Cx26 regulates proliferation of repairing basal airway epithelial cells

• Published in: The international journal of biochemistry & cell biology Vol. 52; pp. 152 - 160
• Main Authors: Crespin, S., Bacchetta, M., Bou Saab, J., Tantilipikorn, P., Bellec, J., Dudez, T., Nguyen, T.H., Kwak, B.R., Lacroix, J.S., Huang, S., Wiszniewski, L., Chanson, M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.07.2014; Elsevier
• Subjects: Airways; Biology; Bronchi - metabolism; Bronchi - pathology; Cell Differentiation - physiology; Cell Proliferation - physiology; Cells, Cultured; Connexin 26; Connexins - metabolism; Cx26; Cystic fibrosis; Cystic Fibrosis - metabolism; Cystic Fibrosis - pathology; Epithelial Cells - metabolism; Epithelial Cells - pathology; Epithelium; Gap junctions; Human health and pathology; Humans; Injuries; Kruppel-Like Transcription Factors - metabolism; Life Sciences; Maintenance; Mucilair; Proliferation; Regulators; Repair; Repairing; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Mucilair; Cx26; Cystic fibrosis; Proliferation; Repair; Gap junctions

•Repair of human airway epithelial cells from control individuals and patients with cystic fibrosis (CF) in response to injury is investigated.•Connexin26, a gap junction protein, is transiently induced in a subpopulation of basal airway epithelial cells expressing keratin14.•Connexin26 is induced b...