Increased Expression of Metalloproteinase-8 and -13 on Articular Cartilage in a Rat Immobilized Knee Model

• Published in: The Tohoku Journal of Experimental Medicine Vol. 217; no. 4; pp. 271 - 278
• Main Authors: Ando, Akira, Hagiwara, Yoshihiro, Tsuchiya, Masahiro, Onoda, Yoshito, Suda, Hideaki, Chimoto, Eiichi, Itoi, Eiji
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2009
• Subjects: Animals; articular cartilage; Cartilage Diseases - enzymology; Cartilage Diseases - pathology; Cartilage, Articular - enzymology; Cartilage, Articular - pathology; Chondrocytes - metabolism; degeneration; Hindlimb; immobilization; Immunohistochemistry; In Situ Hybridization; Male; matrix metalloproteinase; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 8 - genetics; Matrix Metalloproteinase 8 - metabolism; osteoarthritis; Rats; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Time Factors

Joint immobilization is commonly used for the treatment of joint injuries and diseases, but it also causes cartilage degeneration. Damage to the fibrillar meshwork of type II collagen in the articular cartilage is a critical event for cartilage degeneration. Collagenases such as matrix metalloprotei...