The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin
Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number o...
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| Published in | Foods Vol. 9; no. 3; p. 374 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
23.03.2020
MDPI |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2304-8158 2304-8158 |
| DOI | 10.3390/foods9030374 |
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| Abstract | Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin. |
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| AbstractList | Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin. Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium , Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin. Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and , and parasites. Additionally, it has shown beneficial effects against Alzheimer's disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin. Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer's disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin.Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer's disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin. |
| Author | Mulla, Zohair S. Taha, Ayman E. Ikram, Muhammad Beshbishy, Amany Magdy Elewa, Yaser Hosny Ali Algammal, Abdelazeem M. Batiha, Gaber El-Saber El-Hack, Mohamed E. Abd |
| AuthorAffiliation | 8 Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt; y-elewa@vetmed.hokudai.ac.jp 2 Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt 9 Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan 1 National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro 080-8555, Japan; amanimagdi2008@gmail.com 3 Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan; ikrambiochem2014@gmail.com 4 Department of Public Health, College of Veterinary Medicine, King Faisal University, Hofuf 31982, Saudi Arabia; drzomu@gmail.com 5 Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt; dr.mohamed.e.abdalhaq@gmail.com 6 Department of Animal Husbandry and Animal W |
| AuthorAffiliation_xml | – name: 1 National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro 080-8555, Japan; amanimagdi2008@gmail.com – name: 3 Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan; ikrambiochem2014@gmail.com – name: 5 Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt; dr.mohamed.e.abdalhaq@gmail.com – name: 4 Department of Public Health, College of Veterinary Medicine, King Faisal University, Hofuf 31982, Saudi Arabia; drzomu@gmail.com – name: 9 Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan – name: 2 Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt – name: 7 Department of Bacteriology, Immunology and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt; abdelazeem.algammal@vet.suez.edu.eg or – name: 8 Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt; y-elewa@vetmed.hokudai.ac.jp – name: 6 Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Edfina 22758, Egypt; Ayman.Taha@alexu.edu.eg |
| Author_xml | – sequence: 1 givenname: Gaber El-Saber orcidid: 0000-0002-7817-425X surname: Batiha fullname: Batiha, Gaber El-Saber – sequence: 2 givenname: Amany Magdy surname: Beshbishy fullname: Beshbishy, Amany Magdy – sequence: 3 givenname: Muhammad surname: Ikram fullname: Ikram, Muhammad – sequence: 4 givenname: Zohair S. surname: Mulla fullname: Mulla, Zohair S. – sequence: 5 givenname: Mohamed E. Abd orcidid: 0000-0002-2831-8534 surname: El-Hack fullname: El-Hack, Mohamed E. Abd – sequence: 6 givenname: Ayman E. orcidid: 0000-0002-0429-2587 surname: Taha fullname: Taha, Ayman E. – sequence: 7 givenname: Abdelazeem M. orcidid: 0000-0001-5580-1559 surname: Algammal fullname: Algammal, Abdelazeem M. – sequence: 8 givenname: Yaser Hosny Ali surname: Elewa fullname: Elewa, Yaser Hosny Ali |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32210182$$D View this record in MEDLINE/PubMed |
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| Snippet | Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made... |
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| SubjectTerms | Acetylcholinesterase Alzheimer's disease Antioxidants Apoptosis Apples Arthritis Babesia Bark Bioavailability brain cabbage Cancer Carcinogens Cardiovascular diseases cauliflower Cauliflowers Cytotoxicity Diabetes Enzymes eyes Flavonoids Food science Fruits Fungicides heart Herbal medicine herbal remedies Inflammatory diseases Intestine Kinases Lipid peroxidation Lipids liver medicinal properties Microorganisms Natural products Neurodegenerative diseases Nuts Ostomy Oxidative stress Parasites Pharmacokinetics pharmacological activities Pharmacology Plants (botany) Plasmodium Quercetin Respiratory system Review Spleen Tea Theileria Wine wines |
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| Title | The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32210182 https://www.proquest.com/docview/2383831752 https://www.proquest.com/docview/2383517339 https://www.proquest.com/docview/2986100480 https://pubmed.ncbi.nlm.nih.gov/PMC7143931 https://doaj.org/article/48e1f6efe54045c1a0062650bd0af3ce |
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