Mitochondrial fusion is essential for steroid biosynthesis

• Published in: PloS one Vol. 7; no. 9; p. e45829
• Main Authors: Duarte, Alejandra, Poderoso, Cecilia, Cooke, Mariana, Soria, Gastón, Cornejo Maciel, Fabiana, Gottifredi, Vanesa, Podestá, Ernesto J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.09.2012; Public Library of Science (PLoS)
• Subjects: Adrenal glands; Animals; Biological activity; Biology; Biosynthesis; Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology; Cell Line; Chorionic Gonadotropin - pharmacology; Chorionic Gonadotropin - physiology; Cyclic AMP - pharmacology; Cyclic AMP - physiology; Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Epidermal Growth Factor - pharmacology; Epidermal Growth Factor - physiology; Extracellular signal-regulated kinase; Extracellular Signal-Regulated MAP Kinases - metabolism; Fusion protein; Gene Expression Regulation; Gene Knockdown Techniques; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; GTP Phosphohydrolases - physiology; Hormones; Humans; Isoquinolines - pharmacology; Kinases; Kinetics; Leydig Cells - metabolism; Localization; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - physiology; Mitochondrial DNA; Mitochondrial Dynamics; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mitochondrial Proteins - physiology; Organelle Shape; Organelles; Progesterone - biosynthesis; Protein kinase A; Protein Transport; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism; Proton Ionophores - pharmacology; RNA Interference; Rodents; Steroidogenesis; Stimulation; Sulfonamides - pharmacology; Argentina

Although the contribution of mitochondrial dynamics (a balance in fusion/fission events and changes in mitochondria subcellular distribution) to key biological process has been reported, the contribution of changes in mitochondrial fusion to achieve efficient steroid production has never been explor...