MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes

• Published in: Journal of molecular and cellular cardiology Vol. 148; pp. 46 - 49
• Main Authors: Lu, Dongchao, Chatterjee, Shambhabi, Xiao, Ke, Riedel, Isabelle, Wang, Yibin, Foo, Roger, Bär, Christian, Thum, Thomas
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2020; The Authors. Published by Elsevier Ltd
• Subjects: ACE2; Angiotensin-Converting Enzyme 2 - genetics; Animals; Cardiomyocytes; Cells, Cultured; Computer Simulation; COVID-19; COVID-19 - genetics; COVID-19 - virology; Fibroblasts - metabolism; Human Umbilical Vein Endothelial Cells; Humans; Induced Pluripotent Stem Cells - cytology; Mice; MicroRNAs - genetics; miRNAs; Myocardium - metabolism; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - virology; Rats; Real-Time Polymerase Chain Reaction; SARS-CoV-2; Short Communication; COVID-19; ACE2; Cardiomyocytes; miRNAs

The World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a public health emergency of international concern as more than 15 million cases were reported by 24th July 2020. Angiotensin-converting enzyme 2 (ACE2) is a COVID-19 entry receptor regulating host cell infection. A...