Damage to the cingulum contributes to alzheimer's disease pathophysiology by deafferentation mechanism

• Published in: Human brain mapping Vol. 33; no. 6; pp. 1295 - 1308
• Main Authors: Bozzali, Marco, Giulietti, Giovanni, Basile, Barbara, Serra, Laura, Spanò, Barbara, Perri, Roberta, Giubilei, Franco, Marra, Camillo, Caltagirone, Carlo, Cercignani, Mara
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.06.2012; Wiley-Liss; John Wiley & Sons, Inc
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Atrophy - pathology; Atrophy - physiopathology; Biological and medical sciences; cingulum; Cognitive Dysfunction - pathology; Cognitive Dysfunction - physiopathology; deafferentation; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Diffusion Tensor Imaging; Disease Progression; DT-MRI; Female; Gyrus Cinguli - pathology; Gyrus Cinguli - physiopathology; Humans; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging; Male; MCI; Medical sciences; Middle Aged; Nerve Fibers, Myelinated - pathology; Nerve Fibers, Unmyelinated - pathology; Nervous system; Neurology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; tractography; VBM; VBM; Nervous system diseases; AD; Pathophysiology; Radiodiagnosis; Alzheimer disease; Tractography; Nuclear magnetic resonance imaging; Cerebral disorder; MCI; cingulum; Central nervous system disease; DT-MRI; Degenerative disease; Deafferentation

This study investigates the differential contribution of gray matter (GM) atrophy and deafferentation through white matter (WM) damage in the clinical progression of Alzheimer's disease (AD). Thirty‐one patients with probable AD, 23 with amnestic mild cognitive impairment (a‐MCI), and 14 health...