Using Bacterial Transcriptomics to Investigate Targets of Host-Bacterial Interactions in Caenorhabditis elegans

• Published in: Scientific reports Vol. 9; no. 1; p. 5545
• Main Authors: Chan, Jason P., Wright, Justin R., Wong, Hoi Tong, Ardasheva, Anastasia, Brumbaugh, Jamey, McLimans, Christopher, Lamendella, Regina
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2019; Nature Publishing Group
• Subjects: 631/326/2565/2142; 631/326/325/1506; 631/326/41/2482; 631/326/41/2533; 631/337/2019; 64/11; Aging; Aging - physiology; Animals; Bacteria; Caenorhabditis elegans; Caenorhabditis elegans - genetics; Caenorhabditis elegans - microbiology; Caenorhabditis elegans - physiology; Caenorhabditis elegans Proteins - genetics; E coli; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Forkhead protein; Forkhead Transcription Factors - genetics; Gastrointestinal Microbiome - physiology; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Genetics; Health promotion; Humanities and Social Sciences; Insulin; Insulin-like growth factors; Lipopolysaccharides; Metabolic pathways; Metabolism; Microbiota; multidisciplinary; Mutation; Nematodes; Pathogenicity; Pathogens; Proof of Concept Study; Receptor, Insulin - genetics; Science; Science (multidisciplinary); Temperature; Worms

The interactions between a host and its resident microbes form complicated networks that can affect host physiology. Disentangling these host-microbe interactions can help us better understand mechanisms by which bacteria affect hosts, while also defining the integral commensal protection that host-...