Optogenetic Peripheral Nerve Immunogenicity

• Published in: Scientific reports Vol. 8; no. 1; pp. 14076 - 17
• Main Authors: Maimon, Benjamin E., Diaz, Maurizio, Revol, Emilie C. M., Schneider, Alexis M., Leaker, Ben, Varela, Claudia E., Srinivasan, Shriya, Weber, Matthew B., Herr, Hugh M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.09.2018; Nature Publishing Group
• Subjects: 13/109; 13/51; 45/77; 631/378/1959/2605; 631/378/371; 631/61/201; 692/617/375; 96/31; Antibodies; Atrophy; Cell death; Central nervous system; Clinical trials; Computer engineering; Cytotoxicity; FDA approval; Genetics; Health sciences; Humanities and Social Sciences; Immunogenicity; Immunosuppression; Information processing; multidisciplinary; Opsins; Optics; Peroneal nerve; RAG2 protein; Retinitis; Retinitis pigmentosa; Science; Science (multidisciplinary); Spinal cord; Tacrolimus; Blood-spinal Cord Barrier (BSCB); Placebo Rate; American Research Products; Nerve Expression; Optogenetic Activation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-32075-0

Optogenetic technologies have been the subject of great excitement within the scientific community for their ability to demystify complex neurophysiological pathways in the central (CNS) and peripheral nervous systems (PNS). The excitement surrounding optogenetics has also extended to the clinic wit...