Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 152; no. 2; pp. 570 - 582
• Main Authors: Zhang, Guang-Wei, Gu, Tian-Xiang, Sun, Xue-Jun, Wang, Chunyue, Qi, Xun, Wang, Xiao-Bing, Li-Ling, Jesse
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2016
• Subjects: Cardiothoracic Surgery; edaravone; myocardial infarction; regeneration; stem cell transplantation; ventricular function; CD; BMSC; regeneration; stem cell transplantation; HGF; VEGF; myocardial infarction; ventricular function; edaravone; CXCR4; IGF-1; CX43; bFGF; CSC; PCI; ROS; cTnT; RFP; BrdU; cardiac troponin T; basic fibroblast growth factor; cluster of differentiation; bone marrow mesenchymal stem cell; 5-bromo-2-deoxyuridine; percutaneous coronary intervention; red fluorescent protein; hepatocyte growth factor; CXC chemokine receptor 4; reactive oxygen species; connexin43; cardiac stem cell; vascular endothelial growth factor; insulin-like growth factor 1

To explore the effect of edaravone on bone marrow mesenchymal stem cells (BMSCs) transplanted to treat acute myocardial infarction (AMI) and the underlying mechanism. After pretreatment or treatment with edaravone under conditions of deep hypoxia and serum deprivation, the rat BMSCs were evaluated f...