Cortical brain responses during passive nonpainful median nerve stimulation at low frequencies (0.5-4 Hz): An fMRI study

• Published in: Human brain mapping Vol. 28; no. 7; pp. 645 - 653
• Main Authors: Ferretti, Antonio, Babiloni, Claudio, Arienzo, Donatello, Del Gratta, Cosimo, Rossini, Paolo Maria, Tartaro, Armando, Romani, Gian Luca
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2007; Wiley-Liss
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Brain Mapping; Dose-Response Relationship, Radiation; Electric Stimulation - methods; Electrodiagnosis. Electric activity recording; Evoked Potentials, Somatosensory - physiology; Female; functional magnetic resonance imaging (fMRI); Fundamental and applied biological sciences. Psychology; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; Median Nerve - physiology; median nerve electrical stimulation; Medical sciences; Nervous system; Oxygen - blood; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Reaction Time - radiation effects; secondary somatosensory cortex (SII); Somatosensory Cortex - blood supply; Somatosensory Cortex - physiology; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; stimulus frequency; Vertebrates: nervous system and sense organs; Stimulus frequency; median nerve electrical stimulation; Nervous system diseases; Radiodiagnosis; Electrical stimulus; Central nervous system; functional magnetic resonance imaging (fMRI); Low frequency; Nuclear magnetic resonance imaging; Encephalon; Somatosensory cortex; secondary somatosensory cortex (SII); Somesthetic pathway; Median nerve; Functional imaging

Previous findings have shown that the human somatosensory cortical systems that are activated by passive nonpainful electrical stimulation include the contralateral primary somatosensory area (SI), bilateral secondary somatosensory area (SII), and bilateral insula. The present study tested the hypot...