Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair

• Published in: Scientific reports Vol. 9; no. 1; pp. 10674 - 15
• Main Authors: Výborný, Karel, Vallová, Jana, Kočí, Zuzana, Kekulová, Kristýna, Jiráková, Klára, Jendelová, Pavla, Hodan, Jiří, Kubinová, Šárka
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.07.2019; Nature Publishing Group
• Subjects: 13/107; 14/34; 631/378/1687; 631/532/2074; Axon sprouting; Biocompatibility; Biodegradation; Carbodiimides - administration & dosage; Cell differentiation; Cell growth; Cell proliferation; Cell Proliferation - physiology; Cortex; Extracellular matrix; Extracellular Matrix - chemistry; Gelation; Genipin; Humanities and Social Sciences; Humans; Hydrogels; Hydrogels - chemistry; Inflammation; Iridoids; Mechanical properties; Mesenchymal Stem Cells - cytology; Mesenchyme; multidisciplinary; Nerve Regeneration - physiology; Neural stem cells; Photochemicals; Science; Science (multidisciplinary); Stem cells; Tissue Engineering; Tissue Scaffolds - chemistry; Tissues; Umbilical cord; Umbilical Cord - cytology

Extracellular matrix (ECM) hydrogels, produced by tissue decellularization are natural injectable materials suitable for neural tissue repair. However, the rapid biodegradation of these materials may disrupt neural tissue reconstruction in vivo . The aim of this study was to improve the stability of...