Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease

• Published in: Annals of hepatology Vol. 27; no. 4; p. 100709
• Main Authors: Cook, Joshua J., Wei, Madeline, Segovia, Benny, Cosio-Lima, Ludmila, Simpson, Jeffrey, Taylor, Scott, Koh, Yunsuk, Kim, Sangho, Lee, Youngil
• Format: Journal Article
• Language: English
• Published: Mexico Elsevier España, S.L.U 01.07.2022; Elsevier
• Subjects: Endurance exercise; Gastroenterology and Hepatology; Mitochondria; Non-alcoholic fatty liver disease; Oxidative stress; Senescence; Oxidative stress; Senescence; NAFLD; ACSS2; ATGL; LC3-II; PARP; ABHD5; p53; Mitochondria; CuZnSOD; PI3K; CPT-1A; p16; LAMP2; mTOR; PCK1; ATG7; GSK; HSL; GLUT2; G6PD; G6PC; NADPHOx2; DGAT1; ACSL1; Endurance exercise; TFEB; IRβ; AKT; PGD; IL-1β; p21; FABP1; ACLY; EXE; TNF-α; MnSOD; CASPASE3; BCL2; FAT; AMPK; Non-alcoholic fatty liver disease; GAPDH; glucose-6-phosphate dehydrogenase; glucose transporter 2; transcription factor EB; fatty acid translocase; hormone sensitive lipase; adipose triglyceride lipase; manganese superoxide dismutase; phosphatidylinositol 3 kinase; copper zinc superoxide dismutase; Acyl-CoA synthetase long chain family member 1; NADPH oxidase 2; non-acholic fatty liver disease; ATP Citrate Lyase; microtubule-associated protein B-light chain 3 II; autophagy protein 7; 6-phosphogluconate dehydrogenase; interleukin-1 β; cyclin-dependent kinase inhibitor 2A; diacylglycerol O-acyltransferase 1; fatty acid binding protein 1; B-Cell Leukemia/Lymphoma 2; mammalian target of rapamycin; Acyl-CoA Synthetase Short Chain Family Member 2; glyceraldehyde-3-phosphate dehydrogenase; tumor suppressor protein 53; protein kinase B; adenosine mono phosphate-activated protein kinase; cyclin-dependent kinase inhibitor 1; alpha-beta hydrolase domain-containing 5; insulin receptor β; phosphoenolpyruvate carboxykinase1; lysosome-associated membrane protein 2; carnitine palmitoyl transferase 1A; cysteine-dependent aspartate-directed protease 3; tumor necrosis factor- α; glycogen synthase kinase; poly ADP ribose polymerase; glucose-6-phosphatase

Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in the United States. Metabolic distress (obese diabetes) is the main causative element of NAFLD. While there is no cure for NAFLD, endurance exercise (EEx) has emerged as a therapeutic strategy against NAFLD. However, mech...