Determinants of Spike infectivity, processing, and neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2

• Published in: Cell host & microbe Vol. 30; no. 9; pp. 1255 - 1268.e5
• Main Authors: Pastorio, Chiara, Zech, Fabian, Noettger, Sabrina, Jung, Christoph, Jacob, Timo, Sanderson, Theo, Sparrer, Konstantin M.J., Kirchhoff, Frank
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 14.09.2022; The Authors. Published by Elsevier Inc
• Subjects: Angiotensin-Converting Enzyme 2; Antibodies, Neutralizing; Antibodies, Viral; BA.1; BA.2; BNT162 Vaccine; COVID-19; Humans; neutralization; Omicron; Pandemics; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; variant evolution; Viral Envelope Proteins; COVID-19; SARS-CoV-2; Spike protein; neutralization; variant evolution; Omicron; BA.1; BA.2

SARS-CoV-2 Omicron rapidly outcompeted other variants and currently dominates the COVID-19 pandemic. Its enhanced transmission and immune evasion are thought to be driven by numerous mutations in the Omicron Spike protein. Here, we systematically introduced BA.1 and/or BA.2 Omicron Spike mutations i...