Oxidative breakage of cellular DNA by plant polyphenols: A putative mechanism for anticancer properties

• Published in: Seminars in cancer biology Vol. 17; no. 5; pp. 370 - 376
• Main Authors: Hadi, S.M., Bhat, Showket H., Azmi, Asfar S., Hanif, Sarmad, Shamim, Uzma, Ullah, M.F.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2007
• Subjects: Anticancer; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Apoptosis; Copper - chemistry; Copper - metabolism; Copper - pharmacology; DNA - drug effects; DNA Breaks; DNA Cleavage; Endogenous copper; Flavonoids - metabolism; Flavonoids - pharmacology; Hematology, Oncology and Palliative Medicine; Humans; Lymphocytes - drug effects; Oxidative Stress; Phenols - metabolism; Phenols - pharmacology; Plant polyphenols; Plants - chemistry; Polyphenols; Prooxidant; Reactive oxygen species (ROS); Prooxidant; Anticancer; Plant polyphenols; Endogenous copper; Reactive oxygen species (ROS); Apoptosis

Plant polyphenols are important components of human diet and a number of them are considered to possess chemopreventive and therapeutic properties against cancer. They are recognized as naturally occurring antioxidants but also act as prooxidants catalyzing DNA degradation in the presence of transit...