Venous thromboembolism during pregnancy or postpartum: findings from the RIETE Registry
Venous thromboembolism (VTE) occurs infrequently during pregnancy, and issues concerning its natural history, prevention and therapy remain unresolved. RIETE is an ongoing registry of consecutive patients with objectively confirmed, symptomatic acute VTE. In this analysis, we compared the clinical c...
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Published in | Thrombosis and haemostasis Vol. 97; no. 2; p. 186 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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01.02.2007
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Abstract | Venous thromboembolism (VTE) occurs infrequently during pregnancy, and issues concerning its natural history, prevention and therapy remain unresolved. RIETE is an ongoing registry of consecutive patients with objectively confirmed, symptomatic acute VTE. In this analysis, we compared the clinical characteristics and outcome for all enrolled pregnant and postpartum women with acute VTE, and all non-pregnant women in the same age range. Up to May 2005, 11,630 patients were enrolled in RIETE, of whom 848 (7.3%) were women aged <47 years. Of them, 72 (8.5%) were pregnant, 64 (7.5%) postpartum. Pregnant women presented less often with symptomatic pulmonary embolism (11%) than non-pregnant women (39%). VTE developed during the first trimester in 29 (40%) pregnant patients; in the second in 13; in the third in 30. Thrombophilia tests were more often positive in women who had VTE during the first trimester (odds ratio [OR]: 4.4; 95% CI: 0.9-2.4; p=0.037). Most patients in all three groups were initially treated with low-molecular-weight heparin (LMWH). As for long-term therapy, 75% of pregnant women received LMWH until delivery. There were no maternal deaths, and no pregnant patient had recurrence or bled before delivery. However, after delivery one patient (1.4%) developed recurrent thrombosis, four (5.6%) had major bleeding. In conclusion, VTE developed during the first trimester in 40% of the pregnant women, thus suggesting that thromboprophylaxis, when indicated during pregnancy, should start in the first trimester. No patient showed recurrence or bled before delivery, but after delivery the risk of bleeding exceeded the risk of recurrences. |
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AbstractList | Venous thromboembolism (VTE) occurs infrequently during pregnancy, and issues concerning its natural history, prevention and therapy remain unresolved. RIETE is an ongoing registry of consecutive patients with objectively confirmed, symptomatic acute VTE. In this analysis, we compared the clinical characteristics and outcome for all enrolled pregnant and postpartum women with acute VTE, and all non-pregnant women in the same age range. Up to May 2005, 11,630 patients were enrolled in RIETE, of whom 848 (7.3%) were women aged <47 years. Of them, 72 (8.5%) were pregnant, 64 (7.5%) postpartum. Pregnant women presented less often with symptomatic pulmonary embolism (11%) than non-pregnant women (39%). VTE developed during the first trimester in 29 (40%) pregnant patients; in the second in 13; in the third in 30. Thrombophilia tests were more often positive in women who had VTE during the first trimester (odds ratio [OR]: 4.4; 95% CI: 0.9-2.4; p=0.037). Most patients in all three groups were initially treated with low-molecular-weight heparin (LMWH). As for long-term therapy, 75% of pregnant women received LMWH until delivery. There were no maternal deaths, and no pregnant patient had recurrence or bled before delivery. However, after delivery one patient (1.4%) developed recurrent thrombosis, four (5.6%) had major bleeding. In conclusion, VTE developed during the first trimester in 40% of the pregnant women, thus suggesting that thromboprophylaxis, when indicated during pregnancy, should start in the first trimester. No patient showed recurrence or bled before delivery, but after delivery the risk of bleeding exceeded the risk of recurrences. |
Author | Gutierrez, Reyes Lopez, Luciano Criado, Juan Trujillo-Santos, Javier Monreal, Manuel Blanco-Molina, Angeles Lecumberri, Ramón |
Author_xml | – sequence: 1 givenname: Angeles surname: Blanco-Molina fullname: Blanco-Molina, Angeles organization: Servicio de Medicina Interna, Hospital Universitario Germans Trias i Pujol, 08916 Badalona (Barcelona), Spain – sequence: 2 givenname: Javier surname: Trujillo-Santos fullname: Trujillo-Santos, Javier – sequence: 3 givenname: Juan surname: Criado fullname: Criado, Juan – sequence: 4 givenname: Luciano surname: Lopez fullname: Lopez, Luciano – sequence: 5 givenname: Ramón surname: Lecumberri fullname: Lecumberri, Ramón – sequence: 6 givenname: Reyes surname: Gutierrez fullname: Gutierrez, Reyes – sequence: 7 givenname: Manuel surname: Monreal fullname: Monreal, Manuel |
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SubjectTerms | Adult Anticoagulants - therapeutic use Female Follow-Up Studies Heparin, Low-Molecular-Weight - therapeutic use Humans Incidence Middle Aged Odds Ratio Postpartum Period Pregnancy Pregnancy Complications, Cardiovascular - diagnosis Pregnancy Complications, Cardiovascular - drug therapy Pregnancy Complications, Cardiovascular - epidemiology Pregnancy Complications, Cardiovascular - etiology Puerperal Disorders - diagnosis Puerperal Disorders - drug therapy Puerperal Disorders - epidemiology Puerperal Disorders - etiology Pulmonary Embolism - diagnosis Pulmonary Embolism - drug therapy Pulmonary Embolism - epidemiology Pulmonary Embolism - etiology Registries Risk Factors Secondary Prevention Spain - epidemiology Thromboembolism - diagnosis Thromboembolism - drug therapy Thromboembolism - epidemiology Thromboembolism - etiology Thrombophilia - complications Thrombophilia - genetics Treatment Outcome Venous Thrombosis - diagnosis Venous Thrombosis - drug therapy Venous Thrombosis - epidemiology Venous Thrombosis - etiology |
Title | Venous thromboembolism during pregnancy or postpartum: findings from the RIETE Registry |
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