Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome

• Published in: Scientific reports Vol. 8; no. 1; pp. 11424 - 19
• Main Authors: Fung, Jenny N., Mortlock, Sally, Girling, Jane E., Holdsworth-Carson, Sarah J., Teh, Wan Tinn, Zhu, Zhihong, Lukowski, Samuel W., McKinnon, Brett D., McRae, Allan, Yang, Jian, Healey, Martin, Powell, Joseph E., Rogers, Peter A. W., Montgomery, Grant W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.07.2018; Nature Publishing Group
• Subjects: 38; 38/39; 45; 45/61; 631/114/2407; 631/208/200; Biological control; Chromosome 1; Chromosome 12; DNA probes; Endometriosis; Endometrium; Gene expression; Gene mapping; Gene silencing; Genetic control; Genetic effects; Genotype & phenotype; Health risks; Humanities and Social Sciences; Menstrual cycle; multidisciplinary; Polycystic ovary syndrome; Probes; Quantitative trait loci; Science; Science (multidisciplinary)

Gene expression varies markedly across the menstrual cycle and expression levels for many genes are under genetic control. We analyzed gene expression and mapped expression quantitative trait loci (eQTLs) in endometrial tissue samples from 229 women and then analyzed the overlap of endometrial eQTL...