Does the endometrial cavity have a molecular microbial signature?
Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. He...
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| Published in | Scientific reports Vol. 9; no. 1; pp. 9905 - 17 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
09.07.2019
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Recent molecular studies concluded that the endometrium has a resident microbiota dominated by
Lactobacillus
spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. Herein, we investigated the molecular microbial profiles of mid-endometrial samples obtained through hysterectomy and compared them with those of the cervix, vagina, rectum, oral cavity, and controls for background DNA contamination. Microbial profiles were examined through 16S rRNA gene qPCR and sequencing. Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects. Bacterial profiles of the endometrium differed from those of the oral cavity, rectum, vagina, and background DNA controls, but not of the cervix. The bacterial profiles of the endometrium and cervix were dominated by
Acinetobacter
,
Pseudomonas
,
Cloacibacterium
, and Comamonadaceae. Both 16S rRNA gene sequencing and
Lactobacillus
species-specific (
L
.
iners
&
L crispatus
) qPCR showed that
Lactobacillus
was rare in the endometrium. In conclusion, if there is a microbiota in the middle endometrium, it is not dominated by
Lactobacillus
as was previously concluded, yet further investigation using culture and microscopy is necessary. |
|---|---|
| AbstractList | Recent molecular studies concluded that the endometrium has a resident microbiota dominated by
Lactobacillus
spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. Herein, we investigated the molecular microbial profiles of mid-endometrial samples obtained through hysterectomy and compared them with those of the cervix, vagina, rectum, oral cavity, and controls for background DNA contamination. Microbial profiles were examined through 16S rRNA gene qPCR and sequencing. Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects. Bacterial profiles of the endometrium differed from those of the oral cavity, rectum, vagina, and background DNA controls, but not of the cervix. The bacterial profiles of the endometrium and cervix were dominated by
Acinetobacter
,
Pseudomonas
,
Cloacibacterium
, and Comamonadaceae. Both 16S rRNA gene sequencing and
Lactobacillus
species-specific (
L
.
iners
&
L crispatus
) qPCR showed that
Lactobacillus
was rare in the endometrium. In conclusion, if there is a microbiota in the middle endometrium, it is not dominated by
Lactobacillus
as was previously concluded, yet further investigation using culture and microscopy is necessary. Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. Herein, we investigated the molecular microbial profiles of mid-endometrial samples obtained through hysterectomy and compared them with those of the cervix, vagina, rectum, oral cavity, and controls for background DNA contamination. Microbial profiles were examined through 16S rRNA gene qPCR and sequencing. Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects. Bacterial profiles of the endometrium differed from those of the oral cavity, rectum, vagina, and background DNA controls, but not of the cervix. The bacterial profiles of the endometrium and cervix were dominated by Acinetobacter, Pseudomonas, Cloacibacterium, and Comamonadaceae. Both 16S rRNA gene sequencing and Lactobacillus species-specific (L. iners & L crispatus) qPCR showed that Lactobacillus was rare in the endometrium. In conclusion, if there is a microbiota in the middle endometrium, it is not dominated by Lactobacillus as was previously concluded, yet further investigation using culture and microscopy is necessary.Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. Herein, we investigated the molecular microbial profiles of mid-endometrial samples obtained through hysterectomy and compared them with those of the cervix, vagina, rectum, oral cavity, and controls for background DNA contamination. Microbial profiles were examined through 16S rRNA gene qPCR and sequencing. Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects. Bacterial profiles of the endometrium differed from those of the oral cavity, rectum, vagina, and background DNA controls, but not of the cervix. The bacterial profiles of the endometrium and cervix were dominated by Acinetobacter, Pseudomonas, Cloacibacterium, and Comamonadaceae. Both 16S rRNA gene sequencing and Lactobacillus species-specific (L. iners & L crispatus) qPCR showed that Lactobacillus was rare in the endometrium. In conclusion, if there is a microbiota in the middle endometrium, it is not dominated by Lactobacillus as was previously concluded, yet further investigation using culture and microscopy is necessary. Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the vagina. These findings were largely derived from endometrial samples obtained through a transcervical catheter and thus prone to contamination. Herein, we investigated the molecular microbial profiles of mid-endometrial samples obtained through hysterectomy and compared them with those of the cervix, vagina, rectum, oral cavity, and controls for background DNA contamination. Microbial profiles were examined through 16S rRNA gene qPCR and sequencing. Universal bacterial qPCR of total 16S rDNA revealed a bacterial load exceeding that of background DNA controls in the endometrium of 60% (15/25) of the study subjects. Bacterial profiles of the endometrium differed from those of the oral cavity, rectum, vagina, and background DNA controls, but not of the cervix. The bacterial profiles of the endometrium and cervix were dominated by Acinetobacter, Pseudomonas, Cloacibacterium, and Comamonadaceae. Both 16S rRNA gene sequencing and Lactobacillus species-specific (L. iners & L crispatus) qPCR showed that Lactobacillus was rare in the endometrium. In conclusion, if there is a microbiota in the middle endometrium, it is not dominated by Lactobacillus as was previously concluded, yet further investigation using culture and microscopy is necessary. |
| ArticleNumber | 9905 |
| Author | Winters, Andrew D. Gervasi, Maria Teresa Tran, Maria Rosa Garcia-Flores, Valeria Jung, Eunjung Pacora, Percy Hsu, Chaur-Dong Gomez-Lopez, Nardhy Hassan, Sonia S. Theis, Kevin R. Romero, Roberto |
| Author_xml | – sequence: 1 givenname: Andrew D. surname: Winters fullname: Winters, Andrew D. organization: Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Perinatal Research Initiative in Maternal, Perinatal and Child Health, Wayne State University School of Medicine, Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI – sequence: 2 givenname: Roberto surname: Romero fullname: Romero, Roberto email: prbchiefstaff@med.wayne.edu organization: Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, University of Michigan, Department of Epidemiology and Biostatistics, Michigan State University, Center for Molecular Medicine and Genetics, Wayne State University, Detroit Medical Center – sequence: 3 givenname: Maria Teresa surname: Gervasi fullname: Gervasi, Maria Teresa organization: Department of Women’s and Children’s Health, University Hospital of Padua – sequence: 4 givenname: Nardhy surname: Gomez-Lopez fullname: Gomez-Lopez, Nardhy organization: Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Perinatal Research Initiative in Maternal, Perinatal and Child Health, Wayne State University School of Medicine, Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine – sequence: 5 givenname: Maria Rosa surname: Tran fullname: Tran, Maria Rosa organization: Department of Women’s and Children’s Health, University Hospital of Padua – sequence: 6 givenname: Valeria surname: Garcia-Flores fullname: Garcia-Flores, Valeria organization: Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine – sequence: 7 givenname: Percy surname: Pacora fullname: Pacora, Percy organization: Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine – sequence: 8 givenname: Eunjung surname: Jung fullname: Jung, Eunjung organization: Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine – sequence: 9 givenname: Sonia S. surname: Hassan fullname: Hassan, Sonia S. organization: Perinatal Research Initiative in Maternal, Perinatal and Child Health, Wayne State University School of Medicine, Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Department of Physiology, Wayne State University School of Medicine – sequence: 10 givenname: Chaur-Dong surname: Hsu fullname: Hsu, Chaur-Dong organization: Perinatal Research Initiative in Maternal, Perinatal and Child Health, Wayne State University School of Medicine, Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Department of Physiology, Wayne State University School of Medicine – sequence: 11 givenname: Kevin R. surname: Theis fullname: Theis, Kevin R. email: ktheis@med.wayne.edu organization: Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Perinatal Research Initiative in Maternal, Perinatal and Child Health, Wayne State University School of Medicine, Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, and Detroit, MI |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31289304$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | The Author(s) 2019 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Snippet | Recent molecular studies concluded that the endometrium has a resident microbiota dominated by
Lactobacillus
spp. and is therefore similar to that of the... Recent molecular studies concluded that the endometrium has a resident microbiota dominated by Lactobacillus spp. and is therefore similar to that of the... |
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| Title | Does the endometrial cavity have a molecular microbial signature? |
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