Fetal Hippocampal Grafts Containing CA3 Cells Restore Host Hippocampal Glutamate Decarboxylase-Positive Interneuron Numbers in a Rat Model of Temporal Lobe Epilepsy

• Published in: The Journal of neuroscience Vol. 20; no. 23; pp. 8788 - 8801
• Main Authors: Shetty, Ashok K, Turner, Dennis A
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 01.12.2000; Society for Neuroscience
• Subjects: Animals; Brain Tissue Transplantation; Cell Count; Cell Size; Dentate Gyrus - drug effects; Dentate Gyrus - pathology; Disease Models, Animal; Epilepsy, Temporal Lobe - chemically induced; Epilepsy, Temporal Lobe - surgery; Epilepsy, Temporal Lobe - therapy; Fetal Tissue Transplantation; Glutamate Decarboxylase - metabolism; Graft Survival; Hippocampus - enzymology; Hippocampus - pathology; Hippocampus - surgery; Hippocampus - transplantation; Immunohistochemistry; Injections, Intraventricular; Interneurons - cytology; Interneurons - pathology; Interneurons - transplantation; Isoenzymes - metabolism; Kainic Acid; Male; Rats; Rats, Inbred F344

Degeneration of CA3-pyramidal neurons in hippocampus after intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, results in hyperexcitability within both dentate gyrus and the CA1 subfield. It also leads to persistent reductions in hippocampal glutamate decarbox...