AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group - Zhong, Linlin; Shen, Honglin; Huang, Chenfei; Jing, Hongwu; Cao, Deliang (Toxicology and applied pharmacology, 2011)
Keywords: 60 APPLIED LIFE SCIENCES; alcohols; Aldehyde Reductase - physiology; Aldo-keto reductase family 1 member B10; Aldo-Keto Reductases; Anthracyclines; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; Antibiotics, Antineoplastic - pharmacology; ANTINEOPLASTIC DRUGS; Biological and medical sciences; BODY; CARCINOMAS; catalytic activity; CELL CULTURES; Cells, Cultured; CHROMATOGRAPHY; Daunorubicin - metabolism; Daunorubicin - pharmacology; DIGESTIVE SYSTEM; DISEASES; DOXORUBICIN; Drug metabolism; Drug resistance; Drug Resistance, Neoplasm; DRUGS; EMISSION; ENZYME ACTIVITY; Enzyme kinetics; ENZYMES; epirubicin; FLUORESCENCE; GLANDS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; Humans; idarubicin; Idarubicin - metabolism; Idarubicin - pharmacology; IMMUNE SYSTEM DISEASES; IN VITRO; IONIZATION; Ketones - chemistry; LEUKEMIA; LIQUID COLUMN CHROMATOGRAPHY; LIVER; LUMINESCENCE; lung neoplasms; LUNGS; lymphoma; LYMPHOMAS; MAMMARY GLANDS; MASS SPECTROSCOPY; Medical sciences; METABOLISM; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; Oxidation-Reduction; PHOTON EMISSION; PROTEINS; recombinant proteins; RESPIRATORY SYSTEM; SEPARATION PROCESSES; SPECTROSCOPY; SUBSTRATES; Toxicology; vector control; Aldo-keto reductase family 1 member B10; Anthracyclines; AKR1B10; 4-HNE; LC–MS; Drug metabolism; ESI; EGFP; MTT; Drug resistance; Enzyme kinetics; HPLC; Antineoplastic agent; Drug; Treatment resistance; Enzyme; Metabolism; In vitro; Antibiotic; Daunorubicin; Anthracyclins; Idarubicin; Oxidoreductases; Kinetics; Reductase