miRNA‑490‑3p promotes the metastatic progression of invasive ductal carcinoma

• Published in: Oncology reports Vol. 45; no. 2; pp. 706 - 716
• Main Authors: Lu, Ning, Zhang, Mei, Lu, Lu, Liu, Yan‑Zhao, Zhang, Hai‑Hong, Liu, Xiao‑Dong
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.02.2021; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Animals; Antibodies; Binding sites; Breast - pathology; Breast - surgery; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cancer therapies; Carcinoma, Ductal; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - mortality; Carcinoma, Ductal, Breast - secondary; Carcinoma, Ductal, Breast - surgery; Cell growth; Cell Line, Tumor; Chemotherapy; Comparative analysis; Disease Progression; Disease-Free Survival; DNA-Binding Proteins - genetics; Epithelial-Mesenchymal Transition - genetics; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Instrument industry; Labeling; Lung cancer; Mastectomy; Metastasis; Mice; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - genetics; Plasmids; Protein binding; Proteins; Reagents; RNA-Binding Proteins - genetics; Scientific equipment and supplies industry; Transforming growth factors; Xenograft Model Antitumor Assays; United States; China; miR‑490‑3p; epithelial‑to‑mesenchymal transition; breast cancer; poly r(C) binding protein 1

MicroRNA (miRNA/mir)‑490‑3p has been defined as a tumor suppressor in different types of cancer, including breast cancer. However, miR‑490‑3p has been shown to function as a tumor suppressor and promoter in a context‑dependent manner in hepatocellular and lung cancer. Contrary to previous studies, t...