Neurofilament heavy polypeptide protects against reduction in synaptopodin expression and prevents podocyte detachment

• Published in: Scientific reports Vol. 8; no. 1; pp. 17157 - 14
• Main Authors: Wang, Juan, Hidaka, Teruo, Sasaki, Yu, Tanaka, Eriko, Takagi, Miyuki, Shibata, Terumi, Kubo, Ayano, Trejo, Juan Alejandro Oliva, Wang, Lining, Asanuma, Katsuhiko, Tomino, Yasuhiko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.11.2018; Nature Publishing Group
• Subjects: 38/61; 38/89; 42; 42/34; 631/80/304; 64/60; 692/4022/1585/2759; 82/1; 82/51; 96; 96/109; Biopsy; Extracellular matrix; Glomerulus; Humanities and Social Sciences; Immunofluorescence; Immunoprecipitation; Membranous nephropathy; multidisciplinary; Nephropathy; Polypeptides; Science; Science (multidisciplinary); siRNA; Vinculin; Podocyte Protection; Minimal Change Disease; Podocyte Injury; Focal Segmental Glomerulosclerosis (FSGS); Synaptopodin Expression

Podocytes are highly specialized cells that line the glomerulus of the kidney and play a role in filtration. Podocyte injury plays a critical role in the development of many kidney diseases, but the underlying mechanisms remain unclear. In this study, we identified that neurofilament heavy polypepti...