Ski proto-oncogene regulates body composition and suppresses lipogenesis

• Published in: International Journal of Obesity Vol. 34; no. 3; pp. 524 - 536
• Main Authors: Leong, G.M, Kee, A.J, Millard, S.M, Martel, N, Eriksson, N, Turner, N, Cooney, G.J, Hardeman, E.C, Muscat, G.E.O
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2010; Nature Publishing Group
• Subjects: Adipose tissue; animal models; Animals; Biological and medical sciences; Body composition; Body Composition - genetics; Body Composition - physiology; Body fat; cell differentiation; DNA-Binding Proteins - genetics; DNA-Binding Proteins - physiology; Enzymatic activity; enzyme activity; Epidemiology; Fatty acids; Fatty Acids - metabolism; Gene expression; Gene Silencing; genes; Genetic aspects; Growth - physiology; growth and development; Health Promotion and Disease Prevention; Insulin-like growth factors; Internal Medicine; Kinases; lean body mass; Lipid metabolism; lipid peroxidation; lipogenesis; Lipogenesis - genetics; lipogenic gene expression; Medical research; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Metabolism; Mice; Mice, Transgenic; Muscle, Skeletal - physiology; Musculoskeletal system; myocytes; Myogenesis; myogenic gene expression; Myostatin - metabolism; Obesity; Oncogenes; original-article; Oxidation; palmitic acid; phenotype; Physiological aspects; Proteins; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - physiology; proto-oncogenes; Public Health; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal transduction; skeletal muscle; Sterol Regulatory Element Binding Protein 1 - metabolism; Thinness - genetics; Thinness - metabolism; Transcription factors; Australia; Queensland Australia; New South Wales Australia; Ski; nuclear receptors; SREBP1c; metabolism; adipogenesis; skeletal muscle; Obesity; Nuclear receptor; Nutrition; Skiing; Nutrition disorder; Metabolic diseases; Striated muscle; Metabolism; Body composition; Sport; Regulation(control); C-Onc gene; Lipogenesis; Nutritional status; Protooncogene

Objective: The Ski gene regulates skeletal muscle differentiation in vitro and and in vivo. In the c-Ski overexpression mouse model there occurs marked skeletal muscle hypertrophy with decreased adipose tissue mass. In this study, we have investigated the underlying molecular mechanisms responsible...