Clostridium ramosum regulates enterochromaffin cell development and serotonin release

Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the...

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Published in	Scientific reports Vol. 9; no. 1; p. 1177
Main Authors	Mandić, Ana D., Woting, Anni, Jaenicke, Tina, Sander, Anika, Sabrowski, Wiebke, Rolle-Kampcyk, Ulrike, von Bergen, Martin, Blaut, Michael
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 04.02.2019 Nature Publishing Group
Subjects	13 13/1 13/100 13/106 38 38/77 631/326/41/2533 631/532/1360 Absorption Cell lines Clostridium Digestive system Enteric nervous system Gastrointestinal tract Germfree High fat diet Humanities and Social Sciences Information systems Intestinal microflora Intestine Microbiota multidisciplinary Nervous system Obesity Organoids Science Science (multidisciplinary) Secretion Serotonin
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Abstract	Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C . ramosum , intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro , suggesting that the presence of C . ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity.
AbstractList	Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C . ramosum , intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro , suggesting that the presence of C . ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity. Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C. ramosum, intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro, suggesting that the presence of C. ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity. Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C. ramosum, intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro, suggesting that the presence of C. ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity.Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of peristaltic of the gut, epithelial secretion and promotes the development and maintenance of the enteric neurons. Recent studies showed that the indigenous gut microbiota modulates 5-HT signalling and that ECs use sensory receptors to detect dietary and microbiota-derived signals from the lumen to subsequently transduce the information to the nervous system. We hypothesized that Clostridium ramosum by increasing gut 5-HT availability consequently contributes to high-fat diet-induced obesity. Using germ-free mice and mice monoassociated with C. ramosum, intestinal cell lines and mouse organoids, we demonstrated that bacterial cell components stimulate host 5-HT secretion and program the differentiation of colonic intestinal stem progenitors toward the secretory 5-HT-producing lineage. An elevated 5-HT level regulates the expression of major proteins involved in intestinal fatty acid absorption in vitro, suggesting that the presence of C. ramosum in the gut promotes 5-HT secretion and thereby could facilitates intestinal lipid absorption and the development of obesity.
ArticleNumber	1177
Author	Rolle-Kampcyk, Ulrike Mandić, Ana D. Jaenicke, Tina von Bergen, Martin Sander, Anika Blaut, Michael Woting, Anni Sabrowski, Wiebke
Author_xml	– sequence: 1 givenname: Ana D. surname: Mandić fullname: Mandić, Ana D. email: ana.mandic@dife.de organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – sequence: 2 givenname: Anni surname: Woting fullname: Woting, Anni organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – sequence: 3 givenname: Tina surname: Jaenicke fullname: Jaenicke, Tina organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – sequence: 4 givenname: Anika surname: Sander fullname: Sander, Anika organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – sequence: 5 givenname: Wiebke surname: Sabrowski fullname: Sabrowski, Wiebke organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke – sequence: 6 givenname: Ulrike surname: Rolle-Kampcyk fullname: Rolle-Kampcyk, Ulrike organization: Department of Molecular Systems Biology, Helmholtz Centre for Enviromental Research –UFZ – sequence: 7 givenname: Martin surname: von Bergen fullname: von Bergen, Martin organization: Department of Molecular Systems Biology, Helmholtz Centre for Enviromental Research –UFZ, Institute of Biochemistry, Faculty of Life Sciences, University of Leipzig – sequence: 8 givenname: Michael surname: Blaut fullname: Blaut, Michael organization: Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30718836$$D View this record in MEDLINE/PubMed
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Snippet	Peripheral serotonin (5-hydroxytryptamine: 5-HT) synthesized in the intestine by enterochromaffin cells (ECs), plays an important role in the regulation of...
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SubjectTerms	13 13/1 13/100 13/106 38 38/77 631/326/41/2533 631/532/1360 Absorption Cell lines Clostridium Digestive system Enteric nervous system Gastrointestinal tract Germfree High fat diet Humanities and Social Sciences Information systems Intestinal microflora Intestine Microbiota multidisciplinary Nervous system Obesity Organoids Science Science (multidisciplinary) Secretion Serotonin
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Title	Clostridium ramosum regulates enterochromaffin cell development and serotonin release
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