DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages

• Published in: Scientific reports Vol. 8; no. 1; pp. 5723 - 14
• Main Authors: Herta, Toni, Bhattacharyya, Aritra, Bollensdorf, Christian, Kabus, Christin, García, Pedro, Suttorp, Norbert, Hippenstiel, Stefan, Zahlten, Janine
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.04.2018; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/21; 13/89; 38/22; 45/77; 631/80/304; 692/699/255/1318; 82/80; Autolysis; Deoxyribonucleic acid; DNA; Humanities and Social Sciences; Immune response; Inflammation; Interferon; Interleukin 10; KLF4 protein; Krueppel-like factor; Macrophages; multidisciplinary; MyD88 protein; Myeloid cells; Phenotypes; Science; Science (multidisciplinary); Streptococcus infections; Streptococcus pneumoniae; Supplements; TLR9 protein; Toll-like receptors

The recruitment of myeloid cells to the lung is of utmost importance for the elimination of invading pathogens. We investigated the Streptococcus pneumoniae -dependent induction mechanism of KLF4 in macrophages as a potential regulator of the macrophage immune response. We demonstrated that only via...