Evidence of protection against clinical and chronic hepatitis B infection 20 years after infant vaccination in a high endemicity region

• Published in: Journal of viral hepatitis Vol. 18; no. 5; pp. 369 - 375
• Main Authors: Poovorawan, Y., Chongsrisawat, V., Theamboonlers, A., Leroux-Roels, G., Kuriyakose, S., Leyssen, M., Jacquet, J.-M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.2011
• Subjects: Adolescent; Carrier State - epidemiology; Carrier State - immunology; Carrier State - prevention & control; Child; Child, Preschool; DNA, Viral - blood; efficacy; Endemic Diseases - prevention & control; Female; hepatitis B; Hepatitis B Antibodies - blood; Hepatitis B e Antigens - blood; Hepatitis B e Antigens - immunology; Hepatitis B Surface Antigens - blood; Hepatitis B Surface Antigens - immunology; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; Hepatitis B virus - genetics; Hepatitis B virus - immunology; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - epidemiology; Hepatitis B, Chronic - immunology; Hepatitis B, Chronic - prevention & control; Hepatitis B, Chronic - virology; Humans; Immunization, Secondary; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Longitudinal Studies; Male; Original; Pregnancy; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; Thailand - epidemiology; vaccine; Young Adult; Thailand

Vaccination against hepatitis B virus (HBV) immediately after birth prevents neonatal infection by vertical transmission from HBV carrier mothers. There is an ongoing debate whether infant vaccination is sufficient to protect against infection when exposed to HBV later in life. We studied 222 Thai i...