TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

• Published in: Journal of neuropathology and experimental neurology Vol. 69; no. 9; pp. 918 - 929
• Main Authors: McKee, Ann C., Gavett, Brandon E., Stern, Robert A., Nowinski, Christopher J., Cantu, Robert C., Kowall, Neil W., Perl, Daniel P., Hedley-Whyte, E. Tessa, Price, Bruce, Sullivan, Chris, Morin, Peter, Lee, Hyo-Soon, Kubilus, Caroline A., Daneshvar, Daniel H., Wulff, Megan, Budson, Andrew E.
• Format: Journal Article
• Language: English
• Published: England American Association of Neuropathologists, Inc 01.09.2010; Oxford University Press
• Subjects: Adult; Aged; Aged, 80 and over; Athletes; Athletic Injuries - complications; Athletic Injuries - pathology; Brain - anatomy & histology; Brain - metabolism; Brain - pathology; Brain Injury, Chronic - complications; Brain Injury, Chronic - pathology; Brain Injury, Chronic - physiopathology; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Humans; Middle Aged; Motor Neuron Disease - etiology; Motor Neuron Disease - pathology; Motor Neuron Disease - physiopathology; TDP-43 Proteinopathies - etiology; TDP-43 Proteinopathies - pathology; TDP-43 Proteinopathies - physiopathology

Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive head injury is also associated with the development of chronic traumatic encephalopathy (CTE), a tauopathy characterized by neurofibrillary tangles throughou...