EGFR Signaling in Liver Diseases

• Published in: International Journal of Molecular Sciences Vol. 17; no. 1; p. 30
• Main Authors: Komposch, Karin, Sibilia, Maria
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 29.12.2015; MDPI
• Subjects: Animals; Cell Transformation, Neoplastic - metabolism; EGFR; Epidermal growth factor; ErbB Receptors; hepatocellular carcinoma; Humans; Kinases; Ligands; liver; Liver diseases; Liver Diseases - metabolism; Liver Diseases - physiopathology; Liver Regeneration; Membranes; Mice; partial hepatectomy; Review; Signal Transduction; partial hepatectomy; liver; EGFR; hepatocellular carcinoma

The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase that is activated by several ligands leading to the activation of diverse signaling pathways controlling mainly proliferation, differentiation, and survival. The EGFR signaling axis has been shown to play a key r...