The effect of genistein aglycone on cancer and cancer risk: a review of in vitro, preclinical, and clinical studies
In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like eff...
Saved in:
Published in | Nutrition reviews Vol. 67; no. 7; pp. 398 - 415 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Blackwell Publishing Inc
01.07.2009
Wiley Oxford University Press |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In Asian epidemiological studies, health benefits, including reduced incidence of breast and prostate cancers, are attributed to soy food and isoflavone consumption. The recent increased intake of soy foods and supplements in the American diet has raised concerns about the possible estrogen‐like effects of natural isoflavones and possible promotion or propagation of estrogen‐sensitive cancers. These concerns are primarily based on in vitro and rodent data which suggest that genistein aglycone can stimulate tumor cell proliferation and growth in mice having deficient immune systems. In contrast, a recent nested case‐control study and meta‐analysis of numerous epidemiological studies show an inverse correlation between genistein intake and breast cancer risk. Furthermore, clinical studies in osteopenic and osteoporotic, postmenopausal women support the breast and uterine safety of purified naturally derived genistein administered for up to 3 years. In this review, we summarize the in vitro, preclinical and clinical evidence for the safety of natural genistein. |
---|---|
Bibliography: | istex:85D20B9C79B763812F148B23381624147C6F5551 ark:/67375/WNG-2WLZF1QK-H ArticleID:NURE213 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0029-6643 1753-4887 |
DOI: | 10.1111/j.1753-4887.2009.00213.x |