Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics

• Published in: Scientific reports Vol. 11; no. 1; pp. 10309 - 10
• Main Authors: McCarthy, James M., Virdee, Jasmeet, Brown, Jessica, Ursu, Daniel, Ahmed, Zeshan, Cavallini, Annalisa, Nuthall, Hugh N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.05.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/154/1435; 631/154/556; 631/378/1689; 631/378/87; 631/80/304; Alzheimer's disease; Brain slice preparation; Cell culture; Conformation; Explants; Hippocampus; Humanities and Social Sciences; Localization; multidisciplinary; Neurodegeneration; Neurodegenerative diseases; Paralysis; Progressive supranuclear palsy; Propagation; Science; Science (multidisciplinary); Synapses; Tau protein

Intracellular tau inclusions are a pathological hallmark of Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration and other sporadic neurodegenerative tauopathies. Recent in vitro and in vivo studies have shown that tau aggregates may spread to neighbouring cells and fu...