MicroRNA Expression Profile Identifies High Grade, Non-Muscle-Invasive Bladder Tumors at Elevated Risk to Progress to an Invasive Phenotype

• Published in: Genes Vol. 8; no. 2; p. 77
• Main Authors: Lenherr, Sara M, Tsai, Sheaumei, Silva Neto, Brasil, Sullivan, Travis B, Cimmino, Cara B, Logvinenko, Tanya, Gee, Jason, Huang, Wei, Libertino, John A, Summerhayes, Ian C, Rieger-Christ, Kimberly M
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.02.2017; MDPI
• Subjects: Bladder; intravesical therapy; Mesenchyme; microRNA; miRNA; non-muscle invasive bladder cancer; Paraffin; Polymerase chain reaction; progression; Ribonucleic acid; RNA; Tumors; Urinary bladder; Urothelial carcinoma; microRNA; non-muscle invasive bladder cancer; progression; intravesical therapy

The objective of this study was to identify a panel of microRNAs (miRNAs) differentially expressed in high-grade non-muscle invasive (NMI; TaG3-T1G3) urothelial carcinoma that progress to muscle-invasive disease compared to those that remain non-muscle invasive, whether recurrence happens or not. Ei...