Vitamin D ameliorates adipose browning in chronic kidney disease cachexia

• Published in: Scientific reports Vol. 10; no. 1; pp. 14175 - 15
• Main Authors: Cheung, Wai W., Ding, Wei, Hoffman, Hal M., Wang, Zhen, Hao, Sheng, Zheng, Ronghao, Gonzalez, Alex, Zhan, Jian-Ying, Zhou, Ping, Li, Shiping, Esparza, Mary C., Lieber, Richard L., Mak, Robert H.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.08.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 692/4022; 692/4022/272; Adipocytes, Beige - drug effects; Adipocytes, Beige - metabolism; Adipocytes, Brown - metabolism; Adipocytes, White - metabolism; Adipose tissue; Animals; Appetite; Cachexia; Cachexia - drug therapy; Cachexia - etiology; Cachexia - physiopathology; Calcifediol - blood; Calcifediol - deficiency; Calcifediol - pharmacology; Calcifediol - therapeutic use; Calcitriol; Calcitriol - blood; Calcitriol - deficiency; Calcitriol - pharmacology; Calcitriol - therapeutic use; Collagen; Disease Models, Animal; Eating - drug effects; Fibrosis; Fibrosis - genetics; Gastrocnemius muscle; Gene Expression Regulation - drug effects; Hand Strength; Humanities and Social Sciences; Kidney diseases; Kidneys; Mice; Mice, Inbred C57BL; multidisciplinary; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - pathology; Musculoskeletal system; Nephrectomy; Parathyroid Hormone - blood; Regeneration; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - drug therapy; RNA, Messenger - biosynthesis; Rotarod Performance Test; Science; Science (multidisciplinary); Sequence Analysis, RNA; Skeletal muscle; Supplements; Thermogenesis; Thermogenesis - drug effects; Vitamin D; Weight Gain - drug effects

Patients with chronic kidney disease (CKD) are often 25(OH)D 3 and 1,25(OH) 2 D 3 insufficient. We studied whether vitamin D repletion could correct aberrant adipose tissue and muscle metabolism in a mouse model of CKD-associated cachexia. Intraperitoneal administration of 25(OH)D 3 and 1,25(OH) 2 D...