A second major histocompatibility complex susceptibility locus for multiple sclerosis

• Published in: Annals of neurology Vol. 61; no. 3; pp. 228 - 236
• Main Authors: Yeo, Tai Wai, De Jager, Philip L., Gregory, Simon G., Barcellos, Lisa F., Walton, Amie, Goris, An, Fenoglio, Chiara, Ban, Maria, Taylor, Craig J., Goodman, Reyna S., Walsh, Emily, Wolfish, Cara S., Horton, Roger, Traherne, James, Beck, Stephan, Trowsdale, John, Caillier, Stacy J., Ivinson, Adrian J., Green, Todd, Pobywajlo, Susan, Lander, Eric S., Pericak-Vance, Margaret A., Haines, Jonathan L., Daly, Mark J., Oksenberg, Jorge R., Hauser, Stephen L., Compston, Alastair, Hafler, David A., Rioux, John D., Sawcer, Stephen
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2007; Willey-Liss
• Subjects: Adult; Biological and medical sciences; Female; Genetic Predisposition to Disease; HLA-D Antigens - genetics; Humans; Immunomodulators; Major Histocompatibility Complex - genetics; Male; Medical sciences; Microsatellite Repeats; Middle Aged; Multiple Sclerosis - genetics; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Original; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide; Multiple sclerosis; Nervous system diseases; Locus; Major histocompatibility system; Central nervous system disease; Inflammatory disease

Objective Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is known to influence susceptibility to multiple sclerosis with the strongest effect originating from the HLA‐DRB1 gene in the class II region. The possibility that other genes in the MHC independently influence sus...