Clostridium ramosum regulates enterochromaffin cell development and serotonin release

• Published in: Scientific reports Vol. 9; no. 1; p. 1177
• Main Authors: Mandić, Ana D., Woting, Anni, Jaenicke, Tina, Sander, Anika, Sabrowski, Wiebke, Rolle-Kampcyk, Ulrike, von Bergen, Martin, Blaut, Michael
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2019; Nature Publishing Group
• Subjects: 13; 13/1; 13/100; 13/106; 38; 38/77; 631/326/41/2533; 631/532/1360; Absorption; Cell lines; Clostridium; Digestive system; Enteric nervous system; Gastrointestinal tract; Germfree; High fat diet; Humanities and Social Sciences; Information systems; Intestinal microflora; Intestine; Microbiota; multidisciplinary; Nervous system; Obesity; Organoids; Science; Science (multidisciplinary); Secretion; Serotonin

Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the...