-title: Endocrinology doi: 10.1210/en.2006-0563 contributor: fullname: Chang – volume: 93 start-page: 4787 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB36 article-title: Breast safety and efficacy of genistein aglycone for post-menopausal bone loss: a follow-up study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1087 contributor: fullname: Marini – volume: 7 start-page: 1266 year: 1993 ident: 10.1111/j.1753-4887.2009.00213.x-BIB24 article-title: Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain publication-title: Mol Endocrinol contributor: fullname: Beekman – volume: 51 start-page: 7632 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB38 article-title: Phytoestrogens modulate binding response of estrogen receptors alpha and beta to the estrogen response element publication-title: J Agric Food Chem doi: 10.1021/jf034427b contributor: fullname: Kostelac – volume: 10 start-page: 389 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB140 article-title: Dietary phytoestrogen intake and mammographic density - results of a pilot study publication-title: Eur J Med Res contributor: fullname: Nagel – volume: 28 start-page: 1217 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB70 article-title: Soy phytochemicals synergistically enhance the preventive effect of tamoxifen on the growth of estrogen-dependent human breast carcinoma in mice publication-title: Carcinogenesis doi: 10.1093/carcin/bgm004 contributor: fullname: Mai – volume: 264 start-page: 7066 year: 1989 ident: 10.1111/j.1753-4887.2009.00213.x-BIB125 article-title: Distribution and functions of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)83541-4 contributor: fullname: Francone – volume: 85 start-page: 1200 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB50 article-title: Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors publication-title: J Clin Endocrinol Metab contributor: fullname: Chu – volume: 11 start-page: 195 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB117 article-title: A randomized isoflavone intervention among premenopausal women publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Maskarinec – volume: 138 start-page: 4613 year: 1997 ident: 10.1111/j.1753-4887.2009.00213.x-BIB22 article-title: Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse publication-title: Endocrinology doi: 10.1210/endo.138.11.5496 contributor: fullname: Couse – volume: 84 start-page: 474 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB34 article-title: The effect of the phytoestrogen genistein and hormone replacement therapy on homocysteine and C-reactive protein level in postmenopausal women publication-title: Acta Obstet Gynecol Scand doi: 10.1111/j.0001-6349.2005.00661.x contributor: fullname: D'Anna – volume: 53 start-page: 709 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB23 article-title: Estrogenic hormone action in the heart: regulatory network and function publication-title: Cardiovasc Res doi: 10.1016/S0008-6363(01)00526-0 contributor: fullname: Babiker – volume: 138 start-page: 863 year: 1997 ident: 10.1111/j.1753-4887.2009.00213.x-BIB28 article-title: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta publication-title: Endocrinology doi: 10.1210/endo.138.3.4979 contributor: fullname: Kuiper – volume: 320 start-page: 134 year: 1986 ident: 10.1111/j.1753-4887.2009.00213.x-BIB15 article-title: Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A publication-title: Nature doi: 10.1038/320134a0 contributor: fullname: Green – volume: 17 start-page: 1904 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB8 article-title: Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: a randomized double-blind placebo-controlled study publication-title: J Bone Miner Res doi: 10.1359/jbmr.2002.17.10.1904 contributor: fullname: Morabito – volume: 276 start-page: 17808 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB47 article-title: Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens publication-title: J Biol Chem doi: 10.1074/jbc.M100953200 contributor: fullname: An – volume: 44 start-page: 56 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB56 article-title: Acute, subchronic and chronic safety studies with genistein in rats publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2005.05.021 contributor: fullname: Michael McClain – volume: 18 start-page: 4608 year: 1999 ident: 10.1111/j.1753-4887.2009.00213.x-BIB37 article-title: Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist publication-title: EMBO J doi: 10.1093/emboj/18.17.4608 contributor: fullname: Pike – volume: 34 start-page: 633 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB113 article-title: Cellular functions of the BRCA tumour-suppressor proteins publication-title: Biochem Soc Trans doi: 10.1042/BST0340633 contributor: fullname: Boulton – volume: 54 start-page: 105 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB31 article-title: Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists publication-title: Mol Pharmacol doi: 10.1124/mol.54.1.105 contributor: fullname: Barkhem – volume: 12 start-page: 2197 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB43 article-title: Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods publication-title: Structure doi: 10.1016/j.str.2004.09.015 contributor: fullname: Manas – volume: 66 start-page: 1241 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB108 article-title: Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-2067 contributor: fullname: Wood – volume: 281 start-page: 17909 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB30 article-title: Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity publication-title: J Biol Chem doi: 10.1074/jbc.M513684200 contributor: fullname: Hsieh – volume: 60 start-page: 4112 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB120 article-title: Decreased ovarian hormones during a soya diet: implications for breast cancer prevention publication-title: Cancer Res contributor: fullname: Lu – volume: 444 start-page: 213 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB49 article-title: Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification publication-title: Virchows Arch doi: 10.1007/s00428-003-0947-3 contributor: fullname: Lax – volume: 43 start-page: 1461 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB54 article-title: Subchronic and chronic safety studies with genistein in dogs publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2005.02.017 contributor: fullname: McClain – volume: 24 start-page: 5900 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB112 article-title: BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer publication-title: Mol Cell Biol doi: 10.1128/MCB.24.13.5900-5913.2004 contributor: fullname: Razandi – volume: 134 start-page: 3089 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB115 article-title: A 2-year soy intervention in premenopausal women does not change mammographic densities publication-title: J Nutr doi: 10.1093/jn/134.11.3089 contributor: fullname: Maskarinec – volume: 98 start-page: 459 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB3 article-title: Meta-analysis of soy intake and breast cancer risk publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djj102 contributor: fullname: Trock – volume: 61 start-page: 5045 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB7 article-title: Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner publication-title: Cancer Res contributor: fullname: Allred – volume: 7 start-page: 649 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB4 article-title: Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data publication-title: Curr Opin Clin Nutr Metab Care doi: 10.1097/00075197-200411000-00010 contributor: fullname: Messina – volume: 65 start-page: 3396 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB104 article-title: Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-4109 contributor: fullname: Vantyghem – volume: 85 start-page: 1179 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB107 article-title: Effects of soy on the mammary glands of premenopausal female monkeys publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2005.08.059 contributor: fullname: Wood – volume: 86 start-page: 3045 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB121 article-title: Effects of an isoflavone-free soy diet on ovarian hormones in premenopausal women publication-title: J Clin Endocrinol Metab contributor: fullname: Lu – volume: 93 start-page: 5925 year: 1996 ident: 10.1111/j.1753-4887.2009.00213.x-BIB18 article-title: Cloning of a novel receptor expressed in rat prostate and ovary publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.12.5925 contributor: fullname: Kuiper – volume: 130 start-page: 143 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB64 article-title: Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro publication-title: Cancer Lett doi: 10.1016/S0304-3835(98)00130-X contributor: fullname: Fioravanti – volume: 11 start-page: 608 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB141 article-title: Mammographic parenchymal patterns and self-reported soy intake in Singapore Chinese women publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Jakes – volume: 5 start-page: 1541 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB97 article-title: Effect of dietary soy protein isolate, genistein, and 1,4-phenylenebis(methylene)selenocyanate on DNA binding of 7,12-dimethylbenz[a]anthracene in mammary glands of CD rats publication-title: Oncol Rep contributor: fullname: Upadhyaya – volume: 139 start-page: 4252 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB29 article-title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta publication-title: Endocrinology doi: 10.1210/endo.139.10.6216 contributor: fullname: Kuiper – volume: 28 start-page: e90 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB76 article-title: Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line publication-title: Pancreas doi: 10.1097/00006676-200405000-00020 contributor: fullname: Li – volume: 12 start-page: 186 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB35 article-title: Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women publication-title: Menopause doi: 10.1097/00042192-200512020-00013 contributor: fullname: Crisafulli – volume: 77 start-page: 485 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB57 article-title: NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein publication-title: Birth Defects Res B Dev Reprod Toxicol doi: 10.1002/bdrb.20087 contributor: fullname: Rozman – volume: 8 start-page: 469 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB67 article-title: Anticancer activities of pomegranate extracts and genistein in human breast cancer cells publication-title: J Med Food doi: 10.1089/jmf.2005.8.469 contributor: fullname: Jeune – volume: 90 start-page: 128 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB33 article-title: Effects of raloxifene, hormone therapy, and soy isoflavone on serum high-sensitive C-reactive protein in postmenopausal women publication-title: Int J Gynaecol Obstet doi: 10.1016/j.ijgo.2005.05.005 contributor: fullname: Yildiz – volume: 55 start-page: 1 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB5 article-title: Estimated Asian adult soy protein and isoflavone intakes publication-title: Nutr Cancer doi: 10.1207/s15327914nc5501_1 contributor: fullname: Messina – volume: 101 start-page: 1213 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB131 article-title: A randomized placebo-controlled crossover trial with phytoestrogens in treatment of menopause in breast cancer patients publication-title: Obstet Gynecol contributor: fullname: Nikander – volume: 253 start-page: 38 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB91 article-title: Genistein-mediated attenuation of tamoxifen-induced antagonism from estrogen receptor-regulated genes publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1998.9751 contributor: fullname: Schwartz – volume: 104 start-page: 13 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB105 article-title: MDA-MB-435 cells are derived from M14 melanoma cells - a loss for breast cancer, but a boon for melanoma research publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-006-9392-8 contributor: fullname: Rae – volume: 25 start-page: 648 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB139 article-title: Plasma phytoestrogens and subsequent breast cancer risk publication-title: J Clin Oncol doi: 10.1200/JCO.2006.06.0244 contributor: fullname: Verheus – volume: 11 start-page: 400 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB12 article-title: Effects of genistein on hot flushes in early postmenopausal women: a randomized, double-blind EPT- and placebo-controlled study publication-title: Menopause doi: 10.1097/01.GME.0000109314.11228.E5 contributor: fullname: Crisafulli – volume: 101 start-page: 1566 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB40 article-title: Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0308319100 contributor: fullname: Strom – ident: 10.1111/j.1753-4887.2009.00213.x-BIB60 – volume: 24 start-page: 7681 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB19 article-title: Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways publication-title: Mol Cell Biol doi: 10.1128/MCB.24.17.7681-7694.2004 contributor: fullname: Li – volume: 83 start-page: 2223 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB134 article-title: Clinical review 97: potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence publication-title: J Clin Endocrinol Metab contributor: fullname: Tham – volume: 1 start-page: 49 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB79 article-title: The molecular basis of phytoestrogen genistein induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines publication-title: BMC Med Genomics doi: 10.1186/1755-8794-1-49 contributor: fullname: Regenbrecht – volume: 60 start-page: 1299 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB119 article-title: Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones publication-title: Cancer Res contributor: fullname: Lu – volume: 25 start-page: 211 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB94 article-title: Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats publication-title: Carcinogenesis doi: 10.1093/carcin/bgg198 contributor: fullname: Allred – volume: 12 start-page: 165 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB116 article-title: Mammographic densities in a one-year isoflavone intervention publication-title: Eur J Cancer Prev doi: 10.1097/00008469-200304000-00011 contributor: fullname: Maskarinec – volume: 90 start-page: 967 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB46 article-title: Antiestrogenic action of raloxifene and tamoxifen: today and tomorrow publication-title: J Natl Cancer Inst doi: 10.1093/jnci/90.13.967 contributor: fullname: Jordan – volume: 20 start-page: 1 year: 1993 ident: 10.1111/j.1753-4887.2009.00213.x-BIB84 article-title: Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein publication-title: Nutr Cancer doi: 10.1080/01635589309514265 contributor: fullname: Wei – volume: 14 start-page: 648 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB11 article-title: Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study publication-title: Menopause doi: 10.1097/01.gme.0000248708.60698.98 contributor: fullname: D'Anna – volume: 105 start-page: 312 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB51 article-title: Cell-transforming activity and mutagenicity of 5 phytoestrogens in cultured mammalian cells publication-title: Int J Cancer doi: 10.1002/ijc.11046 contributor: fullname: Tsutsui – volume: 34 start-page: 67 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB68 article-title: Effect of apoptosis in human breast cancer cells and its probable mechanisms by genistein publication-title: Wei Sheng Yan Jiu contributor: fullname: Liu – volume: 589 start-page: 22 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB114 article-title: Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2008.04.049 contributor: fullname: Atteritano – volume: 63 start-page: 451 year: 1994 ident: 10.1111/j.1753-4887.2009.00213.x-BIB25 article-title: Molecular mechanisms of action of steroid/thyroid receptor superfamily members publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.63.070194.002315 contributor: fullname: Tsai – volume: 26 start-page: 1101 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB78 article-title: Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors publication-title: Int J Oncol contributor: fullname: Kousidou – volume: 98 start-page: 1275 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB96 article-title: Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djj356 contributor: fullname: Messina – volume: 49 start-page: 59 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB129 article-title: A pilot clinical study of short-term isoflavone supplements in breast cancer patients publication-title: Nutr Cancer doi: 10.1207/s15327914nc4901_8 contributor: fullname: Sartippour – volume: 163 start-page: 379 year: 1999 ident: 10.1111/j.1753-4887.2009.00213.x-BIB45 article-title: Estrogen receptor beta - a new dimension in estrogen mechanism of action publication-title: J Endocrinol doi: 10.1677/joe.0.1630379 contributor: fullname: Gustafsson – volume: 79 start-page: 1 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB59 article-title: NTP toxicity report of reproductive dose range-finding study of genistein (CAS No. 446-72-0) administered in feed to sprague-dawley rats publication-title: Toxic Rep Ser contributor: fullname: Delclos – volume: 138 start-page: 5067 year: 1997 ident: 10.1111/j.1753-4887.2009.00213.x-BIB20 article-title: Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells publication-title: Endocrinology doi: 10.1210/endo.138.11.5652 contributor: fullname: Arts – volume: 10 start-page: R32 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB146 article-title: Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study publication-title: Breast Cancer Res doi: 10.1186/bcr1995 contributor: fullname: Ward – volume: 113 start-page: 149 issue: 114 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB73 article-title: Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent publication-title: Res Commun Mol Pathol Pharmacol contributor: fullname: Satoh – volume: 94 start-page: 407 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB86 article-title: BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells publication-title: Br J Cancer doi: 10.1038/sj.bjc.6602935 contributor: fullname: Fan – volume: 130 start-page: 1665 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB93 article-title: Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice publication-title: J Nutr doi: 10.1093/jn/130.7.1665 contributor: fullname: Santell – volume: 56 start-page: 128 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB142 article-title: Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women publication-title: Nutr Cancer doi: 10.1207/s15327914nc5602_2 contributor: fullname: Ursin – volume: 89 start-page: 1779 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB102 article-title: Phytoestrogens are potent inhibitors of estrogen sulfation: implications for breast cancer risk and treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-031631 contributor: fullname: Harris – volume: 116 start-page: 561 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB14 article-title: Estrogen receptors and human disease publication-title: J Clin Invest doi: 10.1172/JCI27987 contributor: fullname: Deroo – volume: 106 start-page: 1260 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB75 article-title: Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenografts publication-title: Cancer doi: 10.1002/cncr.21731 contributor: fullname: Mohammad – volume: 15 start-page: 17 year: 1993 ident: 10.1111/j.1753-4887.2009.00213.x-BIB118 article-title: Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk publication-title: Epidemiol Rev doi: 10.1093/oxfordjournals.epirev.a036102 contributor: fullname: Pike – volume: 65 start-page: 879 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB89 article-title: Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention publication-title: Cancer Res doi: 10.1158/0008-5472.879.65.3 contributor: fullname: Liu – volume: 146 start-page: 839 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB9 article-title: Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-12-200706190-00005 contributor: fullname: Marini – volume: 29 start-page: 611 year: 1982 ident: 10.1111/j.1753-4887.2009.00213.x-BIB136 article-title: Geographic pathology of latent prostatic carcinoma publication-title: Int J Cancer doi: 10.1002/ijc.2910290602 contributor: fullname: Yatani – volume: 17 start-page: 587 year: 1996 ident: 10.1111/j.1753-4887.2009.00213.x-BIB26 article-title: Interaction of steroid hormone receptors with the transcription initiation complex publication-title: Endocr Rev doi: 10.1210/edrv-17-6-587 contributor: fullname: Beato – volume: 116 start-page: 561 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB27 article-title: Estrogen receptors and human disease publication-title: J Clin Invest doi: 10.1172/JCI27987 contributor: fullname: Deroo – volume: 78 start-page: S593 year: 2003 ident: 10.1111/j.1753-4887.2009.00213.x-BIB145 article-title: Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies publication-title: Am J Clin Nutr doi: 10.1093/ajcn/78.3.593S contributor: fullname: Setchell – volume: 157 start-page: 183 year: 1988 ident: 10.1111/j.1753-4887.2009.00213.x-BIB81 article-title: Effect of genistein on topoisomerase activity and on the growth of [Val 12]Ha-ras-transformed NIH 3T3 cells publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(88)80030-5 contributor: fullname: Okura – volume: 41 start-page: 75 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB100 article-title: Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats publication-title: Nutr Cancer doi: 10.1080/01635581.2001.9680615 contributor: fullname: Constantinou – volume: 588 start-page: 158 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB88 article-title: Genistein induces apoptosis in ovarian cancer cells via different molecular pathways depending on breast cancer susceptibility gene-1 (BRCA1) status publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2008.04.041 contributor: fullname: Thasni – volume: 85 start-page: 1819 year: 1993 ident: 10.1111/j.1753-4887.2009.00213.x-BIB135 article-title: Migration patterns and breast cancer risk in Asian-American women publication-title: J Natl Cancer Inst doi: 10.1093/jnci/85.22.1819 contributor: fullname: Ziegler – volume: 20 start-page: 1449 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB132 article-title: Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial publication-title: J Clin Oncol doi: 10.1200/JCO.2002.20.6.1449 contributor: fullname: Van Patten – volume: 16 start-page: 885 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB69 article-title: Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer publication-title: Oncol Rep contributor: fullname: Farina – volume: 71 start-page: S1705 year: 2000 ident: 10.1111/j.1753-4887.2009.00213.x-BIB101 article-title: Protection against breast cancer with genistein: a component of soy publication-title: Am J Clin Nutr doi: 10.1093/ajcn/71.6.1705S contributor: fullname: Lamartiniere – volume: 58 start-page: 3833 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB66 article-title: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo publication-title: Cancer Res contributor: fullname: Hsieh – volume: 64 start-page: 423 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB39 article-title: Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-03-2446 contributor: fullname: Paruthiyil – volume: 131 start-page: S1362 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB52 article-title: Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements publication-title: J Nutr doi: 10.1093/jn/131.4.1362S contributor: fullname: Setchell – volume: 71 start-page: 891 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB53 article-title: Repeated oral once daily intake of increasing doses of the novel synthetic genistein product Bonistein in healthy volunteers publication-title: Planta Med doi: 10.1055/s-2005-864186 contributor: fullname: Ullmann – volume: 27 start-page: 185 year: 2004 ident: 10.1111/j.1753-4887.2009.00213.x-BIB90 article-title: Interactions of phytoestrogens with estrogen receptors alpha and beta (III). Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine publication-title: Biol Pharm Bull doi: 10.1248/bpb.27.185 contributor: fullname: Kinjo – volume: 11 start-page: S925 year: 2005 ident: 10.1111/j.1753-4887.2009.00213.x-BIB48 article-title: Tamoxifen versus aromatase inhibitors for breast cancer prevention publication-title: Clin Cancer Res doi: 10.1158/1078-0432.925s.11.2 contributor: fullname: Yue – volume: 57 start-page: 3071 year: 1997 ident: 10.1111/j.1753-4887.2009.00213.x-BIB103 article-title: MCF-7: the first hormone-responsive breast cancer cell line publication-title: Cancer Res contributor: fullname: Levenson – volume: 131 start-page: 2957 year: 2001 ident: 10.1111/j.1753-4887.2009.00213.x-BIB95 article-title: Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice publication-title: J Nutr doi: 10.1093/jn/131.11.2957 contributor: fullname: Ju – volume: 58 start-page: 773 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB13 article-title: International Union of Pharmacology. LXIV. Estrogen receptors publication-title: Pharmacol Rev doi: 10.1124/pr.58.4.8 contributor: fullname: Dahlman-Wright – volume: 46 start-page: 534 year: 2007 ident: 10.1111/j.1753-4887.2009.00213.x-BIB72 article-title: Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells publication-title: Mol Carcinog doi: 10.1002/mc.20300 contributor: fullname: Mai – volume: 68 start-page: S1431 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB127 article-title: Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast publication-title: Am J Clin Nutr doi: 10.1093/ajcn/68.6.1431S contributor: fullname: McMichael-Phillips – volume: 99 start-page: 121 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB6 article-title: Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-006-9191-2 contributor: fullname: Seo – volume: 7 start-page: 67 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB99 article-title: Timing of exposure and mammary cancer risk publication-title: J Mammary Gland Biol Neoplasia doi: 10.1023/A:1015722507237 contributor: fullname: Lamartiniere – volume: 132 start-page: 3577 year: 2002 ident: 10.1111/j.1753-4887.2009.00213.x-BIB144 article-title: The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones publication-title: J Nutr doi: 10.1093/jn/132.12.3577 contributor: fullname: Setchell – volume: 23 start-page: 715 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB10 article-title: OPG and sRANKL serum concentrations in osteopenic, postmenopausal women after 2-year genistein administration publication-title: J Bone Miner Res doi: 10.1359/jbmr.080201 contributor: fullname: Marini – volume: 26 start-page: 1677 year: 2008 ident: 10.1111/j.1753-4887.2009.00213.x-BIB138 article-title: Plasma isoflavone level and subsequent risk of breast cancer among Japanese women: a nested case-control study from the Japan Public Health Center-based prospective study group publication-title: J Clin Oncol doi: 10.1200/JCO.2007.13.9964 contributor: fullname: Iwasaki – volume: 78 start-page: 317 year: 1980 ident: 10.1111/j.1753-4887.2009.00213.x-BIB133 article-title: Lack of mutagenicity of some phytoestrogens in the salmonella/mammalian microsome assay publication-title: Mutat Res doi: 10.1016/0165-1218(80)90036-1 contributor: fullname: Bartholomew – volume: 7 start-page: 1133 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB143 article-title: Mammographic densities and breast cancer risk publication-title: Cancer Epidemiol Biomarkers Prev contributor: fullname: Boyd – volume: 16 start-page: 2833 year: 1995 ident: 10.1111/j.1753-4887.2009.00213.x-BIB98 article-title: Genistein suppresses mammary cancer in rats publication-title: Carcinogenesis doi: 10.1093/carcin/16.11.2833 contributor: fullname: Lamartiniere – volume: 130 start-page: 209 year: 1998 ident: 10.1111/j.1753-4887.2009.00213.x-BIB65 article-title: Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids publication-title: Cancer Lett doi: 10.1016/S0304-3835(98)00141-4 contributor: fullname: Le Bail – volume: 27 start-page: 1292 year: 2006 ident: 10.1111/j.1753-4887.2009.00213.x-BIB111 article-title: Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations publication-title: Carcinogenesis doi: 10.1093/carcin/bgi370 contributor: fullname: Ju |
| SSID | ssj0001293 |
| Score | 2.4257934 |
| SecondaryResourceType | review_article |
| Snippet | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone... |
| SourceID | proquest crossref pubmed pascalfrancis wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 398 |
| SubjectTerms | Animals Anticarcinogenic Agents - pharmacology Biological and medical sciences Breast cancer cancer risk Clinical Trials as Topic Dietary supplements Effects Epidemiologic Studies Epidemiology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology genistein Genistein - pharmacology Humans Isoflavones - pharmacology Meta-analysis Mice Neoplasms - prevention & control osteoporosis postmenopausal Prostate cancer Rats Risk factors Soybean Proteins - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| Title | The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies |
| URI | https://api.istex.fr/ark:/67375/WNG-2WLZF1QK-H/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1753-4887.2009.00213.x https://www.ncbi.nlm.nih.gov/pubmed/19566600 https://www.proquest.com/docview/212329221 https://search.proquest.com/docview/67438970 |
| Volume | 67 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbK9gAvCMYtDIYf0F5YUBLnUvPGpaUapRMo1SpeLOeGClM6LSna-PWcE9tJiooYvERWWruuvi_H5zjf8SHkuZP4clhk3JZRAAHKkEc2l9y1iwR8pMjlacoxG_njLJzM_eNFsBgM-qqldZ28TH9uzSv5H1ThHuCKWbL_gGw7KNyANuALV0AYrtfGWAky0OeDryFmy_KF_Hp2BXFujm8CUoRVCSV1E9XkKse5y1uBTj-Wtcp5OQcjqPMljbazy5_syQ6_mcxdfZ6_Hq510rvNgN4JBt22qqmWrLTd3a5sT0VyLK-6Xdw3uPuq7jeE1JlpZseCt-pWWHCUlYUYCXihV1pthlVVDk23qGdTmSpTrZdnX2V__tnym7HNWaSey4witH_Y9uxEjOfTqYhHi_gG2fUiHqAiND5ZtAs5ukK_ib-2jb3h0ewi0JeosJUVwFKo6ijbwpfNaKhxZ-I75LaOQ-hrRaq7ZJCXe8R6t8xrekj1YbFntMV2j9w0KezVPVIB8agiHl0VtCUeNcSjq5IqtlGgj2ki8V5RSRVPsCd0aWh3RHukO1J9zBw05e6T-XgUv53YunqHncIqwOzCz2VUMCf3s4g3JZ6ijOUyCR3pQxiSMTdhHgN3esgz6XPPSf2Q-xn4RyGTvHDZA7JTwowfAQIBBOVpBp1yCOgz8BX4EMsSpF7hZkWaWMQ1CIhzdUiL6AW3gJpA1LDkKhcNauLSIocNVG0HefEdRY5RIE5n74V3Ov0ydj99EBOLHGxg2XaAYB79aW6RfQOu0MahEugRetzzXIs8az8Fy42v42SZr9aVwPQfsI2ORR4qRnRz5xBkQSRikbChyLX_lJjNP4-g9fivP7pPbnWP5hOyU1-s86fgXtfJQfMQ_ALczMx8 |
| link.rule.ids | 315,786,790,27955,27956 |
| linkProvider | Oxford University Press |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+genistein+aglycone+on+cancer+and+cancer+risk%3A+a+review+of+in+vitro%2C+preclinical%2C+and+clinical+studies&rft.jtitle=Nutrition+reviews&rft.au=Taylor%2C+Christopher+K&rft.au=Levy%2C+Robert+M&rft.au=Elliott%2C+Jay+C&rft.au=Burnett%2C+Bruce+P&rft.date=2009-07-01&rft.eissn=1753-4887&rft.volume=67&rft.issue=7&rft.spage=398&rft.epage=415&rft_id=info:doi/10.1111%2Fj.1753-4887.2009.00213.x&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0029-6643&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0029-6643&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0029-6643&client=summon |