Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2

• Published in: Gynecologic oncology Vol. 137; no. 1; pp. 86 - 92
• Main Authors: Minion, Lindsey E., Dolinsky, Jill S., Chase, Dana M., Dunlop, Charles L., Chao, Elizabeth C., Monk, Bradley J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: Adult; Aged; Aged, 80 and over; Ataxia Telangiectasia Mutated Proteins - genetics; BRCA1; BRCA2; Breast Neoplasms - genetics; Checkpoint Kinase 2 - genetics; Cohort Studies; DNA-Binding Proteins - genetics; Fanconi Anemia Complementation Group Proteins; Female; Genes, BRCA1; Genes, BRCA2; Genes, p53; Genetic Predisposition to Disease; Genetic Testing; Hematology, Oncology and Palliative Medicine; Hereditary; Humans; Lynch syndrome; Middle Aged; Multi-gene; Mutation; Next-generation sequencing; Obstetrics and Gynecology; Ovarian Neoplasms - genetics; RNA Helicases - genetics; Young Adult; Next-generation sequencing; BRCA1; Hereditary; BRCA2; Multi-gene; Lynch syndrome
• ISSN: 0090-8258; 1095-6859; 1095-6859
• DOI: 10.1016/j.ygyno.2015.01.537

Genetic predisposition to ovarian cancer is well documented. With the advent of next generation sequencing, hereditary panel testing provides an efficient method for evaluating multiple genes simultaneously. Therefore, we sought to investigate the contribution of 19 genes identified in the literatur...