Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology

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Published inClinical Microbiology Reviews Vol. 23; no. 1; pp. 74 - 98
Main Authors TREGONING, John S, SCHWARZE, Jürgen
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.01.2010
American Society for Microbiology (ASM)
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Abstract Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CMR About CMR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CMR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0893-8512 Online ISSN: 1098-6618 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CMR .asm.org, visit: CMR       
AbstractList In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy, in particular, is a time of increased disease susceptibility and severity. Early-life viral infection causes acute illness and can be associated with the development of wheezing and asthma in later life. The most commonly detected viruses are respiratory syncytial virus (RSV), rhinovirus (RV), and influenza virus. In this review we explore the complete picture from epidemiology and virology to clinical impact and immunology. Three striking aspects emerge. The first is the degree of similarity: although the infecting viruses are all different, the clinical outcome, viral evasion strategies, immune response, and long-term sequelae share many common features. The second is the interplay between the infant immune system and viral infection: the immaturity of the infant immune system alters the outcome of viral infection, but at the same time, viral infection shapes the development of the infant immune system and its future responses. Finally, both the virus and the immune response contribute to damage to the lungs and subsequent disease, and therefore, any prevention or treatment needs to address both of these factors.
Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue CMR About CMR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy CMR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0893-8512 Online ISSN: 1098-6618 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to CMR .asm.org, visit: CMR       
Author John S. Tregoning
Jürgen Schwarze
AuthorAffiliation Centre for Infection, Department of Cellular and Molecular Medicine, St. George's University of London, London SW17 0RE, United Kingdom, 1 Child Life and Health and Centre for Inflammation Research, the University of Edinburgh, the Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom 2
AuthorAffiliation_xml – name: Centre for Infection, Department of Cellular and Molecular Medicine, St. George's University of London, London SW17 0RE, United Kingdom, 1 Child Life and Health and Centre for Inflammation Research, the University of Edinburgh, the Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom 2
Author_xml – sequence: 1
  givenname: John S
  surname: TREGONING
  fullname: TREGONING, John S
  organization: Centre for Infection, Department of Cellular and Molecular Medicine, St. George's University of London, London SW17 0RE, United Kingdom
– sequence: 2
  givenname: Jürgen
  surname: SCHWARZE
  fullname: SCHWARZE, Jürgen
  organization: Child Life and Health and Centre for Inflammation Research, the University of Edinburgh, the Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22351755$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/20065326$$D View this record in MEDLINE/PubMed
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In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy, in particular, is a time of increased disease susceptibility...
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StartPage 74
SubjectTerms Biological and medical sciences
Child, Preschool
Fundamental and applied biological sciences. Psychology
Humans
Infant
Infant, Newborn
Infectious diseases
Influenza virus
Medical sciences
Microbiology
Respiratory syncytial virus
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - immunology
Respiratory Tract Infections - pathology
Respiratory Tract Infections - virology
Reviews
Rhinovirus
Virus Diseases - epidemiology
Virus Diseases - immunology
Virus Diseases - pathology
Virus Diseases - virology
Viruses - immunology
Viruses - isolation & purification
Viruses - pathogenicity
Title Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
URI http://cmr.asm.org/content/23/1/74.abstract
https://www.ncbi.nlm.nih.gov/pubmed/20065326
https://search.proquest.com/docview/21292242
https://search.proquest.com/docview/734233171
https://pubmed.ncbi.nlm.nih.gov/PMC2806659
Volume 23
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