Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3

• Published in: Journal of molecular and cellular cardiology Vol. 87; pp. 160 - 170
• Main Authors: Qin, Zhexue, Bagley, Jessamyn, Sukhova, Galina, Baur, Wendy E., Park, Ho-Jin, Beasley, Debbie, Libby, Peter, Zhang, Yali, Galper, Jonas B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2015
• Subjects: Abdominal aortic aneurysm; Angiotensin II; Angiotensin II - toxicity; Animals; Aortic Aneurysm, Abdominal - chemically induced; Aortic Aneurysm, Abdominal - genetics; Aortic Aneurysm, Abdominal - pathology; Apolipoproteins E - genetics; Cardiovascular; Disease Models, Animal; Gene Expression Regulation; Humans; Macrophages - metabolism; Macrophages - pathology; Male; Mice; Mice, Knockout; Signal Transduction; STAT3; STAT3 Transcription Factor - biosynthesis; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Toll-like receptor 4; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - metabolism; Angiotensin II; Abdominal aortic aneurysm; Toll-like receptor 4; STAT3

Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65years of age. Male apolipoprotein E knockout (ApoE−/−) mice infused with angiotensin II (AngII) develop AAA. Although AngII stimulates both JAK/STAT and Toll-like receptor 4 (TLR4) signaling pathways, their inv...