Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling

• Published in: eLife Vol. 12
• Main Authors: Guimarães, Rafaela M, Aníbal-Silva, Conceição E, Davoli-Ferreira, Marcela, Gomes, Francisco Isaac F, Mendes, Atlante, Cavallini, Maria C M, Fonseca, Miriam M, Damasceno, Samara, Andrade, Larissa P, Colonna, Marco, Rivat, Cyril, Cunha, Fernando Q, Alves-Filho, José C, Cunha, Thiago M
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 31.05.2023; eLife Sciences Publications Ltd; eLife Sciences Publications, Ltd
• Subjects: Animals; CCR2; Cell body; Cell Proliferation; CX3CR1; CX3CR1 protein; Cytokines; Experiments; Flow cytometry; Ganglia, Sensory; Ganglia, Spinal; Hyperalgesia; Immunology and Inflammation; Infections; Infiltration; Inflammation; Interleukin 1; Macrophages; Mice; Monocytes; nerve injury; Neuralgia; Neurons; Neutrophils; Peripheral blood; Peripheral Nerve Injuries - complications; Peripheral nerves; Peripheral neuropathy; Physiological aspects; Scientific equipment and supplies industry; Sensory neurons; Sensory Receptor Cells; United States; CX3CR1; monocytes; mouse; macrophages; inflammation; nerve injury; cytokines; immunology; CCR2

Resident macrophages are distributed across all tissues and are highly heterogeneous due to adaptation to different tissue-specific environments. The resident macrophages of the sensory ganglia (sensory neuron-associated macrophages, sNAMs) are in close contact with the cell body of primary sensory...