Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

• Published in: Pulmonary circulation Vol. 10; no. 3; pp. 1 - 15
• Main Authors: Wu, Kang, Tang, Haiyang, Lin, Ruizhu, Carr, Shane G., Wang, Ziyi, Babicheva, Aleksandra, Ayon, Ramon J., Jain, Pritesh P., Xiong, Mingmei, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Rahimi, Shayan, Valdez-Jasso, Daniela, Simonson, Tatum S., Desai, Ankit A., Garcia, Joe G.N., Shyy, John Y.-J., Thistlethwaite, Patricia A., Wang, Jian, Makino, Ayako, Yuan, Jason X.-J.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2020; John Wiley & Sons, Inc; Wiley
• Subjects: Cell growth; endothelial cell; Growth factors; platelet‐derived growth factor; platelet‐derived growth factorreceptor; Potassium; Pulmonary hypertension; Smooth muscle; smooth muscle cell; platelet-derived growth factor; smooth muscle cell; platelet-derived growth factorreceptor; endothelial cell

Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to the development and progression of pulmonary va...