Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty in Women Aged 65 and Older: Prospective Findings from the Women's Health Initiative Observational Study
OBJECTIVES: To examine the associations between current use, duration, and potency of angiotensin‐converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline. DESIGN: Data were from the Women's Health Initiative Observational Study (WHI‐OS),...
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| Published in | Journal of the American Geriatrics Society (JAGS) Vol. 57; no. 2; pp. 297 - 303 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.02.2009
Wiley-Blackwell Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0002-8614 1532-5415 1532-5415 |
| DOI | 10.1111/j.1532-5415.2008.02121.x |
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| Abstract | OBJECTIVES: To examine the associations between current use, duration, and potency of angiotensin‐converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.
DESIGN: Data were from the Women's Health Initiative Observational Study (WHI‐OS), a prospective study conducted at 40 U.S. clinical centers.
PARTICIPANTS: Women aged 65 to 79 at baseline who were not frail (N=27,378).
MEASUREMENTS: Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self‐reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self‐reported and physical measurements data at baseline and 3‐year clinic contacts.
RESULTS: By the 3‐year follow‐up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82–1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.
CONCLUSION: Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers. |
|---|---|
| AbstractList | OBJECTIVES:
To examine the associations between current use, duration, and potency of angiotensin‐converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.
DESIGN:
Data were from the Women's Health Initiative Observational Study (WHI‐OS), a prospective study conducted at 40 U.S. clinical centers.
PARTICIPANTS:
Women aged 65 to 79 at baseline who were not frail (N=27,378).
MEASUREMENTS:
Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self‐reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self‐reported and physical measurements data at baseline and 3‐year clinic contacts.
RESULTS:
By the 3‐year follow‐up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82–1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.
CONCLUSION:
Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers. To examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.OBJECTIVESTo examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline.Data were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers.DESIGNData were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers.Women aged 65 to 79 at baseline who were not frail (N=27,378).PARTICIPANTSWomen aged 65 to 79 at baseline who were not frail (N=27,378).Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts.MEASUREMENTSCurrent ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts.By the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.RESULTSBy the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension.Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers.CONCLUSIONOverall, incidence of frailty was similar in current ACE inhibitor users and nonusers. OBJECTIVES: To examine the associations between current use, duration, and potency of angiotensin‐converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline. DESIGN: Data were from the Women's Health Initiative Observational Study (WHI‐OS), a prospective study conducted at 40 U.S. clinical centers. PARTICIPANTS: Women aged 65 to 79 at baseline who were not frail (N=27,378). MEASUREMENTS: Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self‐reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self‐reported and physical measurements data at baseline and 3‐year clinic contacts. RESULTS: By the 3‐year follow‐up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82–1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension. CONCLUSION: Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers. To examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline. Data were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers. Women aged 65 to 79 at baseline who were not frail (N=27,378). Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts. By the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension. Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers. To examine the associations between current use, duration, and potency of angiotensin-converting enzyme (ACE) inhibitors and incident frailty in women aged 65 and older who were not frail at baseline. Data were from the Women's Health Initiative Observational Study (WHI-OS), a prospective study conducted at 40 U.S. clinical centers. Women aged 65 to 79 at baseline who were not frail (N=27,378). Current ACE inhibitor use was ascertained through direct inspection of medicine containers at baseline. Components of frailty were self-reported low physical function or impaired walking, exhaustion, low physical activity, and unintended weight. Frailty was ascertained through self-reported and physical measurements data at baseline and 3-year clinic contacts. By the 3-year follow-up, 3,950 (14.4%) women had developed frailty. Current ACE inhibitor use had no association with incident frailty (multivariate adjusted odds ratio=0.96, 95% confidence interval=0.82-1.13). Duration and potency of ACE inhibitor use were also not significantly associated with incident frailty. A similar pattern of results was observed when incident cardiovascular disease events were studied as a separate outcome or when the sample was restricted to subjects with hypertension. Overall, incidence of frailty was similar in current ACE inhibitor users and nonusers. [PUBLICATION ABSTRACT] |
| Author | Woods, Nancy F. LaCroix, Andrea Z. Black, Henry McDermott, Mary Kooperberg, Charles L. Murray, Anne M. Cochrane, Barbara B. Aragaki, Aaron K. Gray, Shelly L. Rodriguez, Beatriz |
| Author_xml | – sequence: 1 givenname: Shelly L. surname: Gray fullname: Gray, Shelly L. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 2 givenname: Andrea Z. surname: LaCroix fullname: LaCroix, Andrea Z. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 3 givenname: Aaron K. surname: Aragaki fullname: Aragaki, Aaron K. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 4 givenname: Mary surname: McDermott fullname: McDermott, Mary organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 5 givenname: Barbara B. surname: Cochrane fullname: Cochrane, Barbara B. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 6 givenname: Charles L. surname: Kooperberg fullname: Kooperberg, Charles L. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 7 givenname: Anne M. surname: Murray fullname: Murray, Anne M. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 8 givenname: Beatriz surname: Rodriguez fullname: Rodriguez, Beatriz organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 9 givenname: Henry surname: Black fullname: Black, Henry organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington – sequence: 10 givenname: Nancy F. surname: Woods fullname: Woods, Nancy F. organization: From theSchool of Pharmacy, University of Washington, Seattle, Washington†WHI Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, Washington‡Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois§School of Nursing, University of Washington, Seattle, Washington∥Chronic Disease Research Group, Hennepin County Medical Center, Minneapolis, Minnesota#Department of Public Health Sciences, University of Hawaii at Manoa, Honolulu, HawaiiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois††School of Nursing, University of Washington, Seattle, Washington |
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| Notes | ArticleID:JGS2121 ark:/67375/WNG-3DP5WBG6-P istex:02CD9D25FAEA7595FE6F98BDF422AB8E1D622F36 These data were presented in part at the Gerontological Society of America meeting, San Francisco, California, November 16–22, 2007. SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
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| References_xml | – reference: Cao YJ, Mager DE, Simonsick EM et al. Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther 2008;83:422-429. – reference: Sumukadas D, Struthers AD, McMurdo ME. Sarcopenia-a potential target for angiotensin-converting enzyme inhibition? Gerontology 2006;52:237-242. – reference: Peeters AC, Netea MG, Kullberg BJ et al. The effect of renin-angiotensin system inhibitors on pro- and anti-inflammatory cytokine production. Immunology 1998;94:376-379. – reference: Onder G, Liperoti R, Russo A et al. Body mass index, free insulin-like growth factor I, and physical function among older adults: Results from the ilSIRENTE study. Am J Physiol Endocrinol Metab 2006;291:E829-E834. – reference: Penninx BW, Kritchevsky SB, Newman AB et al. Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 2004;52:1105-1113. – reference: Bergman H, Ferrucci L, Guralnik J et al. Frailty: An emerging research and clinical paradigm-issues and controversies. J Gerontol A Biol Sci Med Sci 2007;62A:731-737. – reference: Onder G, Penninx BWJH, Balkrishnan R et al. Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: An observational study. Lancet 2002;359:926-930. – reference: Henriksen EJ, Jacob S. Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition. J Cell Physiol 2003;196:171-179. – reference: Visser M, Pahor M, Taaffe DR et al. Relationship of interleukin-6 and tumor necrosis factor-{alpha} with muscle mass and muscle strength in elderly men and women: The Health ABC Study. J Gerontol A Biol Sci Med Sci 2002;57A:M326-M332. – reference: Maggio M, Ceda GP, Lauretani F et al. Relation of angiotensin-converting enzyme inhibitor treatment to insulin-like growth factor-1 serum levels in subjects >65 years of age (the InCHIANTI study). Am J Cardiol 2006;97:1525-1529. – reference: Gambassi G, Lapane KL, Sgadari A et al. Effects of angiotensin-converting enzyme inhibitors and digoxin on health outcomes of very old patients with heart failure. Arch Intern Med 2000;160:53-60. – reference: Anderson GL, Manson J, Wallace R et al. Implementation of the Women's Health Initiative Study design. Ann Epidemiol 2003;13:S5-S17. – reference: Di Bari M, Van De Poll-Franse LV, Onder G et al. Antihypertensive medications and differences in muscle mass in older persons: The Health, Aging and Body Composition Study. J Am Geriatr Soc 2004;52:961-966. – reference: Kaplan RC, McGinn AP, Pollak MN et al. Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults. J Am Geriatr Soc 2008;56:652-660. – reference: Walston J, Hadley EC, Ferrucci L et al. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006;54:991-1001. – reference: Woods NF, LaCroix AZ, Gray SL et al. Frailty: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005;53:1321-1330. – reference: Schellenbaum GD, Smith NL, Heckbert SR et al. Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension. J Am Geriatr Soc 2005;53:1996-2000. – reference: Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56A:M146-M156. – reference: Cappola AR, Xue QL, Ferrucci L et al. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 2003;88:2019-2025. – reference: Kranzhofer R, Schmidt J, Pfeiffer CAH et al. Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1999;19:1623-1629. – reference: Ainsworth BE, Haskell WL, Leon AS et al. Compendium of physical activities: Classification of energy costs of human physical activities. Med Sci Sports Exerc 1993;25:71-80. – reference: Leng SX, Xue QL, Tian J et al. Inflammation and frailty in older women. J Am Geriatr Soc 2007;55:864-871. – reference: Barzilay JI, Blaum C, Moore T et al. Insulin resistance and inflammation as precursors of frailty: The Cardiovascular Health Study. Arch Intern Med 2007;167:635-641. – reference: Sumukadas D, Witham MD, Struthers AD et al. Effect of perindopril on physical function in elderly people with functional impairment: A randomized controlled trial. Can Med Assoc J 2007;177:867-874. – reference: Manson JE, Greenland P, LaCroix AZ et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002;347:716-725. – reference: Curb JD, Mctiernan A, Heckbert SR et al. Outcomes ascertainment and adjudication methods in the Women's Health Initiative. Ann Epidemiol 2003;13:S122-S128. – reference: Onder G, Liperoti R, Russo A et al. Use of ACE inhibitors is associated with elevated levels of IGFBP-3 among hypertensive older adults: Results from the IlSIRENTE study. Eur J Clin Pharmacol 2007;63:389-395. – reference: Langer RD, White E, Lewis CE et al. The Women's Health Initiative Observational Study: Baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol 2003;13:S107-S121. – reference: Burnam MA, Wells KB, Leake B et al. 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of the Women's Health Initiative Study design publication-title: Ann Epidemiol – volume: 347 start-page: 716 year: 2002 end-page: 725 article-title: Walking compared with vigorous exercise for the prevention of cardiovascular events in women publication-title: N Engl J Med – volume: 54 start-page: 991 year: 2006 end-page: 1001 article-title: Research agenda for frailty in older adults publication-title: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults – volume: 63 start-page: 389 year: 2007 end-page: 395 article-title: Use of ACE inhibitors is associated with elevated levels of IGFBP‐3 among hypertensive older adults publication-title: Results from the IlSIRENTE study – volume: 52 start-page: 1105 year: 2004 end-page: 1113 article-title: Inflammatory markers and incident mobility limitation in the elderly publication-title: J Am Geriatr Soc – volume: 56 start-page: 652 year: 2008 end-page: 660 article-title: Total insulinlike growth factor 1 and insulinlike growth factor binding protein levels, functional status, and mortality in older adults publication-title: J Am Geriatr Soc – volume: 53 start-page: 1321 year: 2005 end-page: 1330 article-title: Frailty publication-title: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study – volume: 19 start-page: 1623 year: 1999 end-page: 1629 article-title: Angiotensin induces inflammatory activation of human vascular smooth muscle cells publication-title: Arterioscler Thromb Vasc Biol – volume: 196 start-page: 171 year: 2003 end-page: 179 article-title: Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition publication-title: J Cell Physiol – volume: 13 start-page: S107 year: 2003 end-page: S121 article-title: The Women's Health Initiative Observational Study publication-title: Baseline characteristics of participants and reliability of baseline measures – volume: 88 start-page: 2019 year: 2003 end-page: 2025 article-title: Insulin‐like growth factor I and interleukin‐6 contribute synergistically to disability and mortality in older women publication-title: J Clin Endocrinol Metab – volume: 55 start-page: 864 year: 2007 end-page: 871 article-title: Inflammation and frailty in older women publication-title: J Am Geriatr Soc – volume: 52 start-page: 237 year: 2006 end-page: 242 article-title: Sarcopenia—a potential target for angiotensin‐converting enzyme inhibition? publication-title: Gerontology – volume: 52 start-page: 1406 year: 2003 end-page: 1412 article-title: Captopril enhanced insulin‐stimulated glycogen synthesis in skeletal muscle but not fatty acid synthesis in adipose tissue of hereditary hypertriglyceridemic rats publication-title: Metabolism – volume: 291 start-page: E829 year: 2006 end-page: E834 article-title: Body mass index, free insulin‐like growth factor I, and physical function among older adults publication-title: Results from the ilSIRENTE study – volume: 167 start-page: 635 year: 2007 end-page: 641 article-title: Insulin resistance and inflammation as precursors of frailty publication-title: The Cardiovascular Health Study – volume: 56 start-page: M146 year: 2001 ident: e_1_2_7_3_2 article-title: Frailty in older adults publication-title: Evidence for a phenotype – ident: e_1_2_7_27_2 doi: 10.1016/j.amjcard.2005.11.089 – ident: e_1_2_7_23_2 doi: 10.1038/sj.clpt.6100303 – ident: e_1_2_7_31_2 doi: 10.1111/j.1532-5415.2007.01637.x – volume: 57 start-page: M326 year: 2002 ident: e_1_2_7_24_2 article-title: Relationship of interleukin‐6 and tumor necrosis factor‐{alpha} with muscle mass and muscle strength in elderly men and women publication-title: The Health ABC Study – ident: e_1_2_7_29_2 doi: 10.1210/jc.2002-021694 – volume: 291 start-page: E829 year: 2006 ident: e_1_2_7_30_2 article-title: Body mass index, free insulin‐like growth factor 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publication-title: A randomized controlled trial – volume: 25 start-page: 71 year: 1993 ident: e_1_2_7_19_2 article-title: Compendium of physical activities publication-title: Classification of energy costs of human physical activities – volume: 54 start-page: 991 year: 2006 ident: e_1_2_7_15_2 article-title: Research agenda for frailty in older adults publication-title: Toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults – volume: 53 start-page: 1321 year: 2005 ident: e_1_2_7_4_2 article-title: Frailty publication-title: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study – ident: e_1_2_7_5_2 doi: 10.1111/j.1532-5415.2004.52308.x – ident: e_1_2_7_13_2 doi: 10.1046/j.1365-2567.1998.00524.x – ident: e_1_2_7_17_2 doi: 10.1056/NEJMoa021067 – ident: e_1_2_7_9_2 doi: 10.1001/archinte.160.1.53 – ident: 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| SubjectTerms | ACE inhibitor use ACE inhibitors Aged Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences disability Drug therapy Female Frail Elderly Frailty General aspects Humans Medical sciences Miscellaneous Mobility Older people Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Women's Health Initiative Womens health |
| Title | Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty in Women Aged 65 and Older: Prospective Findings from the Women's Health Initiative Observational Study |
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