Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

• Published in: Cell host & microbe Vol. 27; no. 6; pp. 870 - 878
• Main Authors: Park, Annsea, Iwasaki, Akiko
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.06.2020
• Subjects: Animals; Antiviral Agents - pharmacology; Betacoronavirus - physiology; Coronavirus Infections - drug therapy; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronavirus Infections - virology; COVID-19; Humans; Immune Evasion; Interferon Lambda; Interferon Type I - genetics; Interferon Type I - immunology; Interferon Type I - pharmacology; Interferons - genetics; Interferons - immunology; Interferons - pharmacology; Pandemics; Pneumonia, Viral - drug therapy; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Recombinant Proteins - pharmacology; SARS-CoV-2; Signal Transduction

Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics or vaccines to this ongoing global threat, type I and type III interferons (IFNs) are currently being evaluated for their efficacy....