Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity - Bulut, Haydar; Hattori, Shin-ichiro; Aoki-Ogata, Hiromi; Hayashi, Hironori; Das, Debananda; Aoki, Manabu; Davis, David A.; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R.; Ghosh, Arun K.; Mitsuya, Hiroaki (Scientific reports, 2020)
Keywords: 631/154; 631/535; 631/92; Adaptation; Amino acids; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Benzene; Cell Line; Cell permeability; Darunavir - pharmacology; Drug Resistance, Viral - drug effects; Fluorine; HIV; HIV Infections - drug therapy; HIV Protease - metabolism; HIV Protease Inhibitors - pharmacology; HIV-1 - drug effects; Human immunodeficiency virus; Humanities and Social Sciences; Humans; multidisciplinary; Plasticity; Proteinase inhibitors; Science; Science (multidisciplinary); Sulfur; Virus Replication - drug effects