Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics

• Published in: The Journal of neuroscience Vol. 13; no. 1; pp. 181 - 194
• Main Authors: Delcour, AH, Lipscombe, D, Tsien, RW
• Format: Journal Article
• Language: English
• Published: Washington, DC Soc Neuroscience 01.01.1993; Society for Neuroscience
• Subjects: Animals; Biological and medical sciences; Calcium Channels - metabolism; Calcium Channels - physiology; Cells, Cultured; Computer Simulation; Electrophysiology; Fundamental and applied biological sciences. Psychology; Ion Channel Gating; Kinetics; Monte Carlo Method; Neurons - metabolism; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Rana; Rana catesbeiana; Sympathetic Nervous System - cytology; Sympathetic Nervous System - metabolism; Vertebrates: nervous system and sense organs; Vertebrata; Calcium; Autonomic nervous system; Frog; Amphibia; Electrophysiology; Patch clamp method; Salientia; Ionic channel; Rana catesbeiana; Sympathic nervous system

In many neurons, N-type Ca2+ channels are a major Ca2+ entry pathway and strongly influence neurotransmitter release. We carried out cell- attached patch recordings (110 mM Ba2+ as charge carrier) to characterize the rapid opening and closing kinetics of N-type Ca2+ channel gating in frog sympatheti...