Lymph node resection induces the activation of tumor cells in the lungs

• Published in: Cancer science Vol. 110; no. 2; pp. 509 - 518
• Main Authors: Sukhbaatar, Ariunbuyan, Mori, Shiro, Saiki, Yuriko, Takahashi, Tetsu, Horii, Akira, Kodama, Tetsuya
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2019; John Wiley and Sons Inc
• Subjects: activation; Animals; Biopsy; Biopsy - adverse effects; Breast cancer; Cancer therapies; Cell activation; Cell cycle; Disease Models, Animal; Dissection; Female; Head & neck cancer; Inoculation; Intervention; Intravenous administration; Lung - pathology; Lung - surgery; lung metastasis; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lungs; Lymph Node Excision - methods; lymph node resection; Lymph nodes; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis - pathology; Lymphatic system; Male; Metastases; Metastasis; Mice; mouse model; Neoplasm Staging - methods; Original; Patients; Studies; Surgery; Tumor cells; Japan; lymph node resection; lung metastasis; tumor cells; mouse model; activation

Lymph node (LN) dissection is a crucial procedure for cancer staging, diagnosis and treatment, and for predicting patient survival. Activation of lung metastatic lesions after LN dissection has been described for head and neck cancer and breast cancer. Preclinical studies have reported that dissecti...