Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls
Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of dopaminergic, GABAergic, glutamatergic, and serotoninergic neurotransmitters in first-episode psychosis (FEP) patients (n = 166), unaffected...
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Published in | Scientific reports Vol. 10; no. 1; pp. 21423 - 11 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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London
Nature Publishing Group UK
08.12.2020
Nature Publishing Group Nature Portfolio |
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Abstract | Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of dopaminergic, GABAergic, glutamatergic, and serotoninergic neurotransmitters in first-episode psychosis (FEP) patients (n = 166), unaffected siblings (n = 76), and community-based controls (n = 166) included in a cross-sectional study. Plasma levels of glutamic acid (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantified by gas-chromatography-mass spectrometry. We used the generalized linear model adjusted by sex, age, and body mass index for group comparison and paired t-test for FEP-Sibling pairs. FEP had reduced GABA plasma levels compared to siblings and controls (p < 0.05 for both). Siblings had lower GLU, Glx and PRO (p < 0.05 for all) but increased TRP compared to patients and controls (p < 0.05 for both). FEP patients with longer duration of pharmacological treatment and medicated only with antipsychotics had increased GLU compared to FEP with shorter periods, or with those treated with a combination of medications (p < 0.05 for both). Finally, FEP patients treated only with antipsychotics presented higher Glx compared to those with mixed medications (p = 0.026). Our study suggests that FEP have low a GABA plasma profile. Unaffected siblings may be a possible risk group for metabolic abnormalities. |
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AbstractList | Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of dopaminergic, GABAergic, glutamatergic, and serotoninergic neurotransmitters in first-episode psychosis (FEP) patients (n = 166), unaffected siblings (n = 76), and community-based controls (n = 166) included in a cross-sectional study. Plasma levels of glutamic acid (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantified by gas-chromatography-mass spectrometry. We used the generalized linear model adjusted by sex, age, and body mass index for group comparison and paired t-test for FEP-Sibling pairs. FEP had reduced GABA plasma levels compared to siblings and controls (p < 0.05 for both). Siblings had lower GLU, Glx and PRO (p < 0.05 for all) but increased TRP compared to patients and controls (p < 0.05 for both). FEP patients with longer duration of pharmacological treatment and medicated only with antipsychotics had increased GLU compared to FEP with shorter periods, or with those treated with a combination of medications (p < 0.05 for both). Finally, FEP patients treated only with antipsychotics presented higher Glx compared to those with mixed medications (p = 0.026). Our study suggests that FEP have low a GABA plasma profile. Unaffected siblings may be a possible risk group for metabolic abnormalities. Abstract Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of dopaminergic, GABAergic, glutamatergic, and serotoninergic neurotransmitters in first-episode psychosis (FEP) patients (n = 166), unaffected siblings (n = 76), and community-based controls (n = 166) included in a cross-sectional study. Plasma levels of glutamic acid (GLU), glutamine, glycine, proline (PRO), tryptophan (TRP), tyrosine, serine and GABA were quantified by gas-chromatography-mass spectrometry. We used the generalized linear model adjusted by sex, age, and body mass index for group comparison and paired t-test for FEP-Sibling pairs. FEP had reduced GABA plasma levels compared to siblings and controls (p < 0.05 for both). Siblings had lower GLU, Glx and PRO (p < 0.05 for all) but increased TRP compared to patients and controls (p < 0.05 for both). FEP patients with longer duration of pharmacological treatment and medicated only with antipsychotics had increased GLU compared to FEP with shorter periods, or with those treated with a combination of medications (p < 0.05 for both). Finally, FEP patients treated only with antipsychotics presented higher Glx compared to those with mixed medications (p = 0.026). Our study suggests that FEP have low a GABA plasma profile. Unaffected siblings may be a possible risk group for metabolic abnormalities. |
ArticleNumber | 21423 |
Author | Shuhama, Rosana Fachim, Helene Aparecida Jordão, Alceu Afonso da Roza, Daiane Leite Loureiro, Camila Marcelino Del-Ben, Cristina Marta Menezes, Paulo Rossi Louzada-Junior, Paulo Corsi-Zuelli, Fabiana Deminice, Rafael Simões-Ambrosio, Lívia Maria Cordeiro |
Author_xml | – sequence: 1 givenname: Camila Marcelino surname: Loureiro fullname: Loureiro, Camila Marcelino email: camila.loureiro@usp.br organization: Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Population Mental Health Research Centre, Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo – sequence: 2 givenname: Daiane Leite surname: da Roza fullname: da Roza, Daiane Leite organization: Division of Psychiatry, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo – sequence: 3 givenname: Fabiana surname: Corsi-Zuelli fullname: Corsi-Zuelli, Fabiana organization: Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Division of Psychiatry, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo – sequence: 4 givenname: Rosana surname: Shuhama fullname: Shuhama, Rosana organization: Population Mental Health Research Centre, Division of Psychiatry, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo – sequence: 5 givenname: Helene Aparecida surname: Fachim fullname: Fachim, Helene Aparecida organization: Department of Endocrinology and Metabolism, Salford Royal Foundation Trust – sequence: 6 givenname: Lívia Maria Cordeiro surname: Simões-Ambrosio fullname: Simões-Ambrosio, Lívia Maria Cordeiro organization: Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo – sequence: 7 givenname: Rafael surname: Deminice fullname: Deminice, Rafael organization: Department of Physical Education, State University of Londrina – sequence: 8 givenname: Alceu Afonso surname: Jordão fullname: Jordão, Alceu Afonso organization: Division of Nutrition and Metabolism, Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo – sequence: 9 givenname: Paulo Rossi surname: Menezes fullname: Menezes, Paulo Rossi organization: Population Mental Health Research Centre, Department of Preventive Medicine, Faculty of Medicine, University of São Paulo – sequence: 10 givenname: Cristina Marta surname: Del-Ben fullname: Del-Ben, Cristina Marta organization: Population Mental Health Research Centre, Division of Psychiatry, Department of Neurosciences and Behaviour, Ribeirão Preto Medical School, University of São Paulo – sequence: 11 givenname: Paulo surname: Louzada-Junior fullname: Louzada-Junior, Paulo organization: Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33293633$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_3390_nu13113875 crossref_primary_10_1080_15622975_2023_2271965 crossref_primary_10_1111_nmo_14596 crossref_primary_10_1016_j_ejpsy_2023_100229 crossref_primary_10_1016_j_schres_2021_11_011 crossref_primary_10_1186_s12888_023_04784_y crossref_primary_10_3389_fpsyt_2024_1408175 |
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Snippet | Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the co-activation of... Abstract Investigations of plasma amino acids in early psychosis and their unaffected siblings are rare. We measured plasma amino acids involved in the... |
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Title | Plasma amino acids profile in first-episode psychosis, unaffected siblings and community-based controls |
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