Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework
Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stres...
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Published in | Toxicology and applied pharmacology Vol. 222; no. 1; pp. 122 - 128 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
San Diego, CA
Elsevier Inc
01.07.2007
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines. |
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Bibliography: | http://hdl.handle.net/10113/25517 http://dx.doi.org/10.1016/j.taap.2007.02.015 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0041-008X 1096-0333 1096-0333 |
DOI: | 10.1016/j.taap.2007.02.015 |